KEGG ORTHOLOGY: K06619

ORTHOLOGY: K06619

Entry

K06619                      KO

Symbol

ABL1

Name

abelson tyrosine-protein kinase 1 [EC:2.7.10.2]

Pathway

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04110

Cell cycle

map04360

Axon guidance

map04722

Neurotrophin signaling pathway

map05130

Pathogenic Escherichia coli infection

map05200

Pathways in cancer

map05206

MicroRNAs in cancer

map05208

Chemical carcinogenesis - reactive oxygen species

map05220

Chronic myeloid leukemia

map05416

Viral myocarditis

Disease

H00001

B-cell acute lymphoblastic leukemia

H00004

Chronic myeloid leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K06619  ABL1; abelson tyrosine-protein kinase 1
   04014 Ras signaling pathway
    K06619  ABL1; abelson tyrosine-protein kinase 1
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06619  ABL1; abelson tyrosine-protein kinase 1
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06619  ABL1; abelson tyrosine-protein kinase 1
  09158 Development and regeneration
   04360 Axon guidance
    K06619  ABL1; abelson tyrosine-protein kinase 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06619  ABL1; abelson tyrosine-protein kinase 1
   05206 MicroRNAs in cancer
    K06619  ABL1; abelson tyrosine-protein kinase 1
   05208 Chemical carcinogenesis - reactive oxygen species
    K06619  ABL1; abelson tyrosine-protein kinase 1
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K06619  ABL1; abelson tyrosine-protein kinase 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K06619  ABL1; abelson tyrosine-protein kinase 1
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K06619  ABL1; abelson tyrosine-protein kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06619  ABL1; abelson tyrosine-protein kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K06619  ABL1; abelson tyrosine-protein kinase 1
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  ABL family
   K06619  ABL1; abelson tyrosine-protein kinase 1

Other DBs

GO:

0004715

Genes

HSA:

25(ABL1)

PTR:	107976801(ABL1)

PPS:	100994981(ABL1)

GGO:	101127165(ABL1)

PON:	100453216(ABL1)

PPYG:

129043627(ABL1)

NLE:	100601002(ABL1)

HMH:	116475772(ABL1)

SSYN:

129478772(ABL1)

MCC:	722449(ABL1)

MCF:	102115803(ABL1)

MTHB:

126936893

MNI:	105464039(ABL1)

CSAB:

103239742(ABL1)

CATY:

105576174(ABL1)

PANU:

101007628(ABL1)

TGE:	112607912(ABL1)

MLEU:

105532842(ABL1)

RRO:	104660552(ABL1)

RBB:	108513941(ABL1)

TFN:	117073329(ABL1)

PTEH:

111545838(ABL1)

CANG:

105504013(ABL1)

CJC:	100398414(ABL1)

SBQ:	101046557(ABL1)

CIMI:

108282994(ABL1)

ANAN:

105721113(ABL1)

CSYR:

103258968(ABL1)

MMUR:

105865709(ABL1)

LCAT:

123646592(ABL1)

PCOQ:

105806618(ABL1)

OGA:	100961758(ABL1)

MMU:	11350(Abl1)

MCAL:

110289525(Abl1)

MPAH:

110318646(Abl1)

RNO:	311860(Abl1)

MCOC:

116089976(Abl1)

ANU:	117702844(Abl1)

ASYL:

127685208(Abl1)

MUN:	110558915(Abl1)

CGE:	100768098(Abl1)

MAUA:

101835549(Abl1)

PROB:

127222749(Abl1)

PLEU:

114703784(Abl1)

MORG:

121462621(Abl1)

MFOT:

126509448

AAMP:

119818860(Abl1)

NGI:	103727721(Abl1)

HGL:	101724428(Abl1)

CPOC:

100720976(Abl1)

CCAN:

109700215(Abl1)

DORD:

105989403(Abl1)

DSP:	122108952(Abl1)

PLOP:

125350456(Abl1)

NCAR:

124965033

MMMA:

107151996(Abl1)

ITI:	101956926(Abl1)

OCU:

100345909

OPI:	101517017(ABL1)

TUP:	102470554(ABL1)

GVR:	103605912(ABL1)

CFA:	491292(ABL1)

