KEGG ORTHOLOGY: K00669

ORTHOLOGY: K00669

Entry

K00669                      KO

Symbol

AANAT

Name

arylalkylamine N-acetyltransferase [EC:2.3.1.87]

Pathway

map00380

Tryptophan metabolism

map01100

Metabolic pathways

Module

M00037

Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin

Reaction

R02911

acetyl-CoA:aralkylamine N-acetyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K00669  AANAT; arylalkylamine N-acetyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.87  aralkylamine N-acetyltransferase
     K00669  AANAT; arylalkylamine N-acetyltransferase

Other DBs

GO:

0004059

Genes

HSA:

15(AANAT)

PTR:	503504(AANAT)

PPS:	100977321(AANAT)

GGO:	101129527(AANAT)

PON:	100433977(AANAT)

PPYG:

129016664(AANAT)

NLE:	100600128(AANAT)

HMH:	116484181(AANAT)

SSYN:

129462293(AANAT)

MCC:	706924(AANAT)

MCF:	102127968(AANAT)

MTHB:

126939239

MNI:	105469202(AANAT)

CSAB:

103242991(AANAT)

CATY:

105577688(AANAT)

PANU:

101021111(AANAT)

TGE:	112610080(AANAT)

MLEU:

105542397(AANAT)

RRO:	104681272(AANAT)

RBB:	108537333(AANAT)

TFN:	117066724(AANAT)

PTEH:

111542384(AANAT)

CANG:

105517583(AANAT)

CJC:	100406947(AANAT)

SBQ:	101027986(AANAT)

CIMI:

108309467(AANAT)

ANAN:

105718303(AANAT)

CSYR:

103250644(AANAT)

MMUR:

105878976(AANAT)

LCAT:

123620487(AANAT)

PCOQ:

105824783(AANAT)

OGA:	100966018(AANAT)

MMU:	11298(Aanat)

MCAL:

110304584(Aanat)

MPAH:

110332666(Aanat)

RNO:	25120(Aanat)

MCOC:

116077976(Aanat)

ANU:	117711177(Aanat)

ASYL:

127695442(Aanat)

MUN:	110542260(Aanat)

CGE:	100755392(Aanat)

MAUA:

101834092(Aanat)

PROB:

127221552(Aanat)

PLEU:

114707082(Aanat)

MORG:

121436288(Aanat)

MFOT:

126500454

AAMP:

119813655(Aanat)

NGI:	103732690(Aanat)

HGL:	101713893(Aanat)

CPOC:

100724241(Aanat)

CCAN:

109685598(Aanat)

DORD:

106003068(Aanat)

DSP:	122094967(Aanat)

PLOP:

125365967(Aanat)

NCAR:

124981032

MMMA:

107157857(Aanat)

ITI:	101969498(Aanat)

OCU:

100357535

OPI:	101525294(AANAT)

TUP:	102470373(AANAT)

GVR:	103605509(AANAT)

CFA:	483331(AANAT)

CLUD:

112672836(AANAT)

VVP:	112920613(AANAT)

VLG:	121473674(AANAT)

NPO:	129508128(AANAT)

AML:	100482847(AANAT)

UMR:	103665763(AANAT)

UAH:	113244682(AANAT)

UAR:	123802940(AANAT)

ELK:

111160461

LLV:

125087596

MPUF:

101672101(AANAT)

MNP:	132003491(AANAT)

MLK:	131817002(AANAT)

NVS:	122907529(AANAT)

ORO:	101375231(AANAT)

EJU:	114216050(AANAT)

ZCA:	113939291(AANAT)

MLX:	118024237(AANAT)

NSU:	110572512(AANAT)

LWW:	102750097(AANAT)

FCA:	101098178(AANAT)

PYU:	121017956(AANAT)

PCOO:

112864704(AANAT)

PBG:	122486123(AANAT)

PVIV:

125151984(AANAT)

LRUF:

124513228

LGF:	123604051(AANAT)

AJU:

113596985

PTG:	102953543(AANAT)

PPAD:

109276895(AANAT)

PUC:

125926331

HHV:	120228269(AANAT)

BTA:	112442710 281583(AANAT)

BOM:	102279792 138992005(AANAT)

BIU:	109573499 109573505

BBUB:

102401346 102412521(AANAT)

BBIS:

105000375

CHX:	100860947(AANAT) 102190991(AANAT)

