KEGG   ORTHOLOGY: K25009
Entry
K25009                      KO                                     
Symbol
E1.5.1.20
Name
methylenetetrahydrofolate reductase [NAD(P)H] [EC:1.5.1.20]
Pathway
map00670  One carbon pool by folate
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R01224  5-methyltetrahydrofolate:NADP+ oxidoreductase
R07168  5-methyltetrahydrofolate:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K25009  E1.5.1.20; methylenetetrahydrofolate reductase [NAD(P)H]
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.20  methylenetetrahydrofolate reductase [NAD(P)H]
     K25009  E1.5.1.20; methylenetetrahydrofolate reductase [NAD(P)H]
Other DBs
GO: 0004489
Genes
BPHI: 137932138
LMA: LMJF_36_6390
LIF: LINJ_36_6670
LDO: LDBPK_366670
LMI: LMXM_36_6390
LMAT: 92510831(LSCM1_00677)
LBZ: LBRM_35_6720
LPAN: LPMP_356560
LOI: 92356693(LSCM4_00683)
LEIS: 94176326(GH5_00690)
LENR: 94167975(CUR178_00684)
LEIN: 94184455(JIQ42_00694)
PHET: 94287054(JKF63_00928)
 » show all
Reference
PMID:17032644
  Authors
Vickers TJ, Orsomando G, de la Garza RD, Scott DA, Kang SO, Hanson AD, Beverley SM.
  Title
Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.
  Journal
J Biol Chem 281:38150-8 (2006)
DOI:10.1074/jbc.M608387200
  Sequence
[lma:LMJF_36_6390]
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