KEGG ORTHOLOGY: K00543

ORTHOLOGY: K00543

Entry

K00543                      KO

Symbol

ASMT

Name

acetylserotonin O-methyltransferase [EC:2.1.1.4]

Pathway

map00380

Tryptophan metabolism

map01100

Metabolic pathways

Module

M00037

Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin

Reaction

R03130

S-adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase

R04905

S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K00543  ASMT; acetylserotonin O-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.4  acetylserotonin O-methyltransferase
     K00543  ASMT; acetylserotonin O-methyltransferase

Other DBs

GO:

0017096

Genes

HSA:

438(ASMT)

PTR:	107971195(ASMT)

PPS:	100968232(ASMT)

GGO:

129530055

PON:

129047217

PPYG:

129025102(ASMT)

NLE:	100594711(ASMT)

SSYN:

129475919(ASMT)

MCC:	574350(ASMT)

MCF:	102123281(ASMT)

MTHB:

126946854 126947141

MNI:	105478259(ASMT)

CSAB:

103232876(ASMT)

CATY:

105574778(ASMT)

PANU:

101016694(ASMT)

TGE:	112615123(ASMT)

MLEU:

105537122(ASMT)

RBB:	108516657(ASMT)

TFN:	117076215(ASMT)

CANG:

105516176(ASMT)

CJC:	100406578 118150897

CIMI:

108296371(ASMT)

ANAN:

105730447(ASMT)

MMUR:

105870820(ASMT)

LCAT:

123628068(ASMT)

PCOQ:

105820335(ASMT)

OGA:	100946414(ASMT)

MMU:	107626(Asmt)

MCAL:

110288766(Asmt)

MPAH:

110315745(Asmt)

RNO:	246281(Asmt)

ANU:	117695741(Asmt)

ASYL:

127676122(Asmt)

MUN:	110542401(Asmt)

CGE:

113838540

MAUA:

101839364(Asmt)

PROB:

127214765 127217575

MORG:

121443725 121444542 121445347

MFOT:

126495523

AAMP:

119826834

NGI:	103750116(Asmt)

HGL:	101697837(Asmt)

DORD:

106000184(Asmt)

DSP:	122102637 122102762

PLOP:

125345394(Asmt)

NCAR:

124972173

ITI:	101963266(Asmt)

OPI:	101532831(ASMT)

TUP:	102472243(ASMT)

GVR:	103586843(ASMT)

CFA:	100683688(ASMT)

CLUD:

112651992(ASMT)

VVP:	112908965(ASMT)

VLG:	121483444(ASMT)

NPO:	129518656(ASMT)

AML:	100466738(ASMT)

UMR:	103666293(ASMT)

UAH:	113240809 125281221

UAR:	123802762(ASMT)

ELK:

111157193

LLV:

125092380

MPUF:

101694091(ASMT)

MNP:	132007414(ASMT)

MLK:	131821369(ASMT)

NVS:	122896952(ASMT)

ORO:	101380092(ASMT)

EJU:	114218018(ASMT)

ZCA:	113931316(ASMT)

MLX:	118026672(ASMT)

NSU:	110570022(ASMT)

LWW:	102749404(ASMT)

FCA:	101101365(ASMT)

PYU:	121020204(ASMT) 121024201

PBG:	122477503(ASMT)

PVIV:

125159259(ASMT)

LRUF:

124509606

LGF:	123595193(ASMT)

AJU:

106982046

PTG:	102965330(ASMT)

PPAD:

109256144(ASMT)

PUC:

125931445

PLEZ:

122212678(ASMT)

HHV:	120240552(ASMT)

BTA:	281013(ASMT)

BOM:	102278615(ASMT)

BBUB:

102402187(ASMT)

BBIS:

104996841(ASMT)

CHX:	100861249(ASMT)

OAS:	101114754(ASMT)

BTAX:

128069818(ASMT)

CSUM:

138071282(ASMT)

ODA:	120882418(ASMT)

CCAD:

122434360(ASMT)

MREE:

136153823(ASMT)

OVR:	110146801(ASMT)

MBEZ:

