KEGG ORTHOLOGY: K00314

ORTHOLOGY: K00314

Entry

K00314                      KO

Symbol

SARDH

Name

sarcosine dehydrogenase [EC:1.5.8.3]

Pathway

map00260

Glycine, serine and threonine metabolism

map00670

One carbon pool by folate

map01100

Metabolic pathways

Module

M00974

Betaine metabolism, animals, betaine => glycine

Reaction

R00611

sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating)

Disease

H02657

Sarcosinemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K00314  SARDH; sarcosine dehydrogenase
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K00314  SARDH; sarcosine dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.8  With a flavin or flavoprotein as acceptor
    1.5.8.3  sarcosine dehydrogenase
     K00314  SARDH; sarcosine dehydrogenase

Other DBs

COG:	COG0404 COG0665

GO:

0008480

Genes

HSA:	1757(SARDH)

PTR:	464828(SARDH)

PPS:	100986136(SARDH)

GGO:	101126679(SARDH)

PON:	100172073(SARDH)

PPYG:

129044476(SARDH)

NLE:	100581547(SARDH)

HMH:	116475832(SARDH)

SSYN:

129478713(SARDH)

MCC:	713289(SARDH)

MCF:	102139165(SARDH)

MTHB:

126936903

MNI:	105471877(SARDH)

CSAB:

103239675(SARDH)

CATY:

105578092 105580522(SARDH)

PANU:

101015658(SARDH)

TGE:	112608502(SARDH) 112632442

MLEU:

105547817(SARDH)

RRO:	104669713(SARDH)

RBB:	108513254(SARDH)

TFN:	117099201(SARDH)

PTEH:

111524002(SARDH)

CANG:

105503971(SARDH)

CJC:	100396240(SARDH)

SBQ:	101038416(SARDH)

CIMI:

108292304(SARDH)

ANAN:

105712262(SARDH)

CSYR:

103273376(SARDH)

MMUR:

105880753(SARDH)

LCAT:

123645984(SARDH)

PCOQ:

105826695(SARDH)

OGA:	100950320(SARDH)

MMU:	192166(Sardh)

MCAL:

110310298(Sardh)

MPAH:

110318656(Sardh)

RNO:	114123(Sardh)

MCOC:

116089881(Sardh)

ANU:	117704184(Sardh)

ASYL:

127685117(Sardh)

MUN:	110557507(Sardh)

CGE:	100761121(Sardh)

MAUA:

101837481(Sardh)

PROB:

127222657(Sardh)

PLEU:

114684225(Sardh)

MORG:

121462827(Sardh)

MFOT:

126509210

AAMP:

119818433(Sardh)

NGI:	103742819(Sardh)

HGL:	101717296(Sardh)

CPOC:

100718504(Sardh)

CCAN:

109695047(Sardh)

DORD:

105995659(Sardh)

DSP:	122108903(Sardh)

PLOP:

125353290(Sardh)

NCAR:

124964225

MMMA:

107159138(Sardh)

ITI:	101967980(Sardh)

OPI:	101531608(SARDH)

TUP:	102468288(SARDH)

GVR:	103581999 103607776

CFA:	491277(SARDH)

CLUD:

112677395(SARDH)

VVP:	112935890(SARDH)

VLG:	121472927(SARDH)

NPO:	129505342(SARDH)

AML:	100477821(SARDH)

UMR:	103679941(SARDH)

UAH:	113266576(SARDH)

UAR:	123775645(SARDH)

ELK:

111146213

LLV:

125083188

MPUF:

101689810(SARDH)

MNP:	132024271(SARDH)

MLK:	131812505(SARDH)

NVS:	122917099(SARDH)

ORO:	101363163(SARDH)

EJU:	114200995(SARDH)

ZCA:	113933946(SARDH)

MLX:	118017541(SARDH)

NSU:	110581413(SARDH)

LWW:	102727859(SARDH)

FCA:	101082702(SARDH)

PYU:	121021238(SARDH)

PBG:	122475224(SARDH)

PVIV:

125150065(SARDH)

LRUF:

124522436

LGF:	123593787(SARDH)

AJU:

106988257

PTG:	102959524(SARDH)

PPAD:

109258271(SARDH)

PUC:

125923035

PLEZ:

122204462(SARDH)

HHV:	120247321(SARDH)

BTA:	614603(SARDH)

BOM:	102286478(SARDH)

BIU:	109566616(SARDH)

BBUB:

102407897(SARDH)

BBIS:

104983331(SARDH)

CHX:	102176539(SARDH)

OAS:	101110407(SARDH)

BTAX:

128056075(SARDH)

CSUM:

138091472(SARDH)

ODA:	120852212(SARDH)

CCAD:

122442336(SARDH)

MREE:

136163626(SARDH)

OVR:	110134115(SARDH)

