KEGG ORTHOLOGY: K05689

ORTHOLOGY: K05689

Entry

K05689                      KO

Symbol

CDH1, CDHE, CD324

Name

cadherin 1, type 1, E-cadherin

Pathway

map04015

Rap1 signaling pathway

map04371

Apelin signaling pathway

map04390

Hippo signaling pathway

map04514

Cell adhesion molecules

map04520

Adherens junction

map05100

Bacterial invasion of epithelial cells

map05200

Pathways in cancer

map05213

Endometrial cancer

map05216

Thyroid cancer

map05218

Melanoma

map05219

Bladder cancer

map05226

Gastric cancer

Disease

H00018

Gastric cancer

H00025

Penile cancer

H00026

Endometrial cancer

H00027

Ovarian cancer

H00032

Thyroid cancer

H00054

Nasopharyngeal cancer

H02474

Blepharocheilodontic syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
   04390 Hippo signaling pathway
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
   04371 Apelin signaling pathway
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
  09162 Cancer: specific types
   05226 Gastric cancer
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
   05216 Thyroid cancer
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
   05218 Melanoma
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
   05219 Bladder cancer
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
   05213 Endometrial cancer
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
   04090 CD molecules
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Other centrosome associated proteins
    K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
Cell adhesion molecules [BR:ko04515]
Cadherins
  Major cadherins
   K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
CD molecules [BR:ko04090]
Proteins
  K05689  CD324, CDH1; cadherin 1, type 1, E-cadherin (epithelial)

Genes

HSA:

999(CDH1)

PTR:	468009(CDH1)

PPS:	100989112(CDH1)

GGO:	101145191(CDH1)

PON:	100174439(CDH1)

PPYG:

129015676(CDH1)

NLE:	100596627(CDH1)

HMH:	116471429(CDH1)

SSYN:

129492928(CDH1)

MCC:	704387(CDH1)

MCF:	102143513(CDH1)

MTHB:

126944055

MNI:	105491370(CDH1)

CSAB:

103233229(CDH1)

CATY:

105582144(CDH1)

PANU:

101005609(CDH1)

TGE:	112613986(CDH1)

MLEU:

105552371

RRO:	104655589(CDH1)

RBB:	108514542(CDH1)

TFN:	117087958(CDH1)

PTEH:

111541390(CDH1)

CANG:

105504620(CDH1)

CJC:	100398679(CDH1)

SBQ:	101049706(CDH1)

CIMI:

108311694(CDH1)

ANAN:

105706725(CDH1)

CSYR:

103268676

MMUR:

105858954(CDH1)

LCAT:

123625167(CDH1)

PCOQ:

105823410(CDH1)

OGA:

100958318

MMU:	12550(Cdh1)

MCAL:

110300286(Cdh1)

MPAH:

110337432(Cdh1)

RNO:	83502(Cdh1)

MCOC:

116070104(Cdh1)

ANU:	117722998(Cdh1)

ASYL:

127671435(Cdh1)

MUN:	110545977(Cdh1)

CGE:	100758185(Cdh1)

MAUA:

101836544(Cdh1)

PROB:

127234412(Cdh1)

PLEU:

114683440

MORG:

121447012(Cdh1)

MFOT:

126502689

AAMP:

119802116(Cdh1)

NGI:	103734864(Cdh1)

HGL:	101719565(Cdh1)

CPOC:

100726210(Cdh1)

CCAN:

109693763(Cdh1)

DORD:

105982885(Cdh1)

DSP:	122126091(Cdh1)

PLOP:

125358251(Cdh1)

NCAR:

124966611

MMMA:

107151067(Cdh1)

ITI:	101968091(Cdh1)

OCU:

100356548

OPI:	101529529(CDH1)

TUP:	102499381(CDH1)

GVR:	103585943(CDH1)

CFA:	442858(CDH1) 489647

CLUD:

112646539(CDH1) 112646860

VVP:	112924654 112929524(CDH1)

VLG:	121500345(CDH1) 121500539

NPO:	129496751(CDH1) 129496858

AML:	100475573(CDH1) 105240970

UMR:	103673623(CDH1) 103673974

UAH:	113252413(CDH1)

UAR:	123776641 123803436(CDH1)

ELK:	111152800 111152817

LLV:	125089117 125089388

MPUF:

101680359 101682346(CDH1)

MNP:	132005529 132005731(CDH1)

MLK:	131818685 131818928(CDH1)

NVS:	122911306(CDH1) 122914642

ORO:	101375608(CDH1)

EJU:	114201853(CDH1)

ZCA:	113935979(CDH1)

MLX:	118023633(CDH1)

