| Entry |
|
|---|
| Name |
Amonafide l-malate (USAN) |
|---|
| Formula |
C16H17N3O2. C4H6O5
|
|---|
| Exact mass |
417.1536
|
|---|
| Mol weight |
417.41
|
|---|
| Structure |
|
|---|
| Class |
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antineoplastic, Topoisomerase II inhibitor |
|---|
| Comment |
Treatment of secondary acute myeloid leukemia (sAML)
|
|---|
| Target |
|
|---|
| Brite |
Drug groups [BR:br08330]
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG01268 Amonafide
D10091 Amonafide l-malate
Target-based classification of drugs [BR:br08310]
Enzymes
Isomerases (EC5)
DNA topoisomerase
TOP2
D10091 Amonafide l-malate (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01529 Topoisomerase inhibitor
DG01527 Topoisomerase II inhibitor
DG01268 Amonafide
|
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| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 30
1 N1y N 24.8500 -21.7700
2 C1b C 26.2500 -21.7700
3 C1b C 26.9500 -23.0300
4 N1c N 28.3500 -23.0300
5 C1a C 29.0500 -24.2200
6 C1a C 29.0500 -21.7700
7 C5x C 24.1500 -20.5800
8 C8y C 22.7500 -20.5800
9 C8y C 22.0500 -21.7700
10 C8y C 22.7500 -23.0300
11 C5x C 24.1500 -23.0300
12 C8y C 20.6500 -21.7700
13 C8x C 19.9500 -23.0300
14 C8x C 20.6500 -24.2200
15 C8x C 22.0500 -24.2200
16 C8x C 22.0500 -19.3900
17 C8y C 20.6500 -19.3900
18 C8x C 19.9500 -20.5800
19 N1a N 19.9500 -18.1300
20 O5x O 24.8500 -19.3900
21 O5x O 24.8500 -24.2200
22 O6a O 32.5500 -20.8600
23 C6a C 33.7624 -21.5600
24 C1c C 34.9579 -20.8696
25 O6a O 33.7625 -22.9598
26 C1b C 36.1453 -21.5551
27 C6a C 37.3365 -20.8671
28 O6a O 38.5260 -21.5538
29 O6a O 37.3365 -19.4603
30 O1a O 34.9580 -19.4603
BOND 31
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 4 6 1
6 1 7 1
7 7 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 1 11 1
12 9 12 2
13 12 13 1
14 13 14 2
15 14 15 1
16 10 15 2
17 8 16 2
18 16 17 1
19 17 18 2
20 18 12 1
21 17 19 1
22 7 20 2
23 11 21 2
24 22 23 1
25 23 24 1
26 23 25 2
27 24 26 1
28 26 27 1
29 27 28 1
30 27 29 2
31 24 30 1 #Up
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