CLUD:

112677338(ABL1)

VVP:	112927987(ABL1)

VLG:	121472660(ABL1)

NPO:	129509941(ABL1) 129517984

AML:	100466468(ABL1)

UMR:	103670413(ABL1)

UAH:	113266525(ABL1)

UAR:	123775749(ABL1)

ELK:

111146116

LLV:

125083176

MPUF:

101689921(ABL1)

MNP:	132024324(ABL1)

MLK:	131813028(ABL1)

NVS:	122917157(ABL1)

ORO:	101370651(ABL1)

EJU:	114198844(ABL1)

ZCA:	113934229(ABL1)

MLX:	118017579(ABL1)

NSU:	110581439(ABL1)

LWW:	102739037(ABL1)

FCA:	101087622(ABL1)

PYU:	121035113(ABL1)

PCOO:

112871107(ABL1)

PBG:	122474547(ABL1)

PVIV:

125150238(ABL1)

LRUF:

124525633

LGF:	123593207(ABL1)

AJU:

106985340

PTG:	102949569(ABL1)

PPAD:

109250012(ABL1)

PUC:

125922598

PLEZ:

122205661(ABL1)

HHV:	120230153(ABL1)

BTA:	540876(ABL1)

BOM:	102266301(ABL1)

BIU:	109566554(ABL1)

BBUB:

102401862(ABL1)

BBIS:

105000878(ABL1)

CHX:	102184349(ABL1)

OAS:	101122941(ABL1)

BTAX:

128056857(ABL1)

CSUM:

138087388(ABL1)

ODA:	120852101(ABL1)

CCAD:

122442277(ABL1)

MREE:

136163693(ABL1)

OVR:	110126110(ABL1)

MBEZ:

129539895(ABL1)

SSC:	100524544(ABL1)

CFR:	102519310(ABL1)

CBAI:

105069698(ABL1)

CDK:	105092528(ABL1)

VPC:	102528583(ABL1)

BACU:

102998508(ABL1)

BMUS:

118897511(ABL1)

LVE:	103076172(ABL1)

OOR:	101281151(ABL1)

LALB:

132523271(ABL1)

DLE:	111177117(ABL1)

PCAD:

102988541(ABL1)

PSIU:

116755284(ABL1)

NASI:

112411335(ABL1)

ECB:	100069715(ABL1)

EPZ:	103562771(ABL1)

EAI:	106845390(ABL1)

MYB:	102255271(ABL1)

MYD:	102757649(ABL1)

MMYO:

118666952(ABL1)

MLF:	102433845(ABL1)

MDT:	132212489(ABL1)

MYUM:

139020682(ABL1)

PKL:	118706629(ABL1)

EFUS:

103296016(ABL1)

MNA:	107524646(ABL1)

DRO:	112306226(ABL1)

SHON:

118980343(ABL1)

AJM:	119059032(ABL1)

PDIC:

114508748(ABL1)

PHAS:

123823364(ABL1)

MMF:	118629546(ABL1)

PPAM:

129079203(ABL1)

HAI:	109380669(ABL1)

RFQ:	117031775(ABL1)

PALE:

102895947(ABL1)

PGIG:

120602712(ABL1)

PVP:	105298669(ABL1)

RAY:	107504550(ABL1)

MJV:	108408195(ABL1)

TOD:	119232154(ABL1)

SARA:

101539877(ABL1)

SFUM:

130018061(ABL1)

SETR:

126009522(ABL1)

LAV:	100677152(ABL1)

TMU:

101341732

ETF:	101659985(ABL1)

DNM:	101425834(ABL1)

MDO:	100619549(ABL1)

GAS:	123237223(ABL1)

SHR:	100930047(ABL1)

AFZ:

127550913

PCW:	110198907(ABL1)

TVP:	118843433(ABL1)

PBRV:

138147109(ABL1)

OAA:	100075676(ABL1)

TACU:

119927385(ABL1)

GGA:	417181(ABL1)

PCOC:

116234254(ABL1)

MGP:	100550407(ABL1)

CJO:	107321848(ABL1)

TPAI:

128073888(ABL1)

LMUT:

125702456(ABL1)

NMEL:

110406778(ABL1)

APLA:

101794358(ABL1)

ACYG:

106044113(ABL1)

CATA:

118252285(ABL1)

AFUL:

116496816(ABL1)

TGU:	100223450(ABL1)

LSR:	110477593(ABL1)

SCAN:

103818997(ABL1)

PMOA:

120507414(ABL1)

OTC:	121336931(ABL1)

PRUF:

121357526(ABL1)

ATRC:

139603285(ABL1)

GFR:	102042232(ABL1)

FAB:	101817037(ABL1)

OMA:	130260053(ABL1)

PHI:	102099348(ABL1)

PMAJ:

107212136(ABL1)

CCAE:

111937004(ABL1)

CCW:	104688306(ABL1)

CBRC:

103623154(ABL1)

ACOE:

138119540(ABL1)

ETL:	114073812(ABL1)

ZAB:	102064957(ABL1)

ZLE:	135454911(ABL1)

ACHL:

103810632(ABL1)

SVG:	106851350(ABL1)

MMEA:

130581774(ABL1)

HRT:	120761579(ABL1)

SATI:

136369739(ABL1)

CCIC:

134051586(ABL1)

FPG:	101918950(ABL1)

FCH:	102052443(ABL1)

CCRI:

104158789(ABL1)

NNT:	104403215(ABL1)

SHAB:

115617013(ABL1)

ACUN:

113486462(ABL1)

TALA:

104367901(ABL1)

ACHC:

115335151(ABL1)

HALD:

104319548(ABL1)

HLE:	104833903(ABL1)

AGEN:

126052129

HHAR:

128154358(ABL1)

GCL:

127023599

CSTI:

104562274(ABL1)

LDI:	104345908(ABL1)

MNB:	103773619(ABL1)

DPUB:

104296454(ABL1)

PPUS:

135189998(ABL1)

AVIT:

104274499(ABL1)

BRHI:

104492995(ABL1)

EGZ:	104129817(ABL1)

NNI:	104023169(ABL1)

PCRI:

104037001(ABL1)

PCAO:

104053087(ABL1)

PADL:

103915284(ABL1)

AFOR:

103905311(ABL1)

FGA:	104073213(ABL1)

GSTE:

104254435(ABL1)

CLV:	102086741(ABL1)

MUI:	104540363(ABL1)

PGUU:

104471226(ABL1)

PLET:

104622736(ABL1)

EHS:	104510506(ABL1)

CMAC:

104484644(ABL1)

CUCA:

104066807(ABL1)

TEO:	104379188(ABL1)

BREG:

104632121(ABL1)

OHA:	104329209(ABL1)

ACAR:

104529790(ABL1)

CPEA:

104389837(ABL1)

CVF:	104287507(ABL1)

RTD:	128917456(ABL1)

AAM:	106486072(ABL1)

AROW:

112964293(ABL1)

NPD:	112955850(ABL1)

TGT:	104564563(ABL1)

DNE:	112984139(ABL1)

SCAM:

104138266(ABL1)

ASN:	102368526(ABL1)

AMJ:	102564337(ABL1)

CPOO:

109313946(ABL1)

GGN:	109292969(ABL1)

PSS:	102455334(ABL1)

CMY:	102943857(ABL1)

CCAY:

125623674(ABL1)

DCC:	119844141(ABL1)

CPIC:

101935179(ABL1)

TST:	117889431(ABL1)

CABI:

116835135(ABL1)

MRV:	120386715(ABL1)

ACS:	100557530(abl1)

ASAO:

132763766(ABL1)

PVT:	110079629(ABL1)

SUND:

121936304(ABL1)

PBI:

103059276

PMUR:

107291344(ABL1)

CTIG:

120308714(ABL1)

TSR:	106554736(ABL1)

PGUT:

117676555(ABL1)

APRI:

131186059(ABL1)

PTEX:

113443816(ABL1)

NSS:	113428766(ABL1)

VKO:	123028336(ABL1)

PMUA:

114589465(ABL1)

PRAF:

128406571(ABL1)

ZVI:	118083916(ABL1)

HCG:	128339062(ABL1)

GJA:	107108928(ABL1)

STOW:

125441669(ABL1)