NSU:	110593709 110594235(CDH1)

LWW:	102728802(CDH1) 102736035

FCA:	101095391(CDH1)

PYU:	121009705(CDH1)

PCOO:

112857227(CDH1)

PBG:	122495148(CDH1)

PVIV:

125153351(CDH1) 125158859

LRUF:

124510761 124510785

LGF:	123579359(CDH1)

AJU:

106972406

PTG:	102949516(CDH1) 102971532

PPAD:

109270716(CDH1)

PUC:	125916271 125916643

PLEZ:

122207772 122208451(CDH1)

HHV:	120225176(CDH1)

BTA:	282637(CDH1)

BOM:	102284702(CDH1)

BIU:

109572856

BBUB:

102400153(CDH1)

BBIS:

104996661(CDH1)

CHX:	102170451(CDH1)

OAS:	101119747(CDH1)

BTAX:

128063421(CDH1)

CSUM:

138096386(CDH1)

ODA:	120872702(CDH1)

CCAD:

122421517(CDH1)

MREE:

136161108(CDH1)

OVR:	110137150(CDH1)

MBEZ:

129546962(CDH1) 129555178

SSC:	100048953(CDH1)

CFR:

102518832

CBAI:

105074863(CDH1)

CDK:	105088409(CDH1)

VPC:

102539658

BACU:

102999370(CDH1)

BMUS:

118885031(CDH1)

LVE:	103073913(CDH1)

OOR:	101288322(CDH1)

LALB:

132509512(CDH1)

DLE:	111179595(CDH1)

PCAD:

102988252(CDH1)

PSIU:

116743680(CDH1)

NASI:

112392355(CDH1)

ECB:	100066844(CDH1)

EPZ:	103549722(CDH1)

EAI:	106822455(CDH1)

MYB:	102243128(CDH1)

MYD:	102763531 102771627(CDH1)

MMYO:

118674502(CDH1)

MLF:	102430843(CDH1)

MDT:	132217424(CDH1)

MYUM:

138997071(CDH1)

PKL:	118720916(CDH1)

EFUS:

103284615

MNA:	107527895(CDH1)

DRO:	112300798(CDH1)

SHON:

118983812(CDH1)

AJM:	119061846(CDH1)

PDIC:

114488249(CDH1)

PHAS:

123805903(CDH1)

MMF:	118639271(CDH1)

PPAM:

129075248(CDH1)

HAI:	109389333(CDH1)

RFQ:	117034767(CDH1)

PALE:

102886394(CDH1)

PGIG:

120593865(CDH1)

PVP:	105305756(CDH1)

RAY:	107520648(CDH1)

MJV:	108404941(CDH1)

TOD:	119248990(CDH1)

SARA:

101547461(CDH1)

SFUM:

130043718(CDH1)

SETR:

126027347(CDH1)

LAV:	100659456(CDH1)

TMU:

101350182

ETF:	101662126(CDH1)

DNM:	101418309(CDH1)

MDO:	100027800(CDH1)

GAS:	123236751(CDH1)

SHR:	100920258(CDH1)

AFZ:

127547749

PCW:	110210266(CDH1)

TVP:

118841911

PBRV:

138159283(CDH1)

OAA:	100079609(CDH1)

TACU:

119934252

GGA:	415860(CDH1)

PCOC:

116243675 116243717

MGP:

104913062

CJO:	107319443 107319509

LMUT:

125699326(CDH1)

NMEL:

110404211

APLA:

101794572(CDH1)

ACYG:

106046593(CDH1)

CATA:

118257836 118257859(CDH1)

AFUL:

116493989 116494167

TGU:

100232461

LSR:

110468793

SCAN:

103816905(CDH1)

PMOA:

OTC:

PRUF:

ATRC:

GFR:	102040110(CDH1)

FAB:	101805985(CDH1)

OMA:	130257946(CDH1) 130257950

PHI:	102111961 102112140

PMAJ:

107209925(CDH1)

CCAE:

111944815

CCW:

104691942

CBRC:

103620586

ACOE:

138116837(CDH1)

ETL:	114067998(CDH1)

ZAB:	102073774(CDH1)

ZLE:	135452657(CDH1)

SVG:	106861285(CDH1)

HRT:	120757590(CDH1)

SATI:

136366388(CDH1)

CCIC:

134048198(CDH1)

FCH:

102055639

NNT:	104407331(CDH1)

SHAB:

ACUN:

TALA:

ACHC:

HLE:	104839403(CDH1)

AGEN:

126040274

HHAR:

128145790(CDH1)

GCL:

127020987

DPUB:

104303814(CDH1) 104303816

PPUS:

135184171 135184425

AFOR:

103907312(CDH1)

CLV:	110354868(CDH1)

MUI:

104536944

CUCA:

104055001

CPEA:

104398359(CDH1)

RTD:

128908666

AAM:

106487432

AROW:

112975127(CDH1)

NPD:

112947506

TGT:

104571666

DNE:	112994996(CDH1)

SCAM:

104138116

ASN:	102380182(CDH1)

AMJ:	102576711 106737158(CDH1)

CPOO:

109310379(CDH1)

GGN:	109289251(CDH1)

PSS:	102455385 102455630 102455872

CMY:	102948095(CDH1) 102948317(CDH3)

CCAY:

125645307

DCC:

119841373

CPIC:

101946109

CABI:

116819568(CDH1)

MRV:

120384549

ACS:	100558436(cdh1)

ASAO:

132783300

PVT:	110076337(CDH1) 110076338

SUND:

121914482

PBI:	103048275(CDH1)

PMUR:

107283491 107283520

CTIG:

120302502

TSR:

106542216

PGUT:

117671054(CDH1)

APRI:

131184357(CDH1)

PTEX:

113448977(CDH1)

NSS:	113423418(CDH1)

VKO:

123022404

PMUA:

114602086(CDH1) 114602091(CDH3)

PRAF:

128419331(CDH1)

ZVI:	118086674 118086675 118086676

HCG:

128334618

GJA:	107106524 107106525 107106526

STOW:

125443695

EMC:

129344298

XLA:	100337618(cdh1.S) 108714071(cdh1.L) 394290(cdh3.S) 594865(cdh3.L)

XTR:	100485633(cdh3) 779546(cdh1)

NPR:	108787706 108787724

RTEM:

120917994 120917996 120917998 120918000 120922023 120922024

BBUF:

120980563 120980675 120981208(CDH1)

BGAR:

122920361 122920759 122920889

PWL:	138266903 138266996 138267108

MUO:	115470979 115470982(CDH1)

GSH:	117358666(CDH1)

DRE:	114424(cdh1) 567602(cdh31)

SRX:	107716503 107730137 107736454

SANH:

107662865 107663036 107685849 107685862 107698680

SGH:	107561456 107561466 107571929 107574478 107600033 107600334

CCAR:

109050309 109050310 109084527 109104773 109109406

CAUA:

113051299 113106334 113106335 113118000

CGIB:

127961419 127961420 128016583

PTET:

122349536(cdh1) 122349537(cdh31) 122349544

LROH:

127157561 127167674(cdh31)

OMC:	131544940 131544941

PPRM:

120492656(cdh1)

RKG:

130070431

MAMB:

125265839(cdh31)

CIDE:

CERY:

MASI:

TROS:

TDW:	130427937 130428043 130430155

MANU:

129452513 129452519 129452612

PDAB:

135743631 135743864(cdh31) 135743866 135743867

IFU:

128602796

PHYP:

113546740

SMEO:

124379786(cdh31)

TFD:

113634238

TVC:

132838501

CGAR:

128519549(cdh31)

NGRA:

132874961 132875176 132875177

TRN:	134303825 134303826

AMEX:

103023785 111190272 111190278 125790024

CMAO:

118817322 118817323 118817598 118817599

EEE:	113575713(cdh1) 113575719

CHAR:

105892895 105904215 105904217 105906549

SPIL:

134094282 134094406 134095807 134095808

TRU:	101062978 101071407 101074001 105418450

TFS:	130533542(cdh31) 130536803

TNG:	GSTEN00005507G001 GSTEN00005508G001 GSTEN00009998G001 GSTEN00033333G001

LCO:	104918151 104936033

NCC:

104965112

TBEN:

117475857 117475873(cdh31) 117491884

CGOB:

115009383 115020335

PGEO:

117447826 117459821(cdh1)

GACU:

117545777 117550721 117550746

EMAC:

134858893 134876533

ELY:	117248092 117248591 117262549(si:dkey-30c15.12)

EFO:	125888031 125903952

PLEP:

121950180 121954201 121954283

SLUC:

116041154 116047882 116047883

ECRA:

117941851 117960927(cdh31)

ESP:	116676313 116696602

PFLV:

114552230 114552662 114553195 114560085 114572218

GAT:

120820444

PPUG:

119214285 119214287

AFB:	129092024 129107906

CLUM:

117732378 117743986

PSWI:

130194998 130206976(cdh31)

CANA:

137779962(cdh31)

CVE:	137880816(si:dkey-30c15.12) 137885941

MSAM:

119905872 119905873 119917376

SCHU:

122884777

CUD:

121514546

SPUL:

