Entry Symbol tcmN
Name multifunctional cyclase / dehydratase / O-methyltransferase [EC:
2.3.1.235 ]
Pathway map01056 Biosynthesis of type II polyketide backbone
map01057 Biosynthesis of type II polyketide products
map01110 Biosynthesis of secondary metabolites
Module M00778 Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
M00783 Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Reaction R10960 malonyl-CoA:acetate malonyltransferase (tetracenomycin-F2-forming)
Brite KEGG Orthology (KO) [BR:ko00001 ]ko01000 ]ko01008 ] BRITE hierarchy Genes Taxonomy UniProt Reference Authors Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
Title Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.
Journal Sequence Reference Authors Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC
Title Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.
Journal LinkDB All DBs