129535155(ASMT)

SSC:

110258194

CFR:	102511012(ASMT)

CBAI:

105079530(ASMT)

CDK:	105103096(ASMT)

VPC:	102538364(ASMT)

BACU:

103008325(ASMT)

BMUS:

118889129(ASMT)

LVE:	103086659(ASMT)

OOR:	101269606(ASMT)

LALB:

132513281(ASMT)

DLE:	111168289(ASMT)

PCAD:

102992951(ASMT)

PSIU:

116747745(ASMT)

NASI:

112415229(ASMT)

ECB:	100146729(ASMT)

EAI:	106821899(ASMT)

MYB:	102248110(ASMT)

MYD:	102766854(ASMT)

MMYO:

118657291(ASMT)

MDT:	132223774(ASMT)

MYUM:

139000524(ASMT)

EFUS:

129150051(ASMT)

MNA:	107542463(ASMT)

DRO:	112313231(ASMT)

SHON:

118974337(ASMT)

AJM:	119045533(ASMT)

PDIC:

114489900(ASMT)

PHAS:

123830129(ASMT)

MMF:	118635966(ASMT)

PPAM:

129079761(ASMT)

HAI:	109375564(ASMT)

RFQ:	117025862(ASMT)

PALE:

102895851(ASMT)

PGIG:

120619045(ASMT)

PVP:	105309071(ASMT)

RAY:	107509923(ASMT) 107510818

TOD:	119246796(ASMT)

SARA:

101542906(ASMT)

SFUM:

130018941(ASMT)

SETR:

126000584(ASMT)

LAV:	100656176(ASMT)

TMU:

101351625

MDO:	100010602(ASMT)

GAS:	123239704(ASMT)

SHR:	100931838(ASMT)

AFZ:

127553690

PCW:	110212828(ASMT)

TVP:	118840246(ASMT)

PBRV:

138149691(ASMT)

TACU:

119937811(ASMT)

GGA:	396286(ASMT)

PCOC:

116230784(ASMT)

MGP:

100547251

CJO:	107305906(ASMT)

TPAI:

128071719(ASMT)

LMUT:

125688412(ASMT)

NMEL:

110405835(ASMT)

ACYG:

106035745(ASMT)

CATA:

118245767(ASMT)

AFUL:

116502250(ASMT)

TGU:	100223806(ASMT)

LSR:	110479371(ASMT)

SCAN:

103812316(ASMT)

PMOA:

120510174(ASMT)

OTC:	121345337(ASMT)

PRUF:

121354077 121354122(ASMT)

ATRC:

139604145(ASMT)

GFR:	102034059(ASMT)

FAB:	101816146(ASMT)

OMA:	130252078(ASMT)

PHI:	102106159(ASMT)

PMAJ:

107211015(ASMT)

CCAE:

111945698(ASMT)

CCW:	104686012(ASMT)

CBRC:

103611766(ASMT)

ACOE:

138106447(ASMT)

ETL:	114067000(ASMT)

ZAB:	102068772(ASMT)

ZLE:	135449418(ASMT)

ACHL:

103807790(ASMT)

SVG:	106862585(ASMT)

MMEA:

130577912(ASMT)

HRT:	120749052(ASMT)

SATI:

136357892(ASMT)

CCIC:

134057954(ASMT)

FPG:	101921940(ASMT)

FCH:	102059795(ASMT)

CCRI:

104154486(ASMT)

NNT:	104399038(ASMT)

SHAB:

115604005(ASMT)

ACUN:

113481640(ASMT)

TALA:

104365399(ASMT)

ACHC:

115334543(ASMT)

HALD:

104325372(ASMT)

HLE:	104839869(ASMT)

AGEN:

126053045

HHAR:

128135116

GCL:

127024923

LDI:	104342081(ASMT)

MNB:	103780791(ASMT)

DPUB:

104302145(ASMT)

PPUS:

135175617(ASMT)

AVIT:

104276945(ASMT)

BRHI:

104497662(ASMT)

EGZ:	104125159(ASMT)

NNI:	104009836(ASMT)

PCRI:

104032563(ASMT)