OAS:	105601853 443531(AANAT)

BTAX:

128065506 128065508

CSUM:

138083693 138084025

ODA:	120859233 120859234 120866544(AANAT)

CCAD:

122424699 122442155

MREE:

136149552 136149743

OVR:	110152065 110152081

MBEZ:

129544688 129544691

SSC:	100518330 110255264

CFR:	102522698 116669211 116669239

CBAI:

105065622(AANAT)

CDK:	105092185(AANAT)

VPC:	102540360(AANAT)

BACU:

103011665(AANAT)

BMUS:

118887283(AANAT)

LVE:	103071739(AANAT)

OOR:	101286550(AANAT)

LALB:

132511943(AANAT)

DLE:	111182937(AANAT)

PCAD:

102993089(AANAT)

PSIU:

116746215(AANAT)

NASI:

112410182(AANAT)

ECB:	100058770(AANAT)

EPZ:	103565530(AANAT)

EAI:	106830333(AANAT)

MYB:	102257691(AANAT)

MMYO:

118672357(AANAT)

MDT:	132217884(AANAT)

MYUM:

138994486(AANAT)

PKL:	118704556(AANAT)

EFUS:

103298393(AANAT)

MNA:	107536593(AANAT)

DRO:	112298834(AANAT)

SHON:

119000101(AANAT)

AJM:	119058577(AANAT)

PDIC:

114504159(AANAT)

PHAS:

123817386(AANAT)

MMF:	118634540(AANAT)

HAI:	109383638(AANAT)

RFQ:	117013054(AANAT)

PALE:

102898841(AANAT)

PGIG:

120599975(AANAT)

PVP:	105293433(AANAT)

RAY:	107510038(AANAT)

MJV:	108398665(AANAT)

TOD:	119231650(AANAT)

SARA:

101553717(AANAT)

SFUM:

130024663(AANAT)

SETR:

126001335(AANAT)

LAV:	100667906(AANAT)

ETF:	101656083(AANAT)

MDO:	100026619(AANAT)

GAS:	123247143(AANAT)

SHR:	100924836(AANAT)

AFZ:

127560436

PCW:	110219333(AANAT)

TVP:	118849055(AANAT)

PBRV:

138152477(AANAT)

OAA:	100076568(AANAT)

TACU:

119921970(AANAT)

GGA:	396066(AANAT)

PCOC:

116232615(AANAT)

MGP:	100549848(AANAT)

CJO:	107322266(AANAT)

TPAI:

128083092(AANAT)

LMUT:

125702058(AANAT)

NMEL:

110407363(AANAT)

APLA:

101798734(AANAT)

ACYG:

106034630(AANAT)

CATA:

118260378(AANAT)

AFUL:

116496655(AANAT)

TGU:	100228432(AANAT)

LSR:	110476573(AANAT)

SCAN:

103820004(AANAT)

PMOA:

120505532(AANAT)

OTC:	121338384(AANAT)

PRUF:

121363880(AANAT)

ATRC:

139602629(AANAT)

GFR:	102044523(AANAT)

FAB:	101817679(AANAT)

OMA:	130260449(AANAT)

PHI:	102107121(AANAT)

PMAJ:

107212354(AANAT)

CCAE:

111937273(AANAT)

CCW:	104694394(AANAT)

CBRC:

103621763(AANAT)

ACOE:

138120248(AANAT)

ETL:	114058599(AANAT)

ZLE:	135455383(AANAT)

ACHL:

103798751(AANAT)

SVG:	106861012(AANAT)

MMEA:

130581058(AANAT)

HRT:	120761025(AANAT)

SATI:

136369300(AANAT)

CCIC:

134052141(AANAT)

FPG:	101917150(AANAT)

FCH:	102045840(AANAT)

CCRI:

104160913(AANAT)

SHAB:

115616703(AANAT)

ACUN:

113486749(AANAT)

TALA:

116964028(AANAT)

ACHC:

115340961(AANAT)

HLE:	104839203(AANAT)

AGEN:

126044047

HHAR:

128151341(AANAT)

GCL:

127024165

LDI:	104351342(AANAT)

DPUB:

104298011(AANAT)

PPUS:

135179308(AANAT)

AVIT:

104270956(AANAT)

BRHI:

104495970(AANAT)

EGZ:	104125379(AANAT)