MBEZ:

129539422(SARDH)

SSC:	100154338(SARDH)

CFR:	102524074(SARDH)

CBAI:

105068574(SARDH)

CDK:	105102809(SARDH)

VPC:	102539312(SARDH)

BACU:

103001806(SARDH)

BMUS:

118896710(SARDH)

LVE:	103082579(SARDH)

OOR:	101269445(SARDH)

LALB:

132523193(SARDH)

DLE:	111177031(SARDH)

PCAD:

114487445

PSIU:

116755110(SARDH)

NASI:

112411329(SARDH)

ECB:	100069193(SARDH)

EPZ:	103564041(SARDH)

EAI:	106845348(SARDH)

MYB:	102263827(SARDH)

MYD:	102763367(SARDH)

MMYO:

118666898(SARDH)

MDT:	132212529(SARDH)

MYUM:

139020643(SARDH)

PKL:	118708904(SARDH)

EFUS:

103296146(SARDH)

MNA:	107524617(SARDH)

DRO:	112306574(SARDH)

SHON:

118980108(SARDH)

AJM:	119036072(SARDH)

PDIC:

114502600(SARDH)

PHAS:

123823382(SARDH)

MMF:	118629383(SARDH)

PPAM:

129079162(SARDH)

HAI:	109381141(SARDH)

RFQ:	117032350(SARDH)

PALE:

102882489(SARDH)

PGIG:

120618873(SARDH)

PVP:	105308211(SARDH)

RAY:	107506266(SARDH)

MJV:	108388196(SARDH)

TOD:	119231222(SARDH)

SARA:

101550003(SARDH)

SFUM:

130040729(SARDH)

SETR:

126009328(SARDH)

LAV:

100677707

TMU:

101344177

ETF:	101656739(SARDH)

DNM:	101446999(SARDH)

MDO:	100018850(SARDH)

GAS:	123237208(SARDH)

SHR:	100925921(SARDH)

AFZ:

127550957

PCW:	110205373(SARDH)

TVP:	118841799(SARDH)

PBRV:

138147067(SARDH)

OAA:	100073946(SARDH)

TACU:

119926959(SARDH)

GGA:	417146(SARDH)

PCOC:

116234304(SARDH)

MGP:	100544931(SARDH)

CJO:	107321866(SARDH)

TPAI:

128073307(SARDH)

LMUT:

125702507(SARDH)

NMEL:

110406941(SARDH)

APLA:

101793569(SARDH)

ACYG:

106044083(SARDH)

CATA:

118252264(SARDH)

AFUL:

116496886(SARDH)

TGU:	100221431(SARDH)

LSR:	110477625(SARDH)

SCAN:

103819130(SARDH)

PMOA:

120512467(SARDH)

OTC:	121337015(SARDH)

PRUF:

121362436(SARDH)

ATRC:

139603340(SARDH)

GFR:	102042792(SARDH)

FAB:	101807275(SARDH)

OMA:	130260255(SARDH)

PHI:	102100623(SARDH)

PMAJ:

107211981(SARDH)

CCAE:

111937046(SARDH)

CCW:	104688488(SARDH)

ACOE:

138119525(SARDH)

ETL:	114059122(SARDH)

ZAB:	102072207(SARDH)

ZLE:	135454925(SARDH)

ACHL:

103807317(SARDH)

SVG:	106851371(SARDH)

MMEA:

130576689(SARDH)

HRT:	120761614(SARDH)

SATI:

136369787(SARDH)

CCIC:

134051727(SARDH)

FPG:	101910621(SARDH)

FCH:	102055614(SARDH)

CCRI:

104161252(SARDH)

NNT:	104401845(SARDH)

SHAB:

115617139(SARDH)

ACUN:

113486534(SARDH)

TALA:

104358507(SARDH)

ACHC:

115335020(SARDH)

HLE:	104834021(SARDH)

AGEN:

126052419

HHAR:

128154650(SARDH)

GCL:

127023702

CSTI:

104559665(SARDH)

LDI:	104353408(SARDH)

DPUB:

104296481(SARDH)

PPUS:

135190155(SARDH)

AVIT:

104275305(SARDH)

BRHI:

104496130(SARDH)

EGZ:	104129358(SARDH)

NNI:	104023287(SARDH)

PCRI:

104028748(SARDH)

PADL:

103915344(SARDH)

AFOR:

103905337(SARDH)

CLV:	102089708(SARDH)

MUI:	104537222(SARDH)

PGUU:

104462250(SARDH)

EHS:	104510227(SARDH)

CMAC:

104484056(SARDH)

CUCA:

104066940(SARDH)

TEO:	104375627(SARDH)

BREG:

104632937(SARDH)

OHA:	104329475(SARDH)

ACAR:

104524269(SARDH)

CPEA:

104389905(SARDH)

