| Entry |
|
|---|
| Name |
Esflurbiprofen (JAN) |
|---|
| Formula |
C15H13FO2
|
|---|
| Exact mass |
244.0900
|
|---|
| Mol weight |
244.26
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
|---|
| Remark |
| Product (DG00755): | D00330<JP/US> D01475<JP> D02290<US> |
| Product (mixture): | D10746<JP> |
|
|---|
| Efficacy |
Analgesic, Anti-inflammatory, COX inhibitor |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AE Propionic acid derivatives
M01AE09 Flurbiprofen
D10254 Esflurbiprofen (JAN)
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA19 Flurbiprofen
D10254 Esflurbiprofen (JAN)
M02AA29 Esflurbiprofen
D10254 Esflurbiprofen (JAN)
R RESPIRATORY SYSTEM
R02 THROAT PREPARATIONS
R02A THROAT PREPARATIONS
R02AX Other throat preparations
R02AX01 Flurbiprofen
D10254 Esflurbiprofen (JAN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC04 Flurbiprofen
D10254 Esflurbiprofen (JAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00755 Flurbiprofen
D10254 Esflurbiprofen
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00755 Flurbiprofen
D10254 Esflurbiprofen
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D10254 Esflurbiprofen (JAN)
PTGS2 (COX2)
D10254 Esflurbiprofen (JAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10254
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00755 Flurbiprofen
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00755 Flurbiprofen
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 18
1 C8x C 9.1000 -18.1300
2 C8x C 9.1000 -19.5300
3 C8x C 10.3124 -20.2300
4 C8x C 11.5249 -19.5300
5 C8y C 11.5249 -18.1300
6 C8x C 10.3124 -17.4300
7 C8y C 12.7560 -17.4190
8 C8y C 13.9612 -18.1147
9 C8x C 15.1735 -17.4146
10 C8y C 15.1735 -16.0146
11 C8x C 13.9683 -15.3189
12 C8x C 12.7559 -16.0190
13 X F 13.9616 -19.5296
14 C1c C 16.3914 -15.3112
15 C6a C 17.6034 -16.0107
16 C1a C 16.3911 -13.9300
17 O6a O 18.7823 -15.3298
18 O6a O 17.6040 -17.4296
BOND 19
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 11 12 2
13 7 12 1
14 8 13 1
15 10 14 1
16 14 15 1
17 14 16 1 #Down
18 15 17 1
19 15 18 2
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