138588314(cdh1) 138612775

LMIX:

132972382(si:dkey-30c15.12) 132975945

ALAT:

119023855 119033129

ASTR:

137594258(si:dkey-30c15.12) 137603941(cdh1)

MZE:	101464797 101470923 101479144 111500340

ONL:	100696485 100697919 100698188 100702590 100703134 100706561 106097891

OAU:	116309954 116311266 116317802 116318273 116333747

OLA:	101169589 101171060 101172313 105353623 105357330 105358576 111948794

OML:	112137331(cdh1) 112137332 112137669 112137670 112139621 112154405

CSAI:

133444312 133463192

XMA:	102227130 102227391 102227779 102232938 102235778 111606709 111606710

XCO:	114137625 114137627 114150042 114152223

XHE:	116712570 116712572 116712573 116712576 116725087

PRET:

103466018 103476546 103476549 103476551 103476553

PFOR:

103133758 103151033 103153121 103153122 103153123 103153125

PLAI:

106939881 106939882 106941825 106942328 106956294

PMEI:

106906182 106908272 106908435 106909547 106909548 106912408

GAF:	122819437 122835500 122842040 122842041 122842043 122842044(si:busm1-71b9.3) 122842045

PPRL:

129354601 129354612 129356873 129356875 129360640(si:dkey-30c15.12) 129374102

CVG:	107088912 107088913 107089230 107092581

CTUL:

119771883 119792671(cdh31) 119792672 119793009(si:dkey-30c15.12)

GMU:	124858983(cdh1) 124858984(si:busm1-71b9.3) 124859614

NFU:	107397122(cdh1)

KMR:	108229976 108243357 108244116 108244126

ALIM:

106513149 106513699

NWH:	119413951 119416034(si:dkey-30c15.12)

AOCE:

111564883 111585729

EJA:	138193684 138205967

BFRE:

138628227 138633386

MCEP:

125014405(si:dkey-30c15.12) 125018796(cdh1) 125018797

CSEM:

103387719

POV:	109624646 109634041

SSEN:

122775887 122781913

SSOE:

131469432 131474147

HHIP:

117762686 117775289 117775290 117775292 117775653

HSP:	118109098 118118848 124851067

PPLT:

128444264 128453345(cdh1) 128453346

SMAU:

118283500 118315912

LCF:	108875147 108895764

SDU:	111228639 111236417

SLAL:

111647048 111653311

XGL:	120793396 120796800(cdh1)

HCQ:

109523134

SSCV:

125978893(cdh1)

SBIA:

133502469 133509393(cdh1)

PEE:	133403135 133409757(cdh1)

PTAO:

133477844 133485382(cdh1)

BPEC:

110166826 110170962 110174808

MALB:

109960058(cdh1)

BSPL:

114842098 114865912 114870416 114870843

SJO:	128372579 128373391 128373392

SSCO:

133992259(si:busm1-71b9.3) 133992260 133992370

GMH:	115539358 115539360 115539361 115544470 115559946

SASA:

106562057 106573965 106573979 106587268(CADH1)

STRU:

115167390 115202968

OTW:	112249103 112263576(cdh31)

OMY:	110489630 110506405 110526291

OGO:	124033841 124033842 124035818

ONE:	115112149 115112150 115113568

OKI:	109874403 109886448 109895465

OKE:	118358657 118393767

OMM:

135504470

OCLA:

139385097 139411380 139411381

SALP:

111969097 111969297 112070103

SNH:	120024733 120046244

CCLU:

121559214 121559224 121559744 121559754

ELS:

105016989

SFM:	108934563 108934571 114911890

PKI:

AANG:

AROT:

CCOG:

LOC:	102683213(cdh1) 102694645

PSPA:

121296306 121325617

ARUT:

117424208 117425027

PSEX:

120534870 120535420

LCM:	102359919 102361385(CDH1) 102364978

CMK:

103175998

RTP:

109937057

CPLA:

122558323(cdh31)

HOC:	132823917(cdh31)

LERI:

129705440(cdh31)

» show all

Reference

PMID:8459805

Authors

Bussemakers MJ, van Bokhoven A, Mees SG, Kemler R, Schalken JA

Title

Molecular cloning and characterization of the human E-cadherin cDNA.

Journal

Mol Biol Rep 17:123-8 (1993)
DOI:10.1007/bf00996219

Sequence

[hsa:999]

Reference

PMID:16417575

Authors

Agiostratidou G, Muros RM, Shioi J, Marambaud P, Robakis NK

Title

The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors.

Journal

J Neurochem 96:1182-8 (2006)
DOI:10.1111/j.1471-4159.2005.03616.x

LinkDB

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