| Entry |
|
|---|
| Name |
Nordazepam (INN);
Calmday (TN) |
|---|
| Formula |
C15H11ClN2O
|
|---|
| Exact mass |
270.0560
|
|---|
| Mol weight |
270.71
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01567 GABA-A receptor agonist
DG01914 Anxiolytics, benzodiazepine derivatives
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Antianxiety |
|---|
| Comment |
Benzodiazepine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05B ANXIOLYTICS
N05BA Benzodiazepine derivatives
N05BA16 Nordazepam
D08283 Nordazepam (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01567 GABA-A receptor agonist
D08283 Nordazepam
DG01914 Anxiolytics, benzodiazepine derivatives
D08283 Nordazepam
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
D08283 Nordazepam
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D08283 Nordazepam
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D08283 Nordazepam (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08283
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
D08283
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 19
1 C2y C 25.6900 -16.7300
2 C8y C 24.8500 -15.6100
3 C8y C 25.2000 -14.2800
4 N1x N 26.4600 -13.7200
5 N2x N 27.0900 -16.7300
6 C5x C 27.7200 -14.3500
7 C1x C 28.0000 -15.6800
8 C8x C 24.2200 -13.3000
9 C8x C 22.8200 -13.7200
10 C8y C 22.5400 -15.0500
11 C8x C 23.5200 -16.0300
12 O5x O 28.7700 -13.3700
13 X Cl 21.1400 -15.4700
14 C8y C 25.0600 -17.9900
15 C8x C 23.6600 -17.9900
16 C8x C 22.9600 -19.2500
17 C8x C 23.6600 -20.3700
18 C8x C 25.0600 -20.3700
19 C8x C 25.7600 -19.2500
BOND 21
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 6 12 2
14 10 13 1
15 1 14 1
16 14 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 14 19 2
|
|---|