PCAO:

104053078(ASMT)

PADL:

103923027(ASMT)

AFOR:

103900642(ASMT)

FGA:	104069105(ASMT)

GSTE:

104250290(ASMT)

CLV:	102093193(ASMT)

MUI:	104541176(ASMT)

PGUU:

104471253(ASMT)

PLET:

104622691(ASMT)

EHS:	104517355(ASMT)

CMAC:

104486309(ASMT)

CUCA:

104063724(ASMT)

TEO:	104373904(ASMT)

BREG:

104635287(ASMT)

OHA:	104326404(ASMT)

ACAR:

104529150(ASMT)

CPEA:

104391828(ASMT)

CVF:	104290351(ASMT)

RTD:	128911416(ASMT)

CRID:

134522572(ASMT)

AAM:	106490940(ASMT)

AROW:

112968865(ASMT)

NPD:	112944022(ASMT)

TGT:	104570661(ASMT)

DNE:

112996763

SCAM:

104138696(ASMT)

ASN:	102386765(ASMT)

AMJ:	102575782(ASMT)

CPOO:

109306007(ASMT)

GGN:	109302482(ASMT)

PSS:	102457160(ASMT) 102457574

CMY:	102941645 102941873

CCAY:

125640798 125640803

DCC:	119844621(ASMT)

CPIC:

101936567(ASMT) 101938338

CABI:

116816321 116816338

MRV:	120383012 120395792 120395794 120395795

ACS:	100553393 100554348(asmt) 100557477 100557672 100561592 100562136 100562579 100562776 100567799 100567994 103277504 103279712

ASAO:

132766454 132766455 132769980 132769981 132769982 132769983 132769984 132771638(ASMT)

PVT:	110070785 110070786 110075585 110085416 110085441 110085442 110085443 110090148 110090150

SUND:

121924699 121924700 121924701 121924702 121925830 121925832 121925834 121926228 121926262 121926614 121926871(ASMT)

PBI:	103059937(ASMT)

PMUR:

107286536 107286538 107294461

CTIG:

120313672 120313676 120313678 120313679

TSR:	106540010 106549727 106554057(ASMT)

PGUT:

117656671 117658084 117658471 117659424 117659969 117660334 117666934 117673715 117673798(ASMT) 117673816

APRI:

131199692 131199693 131199695 131199723 131199962 131199963 131199964 131200088 131200125(ASMT)

PTEX:

113440784 113440785 113440786 113440787 113440842 113440843 113440845(ASMT) 113440846

NSS:	113411578 113411579 113411580 113411729 113411743(ASMT)

VKO:	123025348 123033223(ASMT)

PMUA:

114595348(ASMT) 114595351 114595352 114595353 114596398 114596399

PRAF:

128411790 128411791 128411792 128412402 128413244(ASMT)

ZVI:	118085464(ASMT) 118085691 118085693 118085694 118085697 118085698 118085744

HCG:	128350417 128351472(ASMT)

GJA:	107120387(ASMT)

STOW:

125431336(ASMT)

EMC:	129326071 129326177 129326459 129326477 129326550(ASMT)

XLA:	108709071(asmt.S)

XTR:	496888(asmt)

NPR:	108793182(ASMT)

RTEM:

120927478(ASMT) 120927479

BBUF:

120993281 120993678 120994863 120994864 120994865 120994867

BGAR:

122931737 122932660 122932695 122932900 122933182 122935343 122935721

PWL:	138249167(ASMT) 138249169 138250333 138250335

MUO:	115468122 115468123

GSH:	117362958(ASMT)

DRE:	100141344(asmt) 568256(asmt2)

SRX:	107711955 107721495 107749230(asmt)

SANH:

107654826 107668509 107697797(asmt)

SGH:	107566579(asmt) 107590930

CCAR:

109105218(asmt) 109108087(asmt2)

CAUA:

113109204(asmt) 113117525 113117572

CGIB:

127964935 127976092

PTET:

122333026(asmt) 122361757(asmt2)

LROH:

127170535(asmt) 127180181(asmt2)

OMC:	131522811(asmt2) 131547291(asmt)

