KEGG   DRUG: Maribavir
Entry
D04859                      Drug                                   
Name
Maribavir (JAN/USAN/INN);
Camvia (TN);
Livtencity (TN)
Product
LIVTENCITY (Takeda Pharmaceuticals America)
Formula
C15H19Cl2N3O4
Exact mass
375.0753
Mol weight
376.23
Structure
Class
Antiviral
 DG01937  Anti-cytomegalovirus agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 6250
ATC code: J05AX10
Product: D04859<JP/US>
Efficacy
Antiviral, Protein kinase inhibitor
  Disease
Cytomegalovirus infection [DS:H00368]
Comment
L-ribofuranosyl nucleoside
Treatment of cytomegalovirus infections
Target
HCMV tegument serine/threonine protein kinase [KO:K26102]
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP1A2 [HSA:1544]
Interaction
Structure map
map07044  Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AX Other antivirals
     J05AX10 Maribavir
      D04859  Maribavir (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-cytomegalovirus (CMV) Agents
   Maribavir
    D04859  Maribavir (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D04859  Maribavir (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antiviral
  DG01937  Anti-cytomegalovirus agent
   D04859  Maribavir
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   D04859  Maribavir
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D04859  Maribavir
Drug classes [BR:br08332]
 Antiviral
  DG01937  Anti-cytomegalovirus agent
   D04859  Maribavir
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   Other inhibitor
    D04859  Maribavir (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04859
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04859
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04859
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04859
Other DBs
CAS: 176161-24-3
PubChem: 47206634
LigandBox: D04859
NIKKAJI: J1.159.817J
LinkDB
KCF data

ATOM        24
            1   C1y C    12.7400  -27.0900
            2   C1y C    11.3400  -27.0900
            3   C1y C    10.9200  -25.7600
            4   O2x O    12.0400  -24.9900
            5   C1y C    13.1600  -25.7600
            6   O1a O    13.5100  -28.2100
            7   O1a O    10.5700  -28.2100
            8   C1b C     9.7300  -25.0600
            9   O1a O     8.5400  -25.7600
            10  N4y N    14.3500  -25.0600
            11  C8y C    17.9491  -27.0906
            12  C8y C    16.7944  -27.8823
            13  C8x C    15.5441  -27.2967
            14  C8y C    15.4089  -25.8617
            15  C8y C    16.5636  -25.0700
            16  C8x C    17.8534  -25.7133
            17  C8y C    14.8383  -23.7916
            18  N5x N    16.1974  -23.7933
            19  N1b N    14.0466  -22.6369
            20  C1c C    14.6322  -21.3867
            21  C1a C    13.8800  -20.2898
            22  C1a C    15.9517  -21.4006
            23  X   Cl   16.9296  -29.3173
            24  X   Cl   19.2389  -27.7339
BOND        26
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1 #Up
            7     2   7 1 #Up
            8     3   8 1 #Down
            9     8   9 1
            10    5  10 1 #Down
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   14  10 1
            18   17  18 2
            19   15  18 1
            20   17  19 1
            21   19  20 1
            22   20  21 1
            23   20  22 1
            24   12  23 1
            25   11  24 1
            26   10  17 1

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