NNI:	104022838(AANAT)

PCRI:

104034687(AANAT)

PADL:

103921009(AANAT)

AFOR:

103899024(AANAT)

CLV:	102097087(AANAT)

MUI:	104540984(AANAT)

PGUU:

104469399(AANAT)

CUCA:

104068672(AANAT)

TEO:	104376464(AANAT)

ACAR:

104517843(AANAT)

CPEA:

104387780(AANAT)

CVF:	104284129(AANAT)

RTD:	128918125(AANAT)

CRID:

134523426(AANAT)

AAM:	106485386(AANAT)

AROW:

112977768(AANAT)

NPD:	112957705(AANAT)

TGT:	104577592(AANAT)

DNE:	112985340(AANAT)

ASN:	102385650(AANAT)

AMJ:	102558329(AANAT)

CPOO:

109315105(AANAT)

GGN:	109286971(AANAT)

PSS:	102454343(AANAT)

CMY:	102939980(AANAT)

CCAY:

125621375(AANAT)

DCC:	119843400(AANAT)

CPIC:

101949766(AANAT)

TST:	117887303(AANAT)

CABI:

116832292(AANAT)

MRV:	120383350(AANAT)

ACS:	100560631(aanat)

ASAO:

132768582(AANAT)

PVT:	110085911(AANAT)

SUND:

121922887(AANAT)

PBI:	103059427(AANAT)

PMUR:

107290061(AANAT)

CTIG:

120301161(AANAT)

TSR:	106554544(AANAT)

PGUT:

117660475(AANAT)

APRI:

131191119(AANAT)

PTEX:

113437174(AANAT)

NSS:	113412100(AANAT)

VKO:	123035638(AANAT)

PMUA:

114590653(AANAT)

PRAF:

128407531(AANAT)

ZVI:	118079864(AANAT)

HCG:	128343243(AANAT)

GJA:	107121146(AANAT)

STOW:

125428195(AANAT)

EMC:	129328344(AANAT)

XLA:	100335045(aanat.S) 100335046(aanat.L)

XTR:	100497589(aanat)

NPR:	108796857(AANAT)

RTEM:

120918502(AANAT)

BBUF:

121005313(AANAT)

BGAR:

122942559(AANAT)

PWL:	138246048(AANAT)

MUO:	115472837(AANAT)

GSH:	117367353(AANAT)

DRE:	30685(aanat2) 393677(aanat1)

SRX:	107711187 107715487(aanat) 107742556 107754039

SANH:

107670449 107672440 107702983(aanat)

SGH:	107561337(aanat) 107588006 107596820

CCAR:

109056260 109056933 109059207(aanat1)

CAUA:

113042439 113050725(aanat) 113082008 113095415

CGIB:

127952843 127953320 128016227

PTET:

122339818(aanat2) 122347060(aanat1)

LROH:

127162811(aanat2) 127167246(aanat1)

OMC:	131537300(aanat2) 131542210(aanat1)

PPRM:

120466727(aanat1) 120489294(aanat2)

RKG:	130081164(aanat1) 130086874(aanat2)

MAMB:

125268979(aanat2) 125273287(aanat1)

CIDE:

127509052 127513808

CERY:

137010876(aanat1) 137017848(aanat2)

MASI:

127449031 127449977 127452121

TROS:

130556448(aanat1) 130561671(aanat2)

TDW:	130424783(aanat1) 130425558(aanat2)

MANU:

129431151(aanat2)

PDAB:

135732711(aanat2)

IPU:	108257103(aanat2) 108273103(aanat1)

IFU:	128600255(aanat2) 128616144(aanat1)

PHYP:

113536007 113538260(aanat)

SMEO:

124376137(aanat2) 124383978(aanat1)

TFD:	113634427(aanat1) 113640464(aanat2)

TVC:	132844830(aanat1) 132864220(aanat2)

CGAR:

128518739(aanat2) 128526815(aanat1)

NGRA:

132884318(aanat1) 132900095(aanat2)

TRN:	134301211(aanat2) 134316555(aanat1)

AMEX:

103029239(aanat2) 103031094(aanat1)

CMAO:

118805779(aanat2) 118807506(aanat1)

EEE:	113571837 113583276

CHAR:

105898567 105900207(aanat1) 105907855(aanat2) 116222096

SPIL:

134075898 134076071(aanat2) 134079544(aanat1)

