KEGG ORTHOLOGY: K21184

ORTHOLOGY: K21184

Entry

K21184                      KO

Symbol

sgcC, mdpC

Name

two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-]

Pathway

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00827

C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP

Reaction

R10731

(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein],FADH2:oxygen oxidoreductase (5-hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21184  sgcC, mdpC; two-component FAD-dependent monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21184  sgcC, mdpC; two-component FAD-dependent monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.15  (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase
     K21184  sgcC, mdpC; two-component FAD-dependent monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Oxygenase
   K21184  sgcC, mdpC; two-component FAD-dependent monooxygenase

Other DBs

COG:

COG2368

Genes

SCOR:

SGB:

STRM:

SPLU:

STIR:

SSPO:

SGK:	PET44_34970

SFIY:

F0344_34985

KIT:	CFP65_1236

AGRO:

JSQ78_00590

THAO:

NI17_008205

SRO:

Sros_6973

NGN:	LCN96_24240

AJA:	AJAP_16305(nphA1)

AMYB:

BKN51_28900

AAB:	A4R43_37265

AMYY:

YIM_40820(nphA2)

AROO:

NQK81_30290

AMOG:

QRX60_50945 QRX60_51025 QRX60_51070

ANW:	QP939_27945

AMYS:

CVV72_40575

SESP:

BN6_39070

KPHY:

AOZ06_26420 AOZ06_30980

ACTI:

UA75_18095

ACAD:

UA74_17570

AHG:	AHOG_16485(nphA1)

ACTA:

C1701_26500

ALO:

CRK59465

ACTU:

Actkin_05231(nphA1)

UME:	RM788_41485

STP:	Strop_2713

SAQ:

MSAG:

MCAY:

PFLA:

PRY:	Prubr_50750

AG:	ABY66026(mdpC)

» show all

Reference

PMID:18426211

Authors

Lin S, Van Lanen SG, Shen B

Title

Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

J Am Chem Soc 130:6616-23 (2008)
DOI:10.1021/ja710601d

Reference

PMID:12183628 (sgcC)

Authors

Liu W, Christenson SD, Standage S, Shen B

Title

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

Science 297:1170-3 (2002)
DOI:10.1126/science.1072110

Sequence

[sgb:WQO_33855]

LinkDB

DBGET integrated database retrieval system