KEGG   ORTHOLOGY: K22271
Entry
K22271            Tight     KO                                     
Symbol
Core
Name
Hepatitis C virus core protein
Pathway
map03230  Viral genome structure
map03272  Virion - Hepatitis viruses
map05160  Hepatitis C
map05203  Viral carcinogenesis
Network
nt06163  Hepatitis C virus (HCV)
nt06222  IFN signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06516  TNF signaling
nt06517  TLR signaling
nt06524  Apoptosis
  Element
N00269  HCV core to TNF-NFKB signaling pathway
N00270  HCV Core to IFN signaling pathway
N00518  HCV Core to ERK signaling pathway
N00519  HCV Core to ERK signaling pathway
N00521  HCV Core to p21-cell cycle G1/S
N00523  HCV Core to p21-cell cycle G1/S
N00527  HCV Core to crosstalk between extrinsic and intrinsic apoptotic pathways
N00528  HCV core to extrinsic apoptotic pathway
N00529  HCV core to RXRA/PPARA-mediated transcription
N00530  HCV core to RXRA/LXRA-mediated transcription
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22271  Core; Hepatitis C virus core protein
   03272 Virion - Hepatitis viruses
    K22271  Core; Hepatitis C virus core protein
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K22271  Core; Hepatitis C virus core protein
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22271  Core; Hepatitis C virus core protein
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22271  Core; Hepatitis C virus core protein
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus (Hepacivirus C)
   K22271  Core; Hepatitis C virus core protein
Genes
VP: 951475-1(p21)
Reference
PMID:23490391
  Authors
Gouklani H, Beyer C, Drummer H, Gowans EJ, Netter HJ, Haqshenas G
  Title
Identification of specific regions in hepatitis C virus core, NS2 and NS5A that genetically interact with p7 and co-ordinate infectious virus production.
  Journal
J Viral Hepat 20:e66-71 (2013)
DOI:10.1111/jvh.12004
  Sequence
[vp:951475-1]
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
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