KEGG   DRUG: Ethinylestradiol and levonorgestrel
Entry
D04482            Mixture   Drug                                   
Name
Ethinylestradiol and levonorgestrel;
Ange (TN);
Levora (TN);
Lo/ovral (TN);
Seasonique (TN);
Triphasil-21 (TN);
Trivora (TN)
Product
BALCOLTRA (Avion Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL (Acella Pharmaceuticals), TWIRLA (Agile Therapeutics), TYBLUME (Exeltis USA)
  Generic
AFIRMELLE (Aurobindo Pharma Limited), ALTAVERA (Bryant Ranch Prepack), ALTAVERA (Xiromed), AMETHYST (Teva Pharmaceuticals), ASHLYNA (A-S Medication Solutions), ASHLYNA (Glenmark Pharmaceuticals), AUBRA EQ (Afaxys Pharma), AVIANE (Proficient Rx LP), AVIANE (Teva Pharmaceuticals USA), AYUNA (Aurobindo Pharma Limited), CAMRESE (Teva Pharmaceuticals USA), CAMRESE LO (Teva Pharmaceuticals USA), CHATEAL EQ (Afaxys Pharma), CHATEAL EQ (Redpharm Drug), DAYSEE (Lupin Pharmaceuticals), DOLISHALE (Ingenus Pharmaceuticals), ENPRESSE (Teva Pharmaceuticals USA), FALMINA (Northstar Rx LLC), ICLEVIA (Aurobindo Pharma Limited), INTROVALE (Xiromed LLC), INTROVALE (Xiromed), JAIMIESS (Bryant Ranch Prepack), JAIMIESS (Xiromed LLC), JAIMIESS (Xiromed), JOLESSA (Teva Pharmaceuticals USA), JOYEAUX (Xiromed), KURVELO (A-S Medication Solutions), KURVELO (Lupin Pharmaceuticals), LESSINA (Teva Pharmaceuticals USA), LEVONEST (A-S Medication Solutions), LEVONEST (Northstar Rx LLC), LEVONORGESTREL AND ETHINYL ESTRADIOL (Amneal Pharmaceuticals NY LLC), LEVONORGESTREL AND ETHINYL ESTRADIOL (Glenmark Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL (Glenmark Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL (Lupin Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL (Lupin Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL (Lupin Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL (Mylan Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL (Mylan Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL (Mylan Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL (Naari Pte Limited), LEVONORGESTREL AND ETHINYL ESTRADIOL (Naari Pte Limited), LEVONORGESTREL AND ETHINYL ESTRADIOL AND ETHINYL ESTRADIOL (Lupin Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL AND ETHINYL ESTRADIOL (Mylan Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL AND ETHINYL ESTRADIOL (Mylan Pharmaceuticals), LEVONORGESTREL AND ETHINYL ESTRADIOL AND ETHINYL ESTRADIOL (Mylan Pharmaceuticals), LEVONORGETSREL AND ETHINYL ESTRADIOL (Camber Pharmaceuticals), LEVORA (Dr. Reddy's Laboratories), LEVORA (Mayne Pharma), LOJAIMIESS (Xiromed LLC), LUTERA (Dr. Reddy's Laboratories), LUTERA (Mayne Pharma), MARLISSA (Glenmark Pharmaceuticals), MINZOYA (Lupin Pharmaceuticals), PORTIA (Teva Pharmaceuticals USA), RIVELSA (Teva Pharmaceuticals USA), ROSYRAH (Xiromed), SETLAKIN (Northstar Rx LLC), SIMPESSE (Aurobindo Pharma Limited), SRONYX (Dr. Reddy's Labratories), SRONYX (Mayne Pharma), TRIVORA (Mayne Pharma), VIENVA (Xiromed), VIENVA TM (A-S Medication Solutions), VIENVA TM (Bryant Ranch Prepack)
Component
Ethinylestradiol [DR:D00554], Levonorgestrel [DR:D00950]
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2482 2549
ATC code: G03AA07 G03AB03 G03FA11 G03FB09
Product: D04482<JP/US>
Efficacy
Contraceptive, Menstruation disorder agent
Comment
Combinatin of estrogen and progestin
Ethinylestradiol is primarily metabolized by CYP3A4.
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AA Progestogens and estrogens, fixed combinations
     G03AA07 Levonorgestrel and ethinylestradiol
      D04482  Ethinylestradiol and levonorgestrel <JP/US>
    G03AB Progestogens and estrogens, sequential preparations
     G03AB03 Levonorgestrel and ethinylestradiol
      D04482  Ethinylestradiol and levonorgestrel <JP/US>
   G03F PROGESTOGENS AND ESTROGENS IN COMBINATION
    G03FA Progestogens and estrogens, fixed combinations
     G03FA11 Levonorgestrel and estrogen
      D04482  Ethinylestradiol and levonorgestrel <JP/US>
    G03FB Progestogens and estrogens, sequential preparations
     G03FB09 Levonorgestrel and estrogen
      D04482  Ethinylestradiol and levonorgestrel <JP/US>
USP drug classification [BR:br08302]
 Contraceptives
  Oral Contraceptives Combinations
   Ethinyl Estradiol/ Levonorgestrel
    D04482  Ethinylestradiol and levonorgestrel
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   248  Mixed hormone preparations
    2482  Estrogens and progestins
     D04482  Ethinylestradiol and levonorgestrel
  25  Urogenital and anal organ agents
   254  Contraceptives
    2549  Others
     D04482  Ethinylestradiol and levonorgestrel
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D04482  Ethinylestradiol and levonorgestrel
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04482
Other DBs
PubChem: 17398125
LinkDB

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