| Entry |
|
|---|
| Name |
Asunaprevir (JAN/USAN);
Sunvepra (TN) |
|---|
| Abbr |
ASV |
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| Formula |
C35H46ClN5O9S
|
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| Exact mass |
747.2705
|
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| Mol weight |
748.29
|
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| Structure |
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| Class |
Antiviral
DG03198 Anti-HCV agent
DG02001 HCV NS3/4A protease inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
Transporter substrate
DG01665 ABCB1 substrate
DG02856 SLCO1B1 substrate
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG02865 SLCO1B1 inhibitor
DG02907 SLCO1B3 inhibitor
|
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| Remark |
|
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| Efficacy |
Antiviral, Protease inhibitor |
|---|
| Comment |
Treatment of hepatitis C
|
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| Target |
|
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| Pathway |
|
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| Metabolism |
|
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
CYP induction: CYP3A4 [HSA: 1576]
Transporter inhibition: SLCO1B1 [HSA: 10599], SLCO1B3 [HSA: 28234], ABCB1 [HSA: 5243]
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AP Antivirals for treatment of HCV infections
J05AP06 Asunaprevir
D10093 Asunaprevir (JAN/USAN)
Drug groups [BR:br08330]
Antiviral
DG03198 Anti-HCV agent
DG02001 HCV NS3/4A protease inhibitor
D10093 Asunaprevir
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
D10093 Asunaprevir
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
D10093 Asunaprevir
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
D10093 Asunaprevir
Transporter substrate
DG01665 ABCB1 substrate
D10093 Asunaprevir
DG02856 SLCO1B1 substrate
D10093 Asunaprevir
Transporter inhibitor
DG01622 ABCB1 inhibitor
D10093 Asunaprevir
DG02865 SLCO1B1 inhibitor
D10093 Asunaprevir
DG02907 SLCO1B3 inhibitor
D10093 Asunaprevir
Antimicrobials [BR:br08307]
Antivirals
Polyprotein cleavage inhibitor
HCV NS3/4A inhibitor
D10093 Asunaprevir (JAN/USAN)
Antimicrobials abbreviations [BR:br08327]
Antivirals
Polyprotein cleavage inhibitor
HCV NS3/4A inhibitor
D10093 Asunaprevir (JAN/USAN)
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D10093
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10093
Drug transporters
D10093
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 51
1 C8y C 14.3982 -18.8068
2 C8y C 14.3982 -20.1980
3 C8y C 15.5807 -20.8935
4 C8x C 16.8327 -20.1980
5 N5x N 16.8327 -18.8068
6 C8y C 15.5807 -18.1113
7 C8x C 13.2158 -18.1113
8 C8y C 11.9637 -18.8068
9 C8x C 11.9637 -20.1980
10 C8x C 13.2158 -20.8935
11 X Cl 10.7813 -18.1113
12 O2a O 15.5807 -22.2847
13 C1a C 14.3982 -22.9802
14 O2a O 15.5807 -16.7201
15 C1y C 16.7631 -16.0246
16 C1x C 18.0847 -16.4419
17 C1y C 18.8498 -15.3290
18 N1y N 18.0152 -14.2161
19 C1x C 16.7631 -14.7030
20 C5a C 20.2410 -15.2594
21 O5a O 20.9365 -16.4419
22 N1b N 20.9365 -14.0770
23 C1z C 23.0928 -14.0770
24 C5a C 18.0152 -12.8250
25 O5a O 19.1976 -12.1294
26 C1c C 16.8327 -12.1294
27 N1b N 15.6502 -12.8250
28 C7a C 14.4678 -12.1294
29 O7a O 13.2853 -12.8250
30 O6a O 14.4678 -10.7383
31 C1d C 12.1029 -12.1294
32 C1a C 10.9204 -12.8250
33 C1a C 12.1029 -10.7383
34 C1a C 10.8508 -11.4338
35 C1d C 16.8327 -10.7383
36 C1a C 15.6502 -10.0427
37 C1a C 18.0152 -10.0427
38 C1a C 16.8327 -9.3471
39 C1x C 24.3448 -14.8421
40 C1y C 24.3448 -13.4510
41 C2b C 25.1099 -12.2685
42 C2a C 26.5011 -12.2685
43 C5a C 23.0928 -15.4681
44 O5a O 24.2753 -16.1637
45 N1b N 21.9103 -16.1637
46 S4a S 21.9103 -17.5548
47 O3c O 23.3015 -17.5548
48 O3c O 20.5192 -17.5548
49 C1y C 21.9103 -18.9460
50 C1x C 21.2148 -20.1284
51 C1x C 22.6059 -20.1284
BOND 55
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 2 10 1
12 8 11 1
13 3 12 1
14 12 13 1
15 6 14 1
16 15 14 1 #Up
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 15 19 1
22 17 20 1 #Down
23 20 21 2
24 20 22 1
25 22 23 1
26 18 24 1
27 24 25 2
28 26 24 1 #Up
29 26 27 1
30 27 28 1
31 28 29 1
32 28 30 2
33 29 31 1
34 31 32 1
35 31 33 1
36 31 34 1
37 26 35 1
38 35 36 1
39 35 37 1
40 35 38 1
41 23 39 1
42 39 40 1
43 40 23 1
44 40 41 1 #Down
45 41 42 2
46 23 43 1 #Down
47 43 44 2
48 43 45 1
49 45 46 1
50 46 47 2
51 46 48 2
52 46 49 1
53 50 51 1
54 51 49 1
55 49 50 1
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