KEGG   DRUG: Duligotuzumab
Entry
D11750                      Drug                                   
Name
Duligotuzumab (USAN)
Formula
C6416H9920N1704O2028S44
Exact mass
144695.3204
Mol weight
144784.56
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTLS GDWIHWVRQA PGKGLEWVGE ISAAGGYTDY
ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCARES RVSFEAAMDY WGQGTLVTVS
SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKKVE PKSCDKTHTC PPCPAPELLG
GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRE
EMTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG K
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQNIA TDVAWYQQKP GKAPKLLIYS ASFLYSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SEPEPYTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H148-H204, H224-L214, H230-H'230, H233-H'233, H265-H325, H371-H429, H'22-H'96, H'148-H'204, H'224-L'214, H'265-H'325, H'371-H'429, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic
  Type
Monoclonal antibody, bispecific antibody
Comment
Treatment of solid tumors
Target
EGFR [HSA:1956] [KO:K04361]
ERBB3 (HER3) [HSA:2065] [KO:K05084]
  Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04151  PI3K-Akt signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    EGFR
     D11750  Duligotuzumab (USAN)
    ERBB3 (HER3)
     D11750  Duligotuzumab (USAN)
Other DBs
CAS: 1314238-96-4
PubChem: 405226616
LinkDB

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