| Entry |
|
|---|
| Name |
Venlafaxine (INN);
Efectin (TN) |
|---|
| Formula |
C17H27NO2
|
|---|
| Exact mass |
277.2042
|
|---|
| Mol weight |
277.40
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00959): | D00821<JP/US> D12403<US> |
|
|---|
| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
|---|
| Comment |
serotonin norepinephrine reuptake inhibitor (SNRI)
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]; CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX16 Venlafaxine
D08670 Venlafaxine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)
DG00959 Venlafaxine
D08670 Venlafaxine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00959 Venlafaxine
D08670 Venlafaxine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00959 Venlafaxine
D08670 Venlafaxine
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D08670 Venlafaxine (INN)
SLC6A4 (HTT)
D08670 Venlafaxine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08670
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)
DG00959 Venlafaxine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00959 Venlafaxine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00959 Venlafaxine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 20
1 C8x C 25.1300 -22.1900
2 C8y C 25.1300 -23.5900
3 C8x C 26.3900 -24.2900
4 C8x C 27.5800 -23.5900
5 C8y C 27.5800 -22.1900
6 C8x C 26.3900 -21.4900
7 C1x C 30.0300 -23.5900
8 C1z C 30.0300 -22.1900
9 C1c C 28.7700 -21.4900
10 C1x C 31.2200 -24.2900
11 C1x C 32.4100 -23.5900
12 C1x C 32.4100 -22.1900
13 C1x C 31.2200 -21.4900
14 O2a O 23.9400 -24.2900
15 C1a C 22.7500 -23.5900
16 C1b C 28.7700 -20.0900
17 O1a O 30.0300 -20.7900
18 N1c N 27.5800 -19.3900
19 C1a C 26.3900 -20.0900
20 C1a C 27.5800 -17.9900
BOND 21
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 8 13 1
15 2 14 1
16 14 15 1
17 9 16 1
18 8 17 1
19 16 18 1
20 18 19 1
21 18 20 1
|
|---|
