KEGG   DRUG: Platycodon fluidextract, glycyrrhiza extract, plantago herb extract, peony root extract and dihydrocodeine phosphate
Entry
D08697            Mixture   Drug                                   
Name
Platycodon fluidextract, glycyrrhiza extract, plantago herb extract, peony root extract and dihydrocodeine phosphate;
Opisezol codeine (TN)
Component
Platycodon fluidextract [DR:D06812], Glycyrrhiza extract [DR:D06811], Plantago herb extract [DR:D04333], Peony root extract [DR:D06739], Dihydrocodeine phosphate [DR:D01481]
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
  DG03189  UGT2B4 substrate
  DG03190  UGT2B7 substrate
Efficacy
Antitussive, Expectorant
Comment
Dihydrocodeine phosphate is metabolized by UGT2B7, UGT2B4 with some contribution from CYP3A4 and CYP2D6.
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B4 [HSA:7363]; CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D08697  Platycodon fluidextract, glycyrrhiza extract, plantago herb extract, peony root extract and dihydrocodeine phosphate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D08697  Platycodon fluidextract, glycyrrhiza extract, plantago herb extract, peony root extract and dihydrocodeine phosphate
  DG02924  UGT substrate
   DG03189  UGT2B4 substrate
    D08697  Platycodon fluidextract, glycyrrhiza extract, plantago herb extract, peony root extract and dihydrocodeine phosphate
   DG03190  UGT2B7 substrate
    D08697  Platycodon fluidextract, glycyrrhiza extract, plantago herb extract, peony root extract and dihydrocodeine phosphate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08697
Other DBs
PubChem: 96025380
LinkDB

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