| Entry |
|
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| Name |
Saxagliptin (USAN/INN) |
|---|
| Formula |
C18H25N3O2
|
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| Exact mass |
315.1947
|
|---|
| Mol weight |
315.41
|
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| Structure |
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| Simcomp |
|
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| Class |
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01601 DPP-4 inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02925 CYP3A5 substrate
|
|---|
| Remark |
| Product (DG00119): | D09753<JP/US> D10262<US> |
| Product (mixture): | D10263<US> D10826<US> |
|
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| Efficacy |
Antidiabetic, Dipeptidyl peptidase-4 (DPP-4) inhibitor |
|---|
| Comment |
Treatment of Type II diabetes mellitus and metabolic syndrome
|
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| Target |
|
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| Pathway |
| hsa04974 | Protein digestion and absorption |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]
|
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BH Dipeptidyl peptidase 4 (DPP-4) inhibitors
A10BH03 Saxagliptin
D08996 Saxagliptin (USAN/INN)
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01601 DPP-4 inhibitor
DG00119 Saxagliptin
D08996 Saxagliptin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00119 Saxagliptin
D08996 Saxagliptin
DG02925 CYP3A5 substrate
DG00119 Saxagliptin
D08996 Saxagliptin
Target-based classification of drugs [BR:br08310]
Peptidases and inhibitors
Serine peptidases
Prolyl oligopeptidase family
DPP4 (CD26)
D08996 Saxagliptin (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08996
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01601 DPP-4 inhibitor
DG00119 Saxagliptin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00119 Saxagliptin
DG02925 CYP3A5 substrate
DG00119 Saxagliptin
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 23
1 C1z C 23.5200 -27.9300
2 C1x C 22.8200 -29.3300
3 C1y C 22.8200 -30.5900
4 C1y C 22.3300 -29.8900
5 C1z C 24.6400 -29.8900
6 C1x C 21.2800 -31.0100
7 C1x C 23.9400 -31.5700
8 C1x C 22.3300 -28.5600
9 C1x C 23.5200 -30.5200
10 C1x C 24.6400 -28.5600
11 C1c C 23.5200 -26.5300
12 C5a C 24.7100 -25.8300
13 N1a N 22.3300 -25.8300
14 N1y N 25.9000 -26.5300
15 O5a O 24.7100 -24.4300
16 C1y C 26.3900 -27.8600
17 C1y C 27.7900 -27.8600
18 C1x C 28.2100 -26.4600
19 C1y C 27.0200 -25.6900
20 C3b C 27.0200 -24.2900
21 N3a N 27.0200 -22.8900
22 O1a O 26.0400 -29.8900
23 C1x C 27.0900 -29.0500
BOND 27
1 1 2 1
2 2 3 1
3 8 4 1
4 4 9 1
5 9 5 1
6 5 10 1
7 10 1 1
8 1 8 1
9 3 6 1
10 3 7 1
11 4 6 1
12 5 7 1
13 1 11 1
14 11 12 1
15 11 13 1 #Down
16 12 14 1
17 12 15 2
18 14 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 14 19 1
23 19 20 1 #Down
24 20 21 3
25 5 22 1
26 17 23 1
27 23 16 1
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