CVF:	104292890(SARDH)

RTD:	128917707(SARDH)

CRID:

134523874(SARDH)

AAM:	106484478(SARDH)

AROW:

112964334(SARDH)

NPD:	112955996(SARDH)

TGT:	104568109(SARDH)

DNE:	112979933(SARDH)

SCAM:

104138293(SARDH)

ASN:

102387705

AMJ:	102565496(SARDH)

CPOO:

109313993(SARDH)

GGN:	109293014(SARDH)

PSS:	102455800(SARDH)

CMY:	102936719(SARDH)

CCAY:

125623620(SARDH)

DCC:	119844196(SARDH)

CPIC:

101938284(SARDH)

TST:	117867214(SARDH)

CABI:

116817467(SARDH)

MRV:	120386569(SARDH)

ACS:	100567227 103281982(sardh)

ASAO:

132763715(SARDH)

PVT:	110089290(SARDH)

SUND:

121937135(SARDH)

PBI:

103065615

PMUR:

107291024(SARDH)

CTIG:

120310204(SARDH)

TSR:	106552855(SARDH)

PGUT:

117671326(SARDH)

APRI:

131186144(SARDH)

PTEX:

113448476(SARDH)

NSS:	113426289(SARDH)

VKO:	123035146(SARDH)

PMUA:

114588913(SARDH)

PRAF:

128406238(SARDH)

ZVI:	118083953(SARDH)

HCG:	128338781(SARDH)

GJA:	107106570(SARDH)

STOW:

125441578(SARDH)

EMC:	129342011(SARDH)

XLA:	108698171(sardh.L)

XTR:	100492087(sardh)

NPR:

108793117

RTEM:

120913855(SARDH)

BBUF:

120978222(SARDH)

BGAR:

122946102(SARDH)

PWL:	138301268(SARDH)

MUO:	115473063(SARDH)

GSH:	117368407(SARDH)

DRE:	394103(sardh)

SRX:	107713264 107744257

SANH:

107685122(sardh)

SGH:	107595553(sardh)

CAUA:

113109650 113109661

CGIB:

127966273

PTET:

122352742(sardh)

LROH:

127171925(sardh)

OMC:	131548321(sardh)

PPRM:

120482668(sardh)

RKG:	130073503(sardh)

MAMB:

125257695(sardh)

CIDE:

127521118

CERY:

137028883(sardh)

MASI:

127432966

TROS:

130546400(sardh)

TDW:	130411579(sardh)

MANU:

129447250(sardh)

PDAB:

135779599(sardh)

IPU:

108276635

IFU:	128620169 128620698(sardh)

PHYP:

113544041(sardh)

SMEO:

124393246(sardh)

TFD:	113653074(sardh)

TVC:	132863207(sardh)

CGAR:

128505517(sardh)

NGRA:

132873413(sardh)

TRN:	134332200(sardh)

AMEX:

103038491(sardh)

CMAO:

118824921(sardh)

EEE:	113576323(sardh)

CHAR:

105906040(sardh)

SPIL:

134101472(sardh)

TRU:	101066393(sardh)

TFS:	130517643(sardh)

TNG:	GSTEN00024728G001

LCO:	104923713(sardh)

NCC:	104968189(sardh)

TBEN:

117476396(sardh)

CGOB:

115016604(sardh)

PGEO:

117456399(sardh)

GACU:

117534085(sardh)

EMAC:

134868707(sardh)

ELY:	117270080(sardh)

EFO:	125905775(sardh)

PLEP:

121959519(sardh)

SLUC:

116034954(sardh)

ECRA:

117959051(sardh)

ESP:	116704714(sardh)

PFLV:

114571014(sardh)

GAT:	120832222(sardh)

PPUG:

119226499(sardh)

AFB:	129102463(sardh)

CLUM:

117740414(sardh)

PSWI:

130205130(sardh)

CANA:

137783708(sardh)

CVE:	137868856(sardh)

MSAM:

119914706(sardh)

SCHU:

122865194(sardh)

CUD:	121525654(sardh)

SPUL:

138601946(sardh)

LMIX:

132992305(sardh)

ALAT:

119030407(sardh)

ASTR:

137608325(sardh) 137608715

MZE:	101464347(sardh)

ONL:	100708425(sardh)

OAU:	116335193(sardh)

OLA:	101171504(sardh)

OML:	112162906(sardh)

CSAI:

133455326(sardh)

XMA:	102218956(sardh)

XCO:	114149434(sardh)

XHE:	116724090(sardh)

PRET:

103473627(sardh)

PFOR:

103147877(sardh)

PLAI:

106948297(sardh)

PMEI:

106921877(sardh)

GAF:	122847257(sardh)

PPRL:

129366447(sardh)

CVG:	107088710(sardh)

CTUL:

119782613(sardh)

GMU:	124872392(sardh)