PPRM:

120487322(asmt2)

RKG:	130073466(asmt2) 130105369(asmt)

MAMB:

125269153(asmt2) 125269539(asmt)

CIDE:

127499151 127519140

CERY:

137006635(asmt2) 137036026(asmt)

MASI:

127411555 127448275

TROS:

130555408(asmt) 130560378(asmt2)

TDW:	130427303(asmt) 130436585(asmt2)

MANU:

129417127(asmt2) 129451554(asmt)

PDAB:

135733653(asmt) 135777936(asmt2)

IPU:	108266217(asmt) 108270049(asmt2)

IFU:	128609318(asmt) 128612855(asmt2)

PHYP:

113524340(asmt) 113545123

SMEO:

124379824(asmt)

TFD:	113640490(asmt2) 113642110(asmt)

TVC:	132850570(asmt) 132852046(asmt2)

CGAR:

128523974(asmt) 128535295(asmt2)

NGRA:

132891469(asmt) 132894660(asmt2)

TRN:	134324258(asmt) 134325201(asmt2)

AMEX:

103034755(asmt2) 103044675(asmt)

CMAO:

118809593(asmt) 118823888(asmt2)

EEE:	113586732(asmt)

CHAR:

105898096(asmt) 122131781(asmt2)

SPIL:

134067314(asmt2) 134077822(asmt)

TRU:	101072678(asmt) 101079954

TFS:	130513144(asmt2) 130525867(asmt)

TNG:	GSTEN00023328G001 GSTEN00030451G001

LCO:	104923845(asmt) 104937665

NCC:	104942862(asmt)

TBEN:

117480060(asmt2) 117485872(asmt)

CGOB:

115026565(asmt) 115027136

PGEO:

117467071(asmt) 117467670(asmt2)

GACU:

117558940(asmt2) 117560131(asmt)

EMAC:

134867526(asmt) 134881548(asmt2)

ELY:	117251693(asmt) 117267285(asmt2)

EFO:	125899464(asmt) 125900651(asmt2)

PLEP:

121949552(asmt) 121953800(asmt2) 121963288

SLUC:

116036795(asmt2) 116037745(asmt)

ECRA:

117936141(asmt2) 117953240(asmt)

ESP:	116695950 116697565(asmt)

PFLV:

114546790 114564545(asmt)

GAT:	120833317(asmt2) 120833566(asmt)

PPUG:

119227820(asmt2) 119228336(asmt)

AFB:	129103815(asmt2) 129105003(asmt)

CLUM:

117750757(asmt) 117751204(asmt2)

PSWI:

130208809(asmt)

CANA:

137783137(asmt) 137802151(asmt2)

CVE:	137877897(asmt2) 137890221(asmt)

MSAM:

119904581(asmt) 119910192(asmt2)

SCHU:

122861388(asmt2) 122886038(asmt)

CUD:	121522973(asmt) 121526411(asmt2)

SPUL:

138591383(asmt2) 138592768(asmt)

LMIX:

132987257(asmt) 132993332(asmt2)

ALAT:

119025887(asmt) 119034306(asmt2)

ASTR:

137605072(asmt) 137611098(asmt2)

MZE:	101473716 101482331(asmt)

ONL:	100692897 100697334(asmt)

OAU:	116311951(asmt) 116329033(asmt2)

OLA:	101155734 101166758(asmt)

OML:	112148334(asmt2) 112155348(asmt)

CSAI:

133446478(asmt) 133462244(asmt2)

XMA:	102225007(asmt) 102236297

XCO:	114134515 114147679(asmt)

XHE:	116709187 116722617(asmt)

PRET:

103461453(asmt)

PFOR:

103129115 103141459(asmt) 103149431

PLAI:

106940144 106949064(asmt) 106952479

PMEI:

106918884(asmt) 106921139 106922542

GAF:	122839351(asmt) 122846142(asmt2)

PPRL:

129361268(asmt) 129377283(asmt2)

CVG:	107087107 107104193(asmt)

CTUL:

119775138(asmt) 119796203(asmt2)

GMU:	124856065(asmt2) 124871029(asmt)