EMC:	129342072(ABL1)

XLA:	108699954(abl1.S) 108704697(abl1.L)

XTR:	100490771(abl1)

NPR:	108788711(ABL1)

RTEM:

120914143(ABL1)

BBUF:

121009124(ABL1)

BGAR:

122919939 122919940

PWL:	138299081(ABL1)

MUO:	115473135(ABL1)

GSH:	117367705(ABL1)

DRE:	100000720(abl1)

SRX:	107729293 107745339(abl1)

SANH:

107670387 107674916

SGH:	107566858 107577903 107597931

CCAR:

109048738(abl1) 109057589

CAUA:

113048747 113084559

CGIB:

127957706 127992700

PTET:

122342963(abl1)

LROH:

127165996(abl1)

OMC:	131540037(abl1)

PPRM:

120472006(abl1)

RKG:	130079690(abl1)

MAMB:

125267851(abl1)

CIDE:

127512611

CERY:

137033676(abl1)

MASI:

127422653 127435472

TROS:

130565259(abl1)

TDW:	130420154(abl1)

MANU:

129440755(abl1)

PDAB:

135774118(abl1)

IPU:

108259985

IFU:	128603323(abl1)

PHYP:

113531133(abl1)

SMEO:

124378757(abl1)

TFD:	113634151(abl1)

TVC:	132840762(abl1)

CGAR:

128512166(abl1)

NGRA:

132875766(abl1)

TRN:	134303549(abl1)

AMEX:

103046185(abl1)

CMAO:

118814533(abl1)

EEE:

113583945

CHAR:

105889585(abl1)

SPIL:

134100839(abl1)

TRU:	101064177(abl1)

TFS:	130516880(abl1)

TNG:	GSTEN00017201G001

LCO:	104924853(abl1)

NCC:	104956356(abl1)

TBEN:

117476827(abl1)

CGOB:

115016527(abl1)

PGEO:

117456025(abl1)

GACU:

117538441(abl1)

EMAC:

134867976(abl1)

ELY:	117269831(abl1)

EFO:	125905906(abl1)

PLEP:

121959503(abl1)

SLUC:

116035156(abl1)

ECRA:

117959703(abl1)

ESP:	116704534(abl1)

PFLV:

114570717(abl1)

GAT:	120831583(abl1)

PPUG:

119227134(abl1)

AFB:	129102108(abl1)

CLUM:

117740539(abl1)

PSWI:

130204911(abl1)

CANA:

137783695(abl1)

CVE:	137869085(abl1)

MSAM:

119914667(abl1)

SCHU:

122865161(abl1)

CUD:	121524967(abl1)

SPUL:

138601913(abl1)

LMIX:

132991789(abl1)

ALAT:

119029983(abl1)

ASTR:

137607998(abl1)

MZE:	101475377(abl1)

ONL:	100709901(abl1)

OAU:	116322539(abl1)

OLA:	101155287(abl1)

OML:	112163252(abl1)

CSAI:

133455184(abl1)

XMA:	102230386(abl1)

XCO:	114149479(abl1)

XHE:	116723812(abl1)

PRET:

103473791(abl1)

PFOR:

103149563(abl1)

PLAI:

106944514(abl1)

PMEI:

106924238(abl1)

GAF:	122819488(abl1)

PPRL:

129366410(abl1)

CVG:	107088442(abl1)

CTUL:

119781545(abl1)

GMU:	124872546(abl1)

NFU:	107374064(abl1)

KMR:	108230984(abl1)

ALIM:

106532564(abl1)

NWH:	119424800(abl1)

AOCE:

111578179(abl1)

EJA:	138212009(abl1)

BFRE:

138629827(abl1)

MCEP:

124996911(abl1)

CSEM:

103390173(abl1)

POV:

109626307

SSEN:

122758241(abl1)

SSOE:

131445973(abl1)

HHIP:

117771273(abl1)

HSP:	118125412(abl1)

PPLT:

128462312(abl1)

SMAU:

118284470(abl1)

LCF:

108888951

SDU:	111237780(abl1)

SLAL:

111664729(abl1)

XGL:	120806168(abl1)

HCQ:

109514691

SSCV:

