KEGG   ORTHOLOGY: K18590
Entry
K18590                      KO                                     
Symbol
dfrA12, dhfr
Name
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Pathway
map00670  One carbon pool by folate
map00790  Folate biosynthesis
map01100  Metabolic pathways
Reaction
R00936  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00937  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00939  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R00940  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R02235  dihydrofolate:NAD+ oxidoreductase
R02236  dihydrofolate:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K18590  dfrA12, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
   00670 One carbon pool by folate
    K18590  dfrA12, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18590  dfrA12, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K18590  dfrA12, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    K18590  dfrA12, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance: KEGG signatures [br01600.html]
 Signature KOs for antimicrobial resistance
  K18590
Other DBs
COG: COG0262
GO: 0004146
Genes
SEM: STMDT12_L00660
SETU: STU288_1p00755
SEC: SCH_030(tri)
KPM: KPHS_p300720
KPH: KPNIH24_26865
KPG: KPNIH32_28345
KPC: KPNIH10_26700
KPJ: N559_5185
KPX: PMK1_ndm00220(dfrA)
KPNE: KU54_01505
KPNU: LI86_26830
KOE: A225_R1p0770
CIE: AN232_27650
CIX: M4I31_16785(dfrA12)
PRQ: CYG50_00670(dfrA12)
PTW: TUM18999_61460
HNA: Hneap_1653
AAJ: BOQ57_11310
AEA: C2U39_22030
AES: C2U30_02785
PMEG: FNZ07_10935
NARM: N7E01_05245(dfrA12) N7E01_05350(dfrA12)
ROL: CA51_49230(dfrA)
BVO: Pan97_43470(dfrA_1)
AMUC: Pan181_15640(dfrA)
TRI: DYE50_00150
MLEN: H3V22_01695
CSCI: HDCHBGLK_01250(folA)
ACEL: acsn021_21150
AARG: Aargi30884_28250 Aargi30884_29140
NBE: Back2_01160(folA)
AG: AAS66087(dfrA21) CAA79767(dfrA12) CAA90683(dfrA13) CAF31623(dfrA22) CAX16467(dfrA33)
 » show all
Reference
PMID:10639362
  Authors
Adrian PV, Thomson CJ, Klugman KP, Amyes SG
  Title
New gene cassettes for trimethoprim resistance, dfr13, and Streptomycin-spectinomycin resistance, aadA4, inserted on a class 1 integron.
  Journal
Antimicrob Agents Chemother 44:355-61 (2000)
DOI:10.1128/AAC.44.2.355-361.2000
Reference
PMID:23162539
  Authors
Roberts MC, Schwarz S, Aarts HJ
  Title
Erratum: Acquired antibiotic resistance genes: an overview.
  Journal
Front Microbiol 3:384 (2012)
DOI:10.3389/fmicb.2012.00384
Reference
PMID:11432417
  Authors
Skold O
  Title
Resistance to trimethoprim and sulfonamides.
  Journal
Vet Res 32:261-73 (2001)
DOI:10.1051/vetres:2001123
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