KEGG   DRUG: Macitentan and tadalafil
Entry
D12963            Mixture   Drug                                   
Name
Macitentan and tadalafil;
Opsynvi (TN);
Yuvanci (TN)
Product
OPSYNVI (Actelion Pharmaceuticals US)
Component
Macitentan [DR:D10135], Tadalafil [DR:D02008]
Class
Metabolizing enzyme substrate
 DG02918  CYP2C8 substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 2190
ATC code: C02KX54
Product: D12963<JP/US>
Efficacy
Antihypertensive
  Disease
Pulmonary arterial hypertension [DS:H01621]
Comment
Macitentan is metabolized by CYP3A4 with some contribution from CYP2C8, CYP2C9 and CYP2C19.
Tadalafil is a substrate for CYP3A.
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]; CYP2C8 [HSA:1558], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02K OTHER ANTIHYPERTENSIVES
    C02KX Antihypertensives for pulmonary arterial hypertension
     C02KX54 Macitentan and tadalafil
      D12963  Macitentan and tadalafil <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Prostacyclin Vasodilators
    Macitentan/ Tadalafil
     D12963  Macitentan and tadalafil
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D12963  Macitentan and tadalafil
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   D12963  Macitentan and tadalafil
  DG01642  CYP2C9 substrate
   D12963  Macitentan and tadalafil
  DG01639  CYP2C19 substrate
   D12963  Macitentan and tadalafil
  DG01633  CYP3A/CYP3A4 substrate
   D12963  Macitentan and tadalafil
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D12963
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D12963
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12963
Other DBs
PubChem: 503268983
LinkDB

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