Entry Name IGF-IGFR-PI3K-NFKB signaling pathway
Definition IGF1 -> IGF1R -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB
Expanded 3479 -> 3480 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class nt06214 PI3K signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type Reference
Pathway Gene 3479 IGF1; insulin like growth factor 1
3480 IGF1R; insulin like growth factor 1 receptor
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
1147 CHUK; conserved helix-loop-helix ubiquitous kinase
3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517 IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792 NFKBIA; NFKB inhibitor alpha
4790 NFKB1; nuclear factor kappa B subunit 1
5970 RELA; RELA proto-oncogene, NF-kB subunit
Metabolite C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Salminen A, Kaarniranta K
Title Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling.
Journal Reference Authors Jimenez Del Rio M, Velez-Pardo C
Title Insulin-like growth factor-1 prevents Abeta[25-35]/(H2O2)- induced apoptosis in lymphocytes by reciprocal NF-kappaB activation and p53 inhibition via PI3K-dependent pathway.
Journal Reference Authors Bai D, Ueno L, Vogt PK
Title Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt.
Journal LinkDB All DBs
