KEGG   DRUG: Dihydrocodeine phosphate, dl-methylephedrine hydrochloride and Chlorpheniramine maleate
Entry
D04313            Mixture   Drug                                   
Name
Dihydrocodeine phosphate, dl-methylephedrine hydrochloride and Chlorpheniramine maleate;
Huscode (TN)
Component
Dihydrocodeine phosphate [DR:D01481], dl-Methylephedrine hydrochloride [DR:D02109], Chlorpheniramine maleate [DR:D00665]
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
  DG03189  UGT2B4 substrate
  DG03190  UGT2B7 substrate
Remark
Therapeutic category: 2229
ATC code: R06AB54
Product: D04313<JP>
Efficacy
Antitussive
Comment
Dihydrocodeine phosphate is metabolized by UGT2B7, UGT2B4 with some contribution from CYP3A4 and CYP2D6.
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B4 [HSA:7363]; CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB54 Chlorphenamine, combinations
      D04313  Dihydrocodeine phosphate, dl-methylephedrine hydrochloride and Chlorpheniramine maleate <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   222  Antitussives
    2229  Others
     D04313  Dihydrocodeine phosphate, dl-methylephedrine hydrochloride and Chlorpheniramine maleate
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D04313  Dihydrocodeine phosphate, dl-methylephedrine hydrochloride and Chlorpheniramine maleate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D04313  Dihydrocodeine phosphate, dl-methylephedrine hydrochloride and Chlorpheniramine maleate
  DG02924  UGT substrate
   DG03189  UGT2B4 substrate
    D04313  Dihydrocodeine phosphate, dl-methylephedrine hydrochloride and Chlorpheniramine maleate
   DG03190  UGT2B7 substrate
    D04313  Dihydrocodeine phosphate, dl-methylephedrine hydrochloride and Chlorpheniramine maleate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04313
Other DBs
PubChem: 17398050
LinkDB

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