KEGG   ORTHOLOGY: K17726
Entry
K17726            Tight     KO                                     
Symbol
CYP4F2_3
Name
phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase [EC:1.14.14.78 1.14.14.79 1.14.14.94]
Pathway
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
Reaction
R03866  (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (20-hydroxylating)
R07041  arachidonic acid:oxygen 1-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17726  CYP4F2_3; phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17726  CYP4F2_3; phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.78  phylloquinone omega-hydroxylase
     K17726  CYP4F2_3; phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
    1.14.14.79  docosahexaenoic acid omega-hydroxylase
     K17726  CYP4F2_3; phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
    1.14.14.94  leukotriene-B4 20-monooxygenase
     K17726  CYP4F2_3; phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP4 family
   K17726  CYP4F2_3; phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
Other DBs
GO: 0050051
Genes
HSA: 4051(CYP4F3) 8529(CYP4F2)
PTR: 100609185 748117(CYP4F3) 748531(CYP4F2)
PPS: 100967411(CYP4F2) 100969141(CYP4F3)
GGO: 101125692 101135418 101152881
PON: 100434096 100437847 100453229
PPYG: 129020906 129020916
NLE: 100579320 100588006 115836968
HMH: 116478624 116478627
SSYN: 129459452 129460821
MCC: 718349 719317
MCF: 102130440(CYP4F3) 102134301(CYP4F2)
MTHB: 126942252 126942253
MNI: 105494188 105494717
CSAB: 103234079 103234089
CATY: 105601614 105601627
PANU: 101005940 101010705
TGE: 112612404 112613097
MLEU: 105540101 105540126
RRO: 104661012 104661014
RBB: 108543262 108543288 108543294
TFN: 117076174
PTEH: 111554233 111554287
CANG: 105519773 105519778
CJC: 100411160 100412575
SBQ: 101050944 101051361
CIMI: 108298561(CYP4F2)
ANAN: 105729220 105729221
CSYR: 103250633
MMUR: 105867925 105867928 105867931 105867933
LCAT: 123629269 123634142 123636956 123636960 123636967 123639775 123639780
PCOQ: 105810118 105825072 105825741 105827104
OGA: 100942215 100943471 100952962
CPOC: 100733735
OCU: 100348038 100350957
TUP: 102483333
GVR: 103593427 103610570
VLG: 121495723
UAR: 123779961 123780007
LLV: 125083145
ZCA: 113917975
MLX: 118005050
CHX: 102183680
BTAX: 128050384
ODA: 120864165
MLF: 102425173 102436085
MDT: 132234883 132234884
MYUM: 139009921
PKL: 118706555
DRO: 112305042
PDIC: 114503445
RFQ: 117038128
PGIG: 120606485
PVP: 105311420
RAY: 107517263
TOD: 119240020
LAV: 100657832 100659260
DNM: 101441145
 » show all
Reference
PMID:8026587 (CYP4F2)
  Authors
Kikuta Y, Kusunose E, Kondo T, Yamamoto S, Kinoshita H, Kusunose M
  Title
Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.
  Journal
FEBS Lett 348:70-4 (1994)
DOI:10.1016/0014-5793(94)00587-7
  Sequence
[hsa:8529]
Reference
PMID:8486631 (CYP4F3)
  Authors
Kikuta Y, Kusunose E, Endo K, Yamamoto S, Sogawa K, Fujii-Kuriyama Y, Kusunose M
  Title
A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase.
  Journal
J Biol Chem 268:9376-80 (1993)
  Sequence
[hsa:4051]
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