KEGG   ORTHOLOGY: K21036
Entry
K21036                      KO                                     
Symbol
vldW
Name
validamycin A dioxygenase [EC:1.14.11.52]
Pathway
map00525  Acarbose and validamycin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R11340  validamycin-A,2-oxoglutarate:oxygen oxidoreductase (6'-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K21036  vldW; validamycin A dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.52  validamycin A dioxygenase
     K21036  vldW; validamycin A dioxygenase
Other DBs
COG: COG3491
Genes
SHY: SHJG_0280 SHJG_0285
SHO: SHJGH_0114 SHJGH_0119
SINE: KI385_04775
STRV: EZV63_03150
STRH: GXP74_22190
AG: ABC67263(vldW)
Reference
PMID:16725283
  Authors
Singh D, Seo MJ, Kwon HJ, Rajkarnikar A, Kim KR, Kim SO, Suh JW
  Title
Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704).
  Journal
Gene 376:13-23 (2006)
DOI:10.1016/j.gene.2005.12.035
  Sequence
[ag:ABC67263]
Reference
PMID:22961651
  Authors
Almabruk KH, Asamizu S, Chang A, Varghese SG, Mahmud T
  Title
The alpha-ketoglutarate/Fe(II)-dependent dioxygenase VldW is responsible for the formation of validamycin B.
  Journal
Chembiochem 13:2209-11 (2012)
DOI:10.1002/cbic.201200464
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