| Entry |
|
|---|
| Name |
Amonafide (USAN) |
|---|
| Formula |
C16H17N3O2
|
|---|
| Exact mass |
283.1321
|
|---|
| Mol weight |
283.32
|
|---|
| Structure |
|
|---|
| Class |
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antineoplastic, Topoisomerase II inhibitor |
|---|
| Comment |
Treatment of secondary acute myeloid leukemia (sAML)
|
|---|
| Target |
|
|---|
| Brite |
Drug groups [BR:br08330]
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG01268 Amonafide
D10090 Amonafide
Target-based classification of drugs [BR:br08310]
Enzymes
Isomerases (EC5)
DNA topoisomerase
TOP2
D10090 Amonafide (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG01268 Amonafide
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 21
1 N1y N 19.1100 -22.5400
2 C1b C 20.5100 -22.5400
3 C1b C 21.2100 -23.7524
4 N1c N 22.6098 -23.7524
5 C1a C 23.3003 -24.9480
6 C1a C 23.3196 -22.5232
7 C5x C 18.4100 -21.3276
8 C8y C 17.0100 -21.3276
9 C8y C 16.3100 -22.5400
10 C8y C 17.0100 -23.7524
11 C5x C 18.4100 -23.7524
12 C8y C 14.9100 -22.5400
13 C8x C 14.2100 -23.7524
14 C8x C 14.9100 -24.9649
15 C8x C 16.3100 -24.9649
16 C8x C 16.3100 -20.1151
17 C8y C 14.9100 -20.1151
18 C8x C 14.2100 -21.3276
19 N1a N 14.1990 -18.8840
20 O5x O 19.1004 -20.1321
21 O5x O 19.1004 -24.9479
BOND 23
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 4 6 1
6 1 7 1
7 7 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 1 11 1
12 9 12 2
13 12 13 1
14 13 14 2
15 14 15 1
16 10 15 2
17 8 16 2
18 16 17 1
19 17 18 2
20 18 12 1
21 17 19 1
22 7 20 2
23 11 21 2
|
|---|