TRU:	101065059 101069944(aanat) 101071652

TFS:	130515251(aanat2) 130515355 130527336(aanat1)

TNG:	GSTEN00007250G001 GSTEN00010408G001 GSTEN00032513G001

LCO:	104918698 104932979(aanat) 104938975

NCC:	104953103 104955756

TBEN:

117480002 117482324(aanat1) 117493183(aanat2)

CGOB:

115009663(aanat) 115011759 115012355

PGEO:

117447000(aanat1) 117451480(aanat2)

GACU:

117537866(aanat1) 117548728(aanat2)

EMAC:

134864399(aanat1) 134878286(aanat2) 134878314

ELY:	117254966(aanat1) 117268622(aanat2) 117268670

EFO:	125879145 125879210(aanat2) 125884970(aanat1)

PLEP:

121939806 121941854(aanat1) 121956108(aanat2)

SLUC:

116042642(aanat1) 116059525(aanat2) 116065468

ECRA:

117957840 117958329(aanat2) 117960910(aanat1)

ESP:	116700109(aanat) 116703094 116703551

PFLV:

114569609 114569801 114569809

GAT:	120825377(aanat1) 120827539 120827719(aanat2)

PPUG:

119218418(aanat1) 119220452 119220746(aanat2)

AFB:	129095288(aanat1) 129098669 129098679(aanat2)

CLUM:

117734499(aanat2) 117735083 117738296(aanat1)

PSWI:

130188900 130189293(aanat2) 130189953(aanat1)

CANA:

137786432 137786535(aanat2) 137795057(aanat1)

CVE:	137878326 137884959(aanat1) 137885642(aanat2)

MSAM:

119883952 119891562(aanat2) 119899313(aanat1)

SCHU:

122868535(aanat2) 122869406 122873583(aanat1)

CUD:	121503573 121503576(aanat2) 121508637(aanat1)

SPUL:

138594738(aanat1) 138602828(aanat2) 138604190

LMIX:

132954031(aanat2) 132954713 132993107(aanat1)

ALAT:

119014348(aanat2) 119014811 119026957(aanat1)

ASTR:

137600320(aanat1) 137609732(aanat2) 137610341

MZE:	101470946 101472579(aanat) 101479147

ONL:	100689833 100690180 100706826(aanat)

OAU:	116310830(aanat1) 116318401(aanat2) 116327149

OLA:	100049467(aanat) 100049488(aanat2) 100049507(aanat1b)

OML:	112146110 112146445(aanat2) 112157294(aanat1)

CSAI:

133421525 133422430(aanat2) 133449813 133450473

XMA:	102226079 102233098 102235970(aanat)

XCO:	114145405 114159590 114160189

XHE:	116720846 116735180 116735883

PRET:

103468403 103468705 103469693

PFOR:

103143668 103143768 103143770 103153197

PLAI:

106937025 106942159 106950860 106964066

PMEI:

106911672 106918968 106934031 106934060

GAF:	122821519(aanat2) 122822124 122830249(aanat1)

PPRL:

129352508(aanat2) 129363416(aanat1)

CVG:	107083117 107100582(aanat) 107104616

CTUL:

119771323(aanat1) 119785324(aanat2) 119797287

GMU:	124862532 124863331 124864628 124865019 124868481(aanat1)

NFU:	107376253 107378383 107382246

KMR:	108236158 108243703(aanat2) 108248779(aanat1)

ALIM:

106518761 106523853 106528835

NWH:	119421791(aanat2) 119422146 119423194(aanat1)

AOCE:

111564217(aanat1) 111567914 111574835(aanat2)

EJA:	138197682 138197835(aanat2) 138209075(aanat1)

BFRE:

138620151(aanat1) 138622350 138630912(aanat2)

MCEP:

124997602(aanat2) 124997799 125003790(aanat1)

CSEM:

103383775 103392596 103393389

POV:	109627400 109634267 109644751

SSEN:

122763909(aanat2) 122770985(aanat1)

SSOE:

131467396(aanat1) 131475376 131475532(aanat2)

HHIP:

117763112(aanat1) 117766279 117766473(aanat2)

HSP:	118119218(aanat1) 118123053(aanat2) 118123157

PPLT:

128437020(aanat1) 128458762 128458796(aanat2)

SMAU:

118289025 118289414(aanat2) 118312186(aanat1)