NFU:	107372413(sardh)

KMR:	108232690(sardh)

ALIM:

106514558(sardh)

NWH:	119424550(sardh)

AOCE:

111567010(sardh)

EJA:	138206701(sardh)

BFRE:

138623727(sardh)

MCEP:

124996692(sardh)

CSEM:

103389066(sardh)

POV:	109626083(sardh)

SSEN:

122758351(sardh)

SSOE:

131446205(sardh)

HHIP:

117771594(sardh)

HSP:	118125404(sardh)

PPLT:

128424548(sardh)

SMAU:

118284742(sardh)

LCF:

108879253

SDU:	111238764(sardh)

SLAL:

111666073(sardh)

XGL:	120806360(sardh)

HCQ:	109517069(sardh)

SSCV:

125980042(sardh)

SBIA:

133490562(sardh)

PEE:	133414082(sardh)

PTAO:

133489894(sardh)

BPEC:

110174148(sardh)

MALB:

109963453(sardh)

BSPL:

114866771(sardh)

SJO:	128380397(sardh)

SSCO:

133995298(sardh)

GMH:	115541833(sardh)

SASA:

106561570(sardh)

STRU:

115159137(sardh)

OTW:	112235511(sardh)

OMY:	110523941(sardh)

OGO:	124048581(sardh)

ONE:	115127526(sardh)

OKI:	109868567(sardh)

OKE:	118387955(sardh)

OMM:	135517617(sardh)

OCLA:

139408909

SALP:

111961266(sardh)

SNH:	120026194(sardh)

CCLU:

121582864(sardh)

ELS:	105014778(sardh)

SFM:	108932522(sardh)

PKI:	111854167(sardh)

AANG:

118212851(sardh)

AROT:

135238911(sardh)

CCOG:

133142424(sardh)

LOC:	102683068(sardh)

PSPA:

121303520(sardh) 121307070

ARUT:

117396956 117422502

PSEX:

120535140(sardh)

LCM:	102358838(SARDH)

CMK:	103183089(sardh)

HOC:	132825979(sardh)

LERI:

129712112(sardh)

PMRN:

116953236(SARDH)

LRJ:	133354673(SARDH)

BFO:

118421387

BBEL:

109465509

CIN:	100179924 100182727 100184925

SCLV:

120326566 120326837 120326875 120343979

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:	100374616(Sardh)

PFLL:

139114475

DME:	Dmel_CG6385(Sardh)

DER:

6546660

DSE:

6609685

DSI:	Dsimw501_GD25443(Dsim_GD25443)

DYA:	Dyak_GE13964

DAN:

DSR:

DPO:

DPE:

DMN:	108159573 117193886

DWI:

6652181

DGR:

6562281

DMO:	Dmoj_GI23785

DAZ:

108610357

DNV:

115562207

DHE:

111600959

DVI:	6628364(Sardh)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:	119613729 119614622

CVJ:	135962334(Sardh)

GFS:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AALI:

ACOS:

AAG:	5565677 5572760

AALB:

109403674 109407988

ASUA:

134210618

CQU:	CpipJ_CPIJ004591 CpipJ_CPIJ016929

CPII:

120420098

CNS:	116345252 116348710 116349036

BCOO:

LLL:

PPAP:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:	105144562 105144729

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:	105673907(Sardh)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

136412885(Sardh)

EFOR:

136343711(Sardh)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

116169980 116169982 116172170

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_204504

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137929591(Sardh)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

113365503 113365504 113386018

CCRN:

123296798

CLEC:

106666323

HHAL:

106690642(Sardh)

MQU:

128992710

PHU:	Phum_PHUM213030

FOC:

113207710

TPAL:

117641156

ZNE:	110831180 110831181

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139690100(Sardh)

FCD:

110856220

DPX:	DAPPUDRAFT_308482

DMK:

116930444

DPZ:

124338461

PVM:	113821151 113822901

PJA:	122255467 122265981

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128701620(Sardh)

PTRU:

123508387 123508458

ESN:	126981425 126986885

MNZ:	135198650 135203034 135203035 135203036 135220766

MRJ:	136834857 136834858 136834860

PORN:

139765026 139765115(Sardh)

HAZT:

108675385

EAF:

111713614

LSM:	121119332(Sardh)

PPOI:

119103280

ISC:	8034007 8036170

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

CVS:	136986961(Sardh)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_53512

AAF:	AURANDRAFT_22613(SDH1)

SPAR:

SPRG_03481

EHX:	EMIHUDRAFT_97687

» show all

Reference

PMID:10444331

Authors

Eschenbrenner M, Jorns MS

Title

Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia.

Journal

Genomics 59:300-8 (1999)
DOI:10.1006/geno.1999.5886

Sequence

[hsa:1757]

LinkDB

DBGET integrated database retrieval system