125979908(abl1)

SBIA:

133491193(abl1)

PEE:	133414254(abl1)

PTAO:

133489947(abl1)

BPEC:

110160463(abl1)

MALB:

109960591

BSPL:

114866570(abl1)

SJO:	128380509(abl1)

SSCO:

133995088(abl1)

GMH:	115541408(abl1)

SASA:

106563284 106566947

STRU:

115159563 115204069

OTW:	112219306 112230988

OMY:	110509795 110523582

OGO:	124006697 124048965

ONE:	115101169 115122653

OKI:	109873830 109879859

OKE:	118373067 118385296

OMM:	135517982(abl1) 135544468

OCLA:

139388717 139408629

SALP:

111961611 111964018

SNH:	120021211 120025692

CCLU:

121541667 121582511

ELS:	105015016(abl1)

SFM:	108922661 108938597

PKI:	111842668 111843474

AANG:

118206601 118212827

AROT:

135238980(abl1) 135265178

CCOG:

133140505 133141802

LOC:

102691842

PSPA:

121309712(abl1)

ARUT:

117396922 117422371

PSEX:

120536002(abl1)

LCM:	102355014(ABL1)

CMK:	103183028(abl1)

RTP:

109930229

CPLA:

122564979(abl1)

HOC:

132825933

LERI:

129712049(abl1)

PMRN:

116938389 116944865 116953228(ABL1)

LRJ:	133341743 133354609(ABL1)

BFO:

118420419

BBEL:

109461989 109461990 109470447 109484645

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:	100374571(ABL2)

PFLL:

139114561

DME:	Dmel_CG4032(Abl)

DER:

6544214

DSE:

6605990

DYA:	Dyak_GE22200

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16710

DAZ:

108613380

DNV:

108652076

DHE:

111592453

DVI:	6622922(Abl)

CCAT:

101454326

BOD:

106621447

BDR:

105232686

RZE:	108377132 108382813

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135953071(Abl)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003985 CpipJ_CPIJ009602

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139112203(Abl)

TLN:	139821222(Abl)

HST:

DQU:

CFO:

FEX:

PMEC:

138933110(Abl)

LHU:	105670007(Abl)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

AROA:

TCA:

TMOL:

138122300(Abl)

DPA:

109544745

ESIM:

136415409(Abl)

EFOR:

136344461(Abl)

SOY:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200085

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137933271(Abl)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106691188(Abl)

NLU:

111062204

HVI:

124369193

MQU:

128993820

PHU:	Phum_PHUM538010

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139689510(Abl)

FCD:

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

CQD:	128704563(Abl)

PTRU:

123513640

ESN:

126999574

MNZ:

135202578

MRJ:	136847430(Abl)

PORN:

139750251(Abl)

HAZT:

108667055 108667702

EAF:	111716984 111717929

LSM:	121124891(Abl)

TCF:	131889157 131889158

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136990906(Abl)

PTEP:

107439649 107446009

ABRU:

129963230 129980968

UDV:	129216726 129222372

SDM:	118185970 118186282

CEL:	CELE_M79.1(abl-1)

CBR:	CBG_04507(Cbr-abl-1)

NAI:	NECAME_06130

BMY:	BM_BM5124(Bma-abl-1)

LOA:	LOAG_05868

TSP:

Tsp_09251

HRO:	HELRODRAFT_166124

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:	124259814 124269735

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_128790 Smp_169230

SHX:	MS3_00006730(ABL2_1) MS3_00010068(ABL2_2)

OVI:	T265_05581 T265_08093

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

AQU:

TVS:	TRAVEDRAFT_171082

HIR:	HETIRDRAFT_124459

FME:	FOMMEDRAFT_17451

CCI:	CC1G_13961

E1B28_006705

MBR:	MONBRDRAFT_44322

SRE:	PTSG_06415 PTSG_08747

ACAN:

ACA1_065920 ACA1_307790

» show all

Reference

PMID:20841568

Authors

Colicelli J

Title

ABL tyrosine kinases: evolution of function, regulation, and specificity.

Journal

Sci Signal 3:re6 (2010)
DOI:10.1126/scisignal.3139re6

Sequence

[hsa:25]

LinkDB

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