| Entry |
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| Name |
PDL/PD1-SHP-PI3K signaling pathway
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| Definition |
(PDL1,PDL2) -> PDCD1 -> SHP1/2 -| PI3Kdelta |
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| Expanded |
(29126,80380) -> 5133 -> (5777,5781) -| (5293+(5295,5296,8503)) |
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| Class |
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| Type |
Reference
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| Pathway |
| hsa04660 | T cell receptor signaling pathway |
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| Gene |
| 29126 | CD274; CD274 molecule |
| 80380 | PDCD1LG2; programmed cell death 1 ligand 2 |
| 5133 | PDCD1; programmed cell death 1 |
| 5777 | PTPN6; protein tyrosine phosphatase non-receptor type 6 |
| 5781 | PTPN11; protein tyrosine phosphatase non-receptor type 11 |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 5295 | PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 |
| 5296 | PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 |
| 8503 | PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 |
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| Reference |
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| Authors |
Sharpe AH, Pauken KE |
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| Title |
The diverse functions of the PD1 inhibitory pathway. |
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| Journal |
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| Reference |
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| Authors |
Buchanan CM, Lee KL, Shepherd PR |
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| Title |
For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors. |
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| Journal |
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| Reference |
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| Authors |
McBride MA, Patil TK, Bohannon JK, Hernandez A, Sherwood ER, Patil NK |
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| Title |
Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression. |
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| Journal |
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| Reference |
|
|---|
| Authors |
Chinai JM, Janakiram M, Chen F, Chen W, Kaplan M, Zang X |
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| Title |
New immunotherapies targeting the PD-1 pathway. |
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| Journal |
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| LinkDB |
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