| Entry |
|
|---|
| Name |
Pirenzepine hydrochloride hydrate (JP18);
Gastrozepin (TN) |
|---|
| Formula |
C19H21N5O2. 2HCl. H2O
|
|---|
| Exact mass |
441.1334
|
|---|
| Mol weight |
442.34
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
Gastrointestinal agent
DG01975 Agents for peptic ulcer
|
|---|
| Remark |
| Therapeutic category: | 2329 |
| Product (DG00026): | D05276<JP> |
|
|---|
| Efficacy |
Antisecretory (gastric acid), Anti-ulcerative, Muscarinic acetylcholine receptor antagonist |
|---|
| Comment |
Tricyclic compound
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07220 | Cholinergic and anticholinergic drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BX Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
A02BX03 Pirenzepine
D05276 Pirenzepine hydrochloride hydrate (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
232 Peptic ulcer agents
2329 Others
D05276 Pirenzepine hydrochloride hydrate (JP18)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Pirenzepine
D05276 Pirenzepine hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00026 Pirenzepine
D05276 Pirenzepine hydrochloride hydrate
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG00026 Pirenzepine
D05276 Pirenzepine hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM
D05276 Pirenzepine hydrochloride hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D05276 Pirenzepine hydrochloride hydrate
Rx-to-OTC switch list in Japan [br08314.html]
D05276
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00026 Pirenzepine
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG00026 Pirenzepine
|
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| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 29
1 O0 O 36.9166 -21.1757
2 X Cl 36.5234 -18.9862
3 C5x C 29.1159 -24.0767
4 C8y C 28.2760 -22.9569
5 C8y C 28.6260 -21.6271
6 N1y N 29.8858 -21.0672
7 N1x N 30.5157 -24.0767
8 C8y C 31.1456 -21.6971
9 C8y C 31.4256 -23.0269
10 C8x C 27.5761 -20.6472
11 C8x C 26.2463 -21.0672
12 C8x C 25.8964 -22.3970
13 C8x C 26.9462 -23.3768
14 C8x C 32.7554 -23.4468
15 C8x C 33.8053 -22.5370
16 C8x C 33.5253 -21.1372
17 N5x N 32.1955 -20.7172
18 O5x O 28.4860 -25.3366
19 C5a C 29.8858 -19.6674
20 C1b C 31.0757 -18.9675
21 O5a O 28.6960 -18.9675
22 N1y N 31.0757 -17.5677
23 C1x C 32.3355 -16.8678
24 C1x C 32.3355 -15.4680
25 N1y N 31.0757 -14.7680
26 C1x C 29.8858 -15.4680
27 C1x C 29.8858 -16.8678
28 C1a C 31.0757 -13.3682
29 X Cl 36.5234 -18.9862
BOND 29
1 5 6 1
2 3 7 1
3 6 8 1
4 4 5 1
5 7 9 1
6 3 4 1
7 8 9 1
8 5 10 2
9 10 11 1
10 11 12 2
11 12 13 1
12 4 13 2
13 9 14 2
14 14 15 1
15 15 16 2
16 16 17 1
17 8 17 2
18 3 18 2
19 6 19 1
20 19 20 1
21 19 21 2
22 20 22 1
23 22 23 1
24 23 24 1
25 24 25 1
26 25 26 1
27 26 27 1
28 22 27 1
29 25 28 1
BRACKET 1 34.7900 -19.9500 34.7900 -17.7800
1 37.3100 -17.7800 37.3100 -19.9500
1 2
ORIGINAL 1 2
REPEAT 1 29
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