KEGG   DRUG: Melphalan hydrochloride
Entry
D08173                      Drug                                   
Name
Melphalan hydrochloride;
Alkeran (TN);
Evomela (TN)
Product
EVOMELA (Acrotech Biopharma), HEPZATO KIT (Delcath Systems)
  Generic
MELPHALAN (Fresenius Kabi USA), MELPHALAN HYDROCHLORIDE (Actavis Pharma), MELPHALAN HYDROCHLORIDE (Almaject), MELPHALAN HYDROCHLORIDE (Arthur Group LLC), MELPHALAN HYDROCHLORIDE (Athenex Pharmaceutical Division), MELPHALAN HYDROCHLORIDE (Avenacy), MELPHALAN HYDROCHLORIDE (BPI Labs LLC), MELPHALAN HYDROCHLORIDE (Camber Pharmaceuticals), MELPHALAN HYDROCHLORIDE (Dr.Reddy's Laboratories), MELPHALAN HYDROCHLORIDE (Dr.Reddy's Laboratories), MELPHALAN HYDROCHLORIDE (Dr.Reddy's Laboratories), MELPHALAN HYDROCHLORIDE (Fosun Pharma USA), MELPHALAN HYDROCHLORIDE (Gland Pharma Limited), MELPHALAN HYDROCHLORIDE (Meitheal Pharmaceuticals), MELPHALAN HYDROCHLORIDE (Meitheal Pharmaceuticals), MELPHALAN HYDROCHLORIDE (Mylan Institutional LLC), MELPHALAN HYDROCHLORIDE (Mylan Institutional LLC), MELPHALAN HYDROCHLORIDE (Qilu Pharmaceutical), MELPHALAN HYDROCHLORIDE (Sagent Pharmaceuticals)
Formula
C13H18Cl2N2O2. HCl
Exact mass
340.0512
Mol weight
341.66
Structure
Simcomp
Class
Antineoplastic
 DG01677  Alkylating agent
  DG01678  Nitrogen mustard analog
Remark
ATC code: L01AA03
Chemical structure group: DG00676
Product (DG00676): D00369<JP> D08173<US>
Efficacy
Antineoplastic, Alkylating agent
  Disease
Multiple myeloma [DS:H00010]
Comment
Nitrogen mustard analogs
Target
DNA
Interaction
Structure map
map07040  Antineoplastics - alkylating agents
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01A ALKYLATING AGENTS
    L01AA Nitrogen mustard analogues
     L01AA03 Melphalan
      D08173  Melphalan hydrochloride <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Alkylating Agents
   Nitrogen Mustards
    Melphalan
     D08173  Melphalan hydrochloride
Drug groups [BR:br08330]
 Antineoplastic
  DG01677  Alkylating agent
   DG01678  Nitrogen mustard analog
    DG00676  Melphalan
     D08173  Melphalan hydrochloride
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08173
Drug groups [BR:br08330]
 Antineoplastic
  DG01677  Alkylating agent
   DG01678  Nitrogen mustard analog
    DG00676  Melphalan
Other DBs
CAS: 3223-07-2
PubChem: 96024863
LigandBox: D08173
NIKKAJI: J244.776B
LinkDB
KCF data

ATOM        20
            1   C8y C    25.9700  -17.5700
            2   N1c N    27.1600  -18.2700
            3   C8x C    24.7100  -18.2700
            4   C8x C    25.9700  -16.1700
            5   C1b C    27.1600  -19.6700
            6   C1b C    28.3500  -17.5700
            7   C8x C    23.5200  -17.5700
            8   C8x C    24.7100  -15.4700
            9   C8y C    23.5200  -16.1700
            10  C1b C    22.3300  -15.4700
            11  C1c C    21.0700  -16.1700
            12  C6a C    19.8800  -15.4700
            13  N1a N    21.0700  -17.5700
            14  O6a O    18.6900  -16.1700
            15  O6a O    19.8800  -14.0700
            16  C1b C    28.3500  -16.1700
            17  X   Cl   29.6100  -15.4700
            18  C1b C    25.9000  -20.3700
            19  X   Cl   25.9000  -21.7700
            20  X   Cl   31.2900  -19.3900
BOND        19
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 2
            8     7   9 2
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   11  13 1 #Down
            13   12  14 1
            14   12  15 2
            15    8   9 1
            16    6  16 1
            17   16  17 1
            18    5  18 1
            19   18  19 1

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