| Entry |
|
|---|
| Name |
Pitolisant hydrochloride (USAN);
Wakix (TN) |
|---|
| Product |
|
|---|
| Formula |
C17H26ClNO. HCl
|
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| Exact mass |
331.1470
|
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| Mol weight |
332.30
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG03021): | D11490<US> |
|
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| Efficacy |
Nootropic, H3 receptor inverse agonist/antagonist |
|---|
| Disease |
|
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| Comment |
Treatment of narcolepsy
|
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]; CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07X OTHER NERVOUS SYSTEM DRUGS
N07XX Other nervous system drugs
N07XX11 Pitolisant
D11490 Pitolisant hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
Sleep Disorder Agents
Wakefulness Promoting Agents
Pitolisant
D11490 Pitolisant hydrochloride (USAN)
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG03021 Pitolisant
D11490 Pitolisant hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03021 Pitolisant
D11490 Pitolisant hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH3
D11490 Pitolisant hydrochloride (USAN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11490
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG03021 Pitolisant
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03021 Pitolisant
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 21
1 C1x C 26.4831 -15.4835
2 C1x C 26.4831 -16.8847
3 C1x C 25.2921 -17.5854
4 C1x C 24.0310 -16.8847
5 N1y N 24.0310 -15.4835
6 C1x C 25.2921 -14.7829
7 C1b C 22.8399 -14.7829
8 C1b C 21.6489 -15.4835
9 C1b C 20.4579 -14.7829
10 O2a O 19.2668 -15.4835
11 C1b C 18.0758 -14.7829
12 C1b C 16.8847 -15.4835
13 C1b C 15.6937 -14.7829
14 C8y C 14.4326 -15.4835
15 C8x C 14.4326 -16.8847
16 C8x C 13.1715 -17.5854
17 C8y C 11.9805 -16.8847
18 C8x C 11.9805 -15.4835
19 C8x C 13.1715 -14.7829
20 X Cl 10.7894 -17.5854
21 X Cl 28.3500 -16.1700
BOND 21
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 14 15 2
16 15 16 1
17 16 17 2
18 17 18 1
19 18 19 2
20 14 19 1
21 17 20 1
|
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