NFU:	107390146(asmt) 107391898

KMR:	108240421(asmt) 108249919(asmt2)

ALIM:

106519738(asmt) 106519950

NWH:	119419074(asmt) 119427098(asmt2)

AOCE:

111584885(asmt) 111585950(asmt2)

EJA:	138200745(asmt) 138205188(asmt2)

BFRE:

138620854(asmt) 138634477(asmt2)

MCEP:

125017288(asmT) 125023759(asmt2)

CSEM:

103392244(asmt)

POV:	109631129(asmt) 109647786 109647889

SSEN:

122765204(asmt)

SSOE:

131454088(asmt)

HHIP:

117755464(asmt) 117756740(asmt2)

HSP:	118115901(asmt2) 118119671(asmt)

PPLT:

128450818(asmt2) 128456226(asmt)

SMAU:

118286016(asmt2) 118320526(asmt)

LCF:	108892755 108902203(asmt2)

SDU:	111218208(asmt) 111225582

SLAL:

111659875 111662718(asmt)

XGL:	120795101(asmt2) 120801723(asmt)

HCQ:	109521119 109531283(asmt)

SSCV:

125973678(asmt) 125980628(asmt2)

SBIA:

133512419(asmt) 133513087(asmt2)

PEE:	133410747(asmt) 133412521

PTAO:

133486847(asmt) 133488324(asmt2)

BPEC:

110156077 110159972

MALB:

109962406 109964371(asmt)

BSPL:

114847552(asmt) 114848561(asmt2)

SJO:	128367464(asmt) 128375667(asmt2)

SSCO:

133993261(asmt) 134001046(asmt2)

GMH:	115533319(asmt)

SASA:

106582195 106586510(asmt) 106611414 106611424

STRU:

115161042(asmt) 115161806

OTW:	112224519(asmt2) 112239807

OMY:	110502086 110506012(asmt2) 110520357

OGO:	124044057(asmt) 124045376(asmt2)

ONE:	115111702(asmt) 115121856

OKI:	109880781 109902910(asmt)

OKE:

118366840

OMM:	135521140 135525460(asmt2)

OCLA:

139383383 139406087

SALP:

111978003(asmt) 112072454

SNH:	120036611(asmt2) 120058059 120063973

CCLU:

121536310 121555335(asmt2)

ELS:	105015875 105016360(asmt)

SFM:	108920780 108929286(asmt)

PKI:	111844195 111846849(asmt)

AANG:

118214462(asmt)

AROT:

135241054(asmt)

CCOG:

133116538(asmt)

LOC:	102683240 102688117(asmt)

PSPA:

121320676 121325361(asmt2)

ARUT:

117406496(asmt) 117420733(asmt2)

PSEX:

120522848(asmt) 120527831(asmt2)

LCM:	102347098(ASMT)

CMK:

103177093

RTP:	109913070(asmt)

CPLA:

122550919(asmt)

HOC:	132816876(asmt)

LERI:

129716262 129716283

PMRN:

116942897(ASMT) 116951550

LRJ:	133340963 133342924

BFO:	118406542 118407243

BBEL:

109477119

SKO:	100366472 100376491 102802951

PFLL:

139118911 139130871 139134087 139137110 139137466 139137468 139137470

HRO:	HELRODRAFT_175003 HELRODRAFT_192339

LGI:	LOTGIDRAFT_173251

PVUL:

PCAN:

GAE:

HRF:

CRG:

CVN:

MYI:

PMAX:

OBI:

OSN:

LJP:

NVE:	5498266 5506515 5506520 5514889 5519567 5520388

EPA:	110231916 110249440

ATEN:

116291505 116307473

MFOO:

138000978

DGT:	114520633 114533355 114533363

XEN:	124453238 124455459 124455460 124455637 124455638 124455640

» show all

Reference

PMID:22775292

Authors

Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemiere N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T

Title

Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.

Journal

J Pineal Res 54:46-57 (2013)
DOI:10.1111/j.1600-079X.2012.01020.x

Sequence

[hsa:438]

LinkDB

DBGET integrated database retrieval system