| Entry |
|
|---|
| Name |
Cevimeline (INN) |
|---|
| Formula |
C10H17NOS
|
|---|
| Exact mass |
199.1031
|
|---|
| Mol weight |
199.32
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG01719 Parasympathomimetic agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00993): | D00661<JP/US> |
|
|---|
| Efficacy |
Salivation accelaletor, Muscarinic acetylcholine receptor agonist |
|---|
| Comment |
Arecoline derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07A PARASYMPATHOMIMETICS
N07AX Other parasympathomimetics
N07AX03 Cevimeline
D07667 Cevimeline (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG00993 Cevimeline
D07667 Cevimeline
DG01719 Parasympathomimetic agent
DG00993 Cevimeline
D07667 Cevimeline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00993 Cevimeline
D07667 Cevimeline
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00993 Cevimeline
D07667 Cevimeline
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM3
D07667 Cevimeline (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07667
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG00993 Cevimeline
DG01719 Parasympathomimetic agent
DG00993 Cevimeline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00993 Cevimeline
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00993 Cevimeline
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 13
1 C1z C 24.2900 -17.4300
2 C1y C 24.2900 -16.0300
3 C1x C 23.0300 -18.2000
4 C1x C 23.0300 -15.2600
5 C1x C 23.4500 -16.8700
6 N1y N 21.7700 -17.4300
7 C1x C 21.7700 -16.0300
8 C1x C 22.7500 -16.3800
9 O2x O 24.2900 -18.8300
10 C1y C 25.6900 -19.3200
11 S2x S 26.5300 -18.1300
12 C1x C 25.6900 -16.9400
13 C1a C 26.1100 -20.6500
BOND 15
1 1 2 1
2 1 3 1
3 2 4 1
4 2 5 1
5 3 6 1
6 4 7 1
7 5 8 1
8 6 7 1
9 6 8 1
10 1 9 1 #Up
11 9 10 1
12 10 11 1
13 11 12 1
14 1 12 1
15 10 13 1 #Down
|
|---|