LCF:	108875852(aanat1) 108879348 108898703 108902966

SDU:	111217515 111236294(aanat) 111238089

SLAL:

111659761 111660619 111673755

XGL:	120787793(aanat2) 120787961(aanat1)

HCQ:	109513811 109516440 109519790(aanat)

SSCV:

125969559(aanat1) 125983907(aanat2) 125984168

SBIA:

133505704(aanat1) 133514514 133514806(aanat2)

PEE:	133403527(aanat1) 133414872(aanat2) 133414889

PTAO:

133466295 133466440(aanat2) 133477514(aanat1)

BPEC:

110166218(aanat) 110170029 110172214

MALB:

109966005 109966258(aanat) 109974664

BSPL:

114855511(aanat1) 114860298 114860556(aanat2)

SJO:	128371938(aanat1) 128378755(aanat2) 128378769

SSCO:

133993481(aanat1) 133999602(aanat2) 133999630

GMH:	115537377 115560896

SASA:

106588571(aanat) 106601142 106601410 106607000 106607367

STRU:

115170616 115170622 115178176 115201927 115203761

OTW:	112230148(aanat1) 112234611 112246025 112258719 112259441

OMY:	100135782 100135881(aanat-2) 110487522(aanat1) 110538456 110538513

OGO:	123999575 124000370 124015435 124016078(aanat1) 124016278

ONE:	115103555 115103628 115103642 115109882 115110646

OKI:	109865984 109892009 109892256 109897608 109897627

OKE:	118364760 118364952 118365364 118375063(aanat2) 118384683

OMM:	135520575 135553735 135554870 135554958 135554988

OCLA:

139421242 139422279 139423955 139423997 139424657

SALP:

111955129 111980399 111981627

SNH:	120032934 120034461 120034465 120044556 120044615

CCLU:

121550932 121551145 121570396 121570428

ELS:	105013156 105013380 105021627(aanat)

SFM:	108935849 108939955(aanat)

PKI:	111843224 111848397(aanat)

AANG:

118219646(aanat1) 118221224(aanat2)

AROT:

135248326(aanat2) 135249054(aanat1)

CCOG:

133122095(aanat1) 133122339(aanat2)

LOC:	102683533(aanat) 102686229

PSPA:

121295719 121296561(aanat1) 121330940(aanat2)

ARUT:

117418367 117423197(aanat1) 117424323 117431354

PSEX:

120517232(aanat1) 120542384(aanat2)

LCM:	102349438(AANAT)

CMK:	103188407(aanat2)

RTP:

CPLA:

HOC:

LERI:

LRJ:	133339092(AANAT)

DME:	Dmel_CG3318(speck)

DER:

6547970

DSE:

6613030

DSI:	Dsimw501_GD15464(Dsim_Dat)

DYA:	Dyak_GE14383

DAN:

DSR:

DPO:

DPE:

DMN:	108160778 117190948

DWI:

6652169

DGR:

6560444

DMO:	Dmoj_GI20262

DAZ:

108616403

DNV:

108653929

DHE:	111600616 115482737

CCAT:

101459162

BOD:

106618444

BDR:	105225353 125780252

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135963287(speck)

GFS:

119641732

ECOE:

129952127

CLON:

129608762 129612152 129612400 129612611 129612809

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ015282

CPII:

120425442

CNS:	116342447 116350849

BCOO:

119073769

LLL:	129785888 129789764

PPAP:

PFUC:

NPT:

NFB:

NLO:

SOY:

AGRG:

CSET:

AGB:

LDC:	111505099 111505728 111509399

DVV:

114331350

APLN:

108743952

PPYR:

116169540 116169784 116169786

OTU:	111427395 111427414 111427421

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

LSIN:

SLIU:

OFU:

CCRN:

ACOO:

126841165 126841166 126841167

HVI:

124357094

MQU:	128987811 128993946

FOC:	113201897 113218248

TPAL:

117643620 117644122 117654200

CSEC:

DMK:

MMER:

RPHI:

Reference

PMID:11313340

Authors

Coon SL, Weller JL, Korf HW, Namboodiri MA, Rollag M, Klein DC

Title

cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation.

Journal

J Biol Chem 276:24097-107 (2001)
DOI:10.1074/jbc.M011298200

Sequence

[hsa:15]

LinkDB

DBGET integrated database retrieval system