KEGG   NETWORK: N01695
Entry
N01695                      Network                                
Name
BCR-BCAP/CD19-PI3K signaling pathway
Definition
IGH -> (LYN,SYK) -> (PIK3AP1,(CD19+CD21+CD81+IFITM1)) -> PI3Kdelta -> PIP3 -> AKT
  Expanded
102723407 -> (4067,6850) -> (118788,(930+1380+975+8519)) -> (5293+(5295,5296,8503)) -> C05981 -> (207,208,10000)
Class
nt06537 TCR/BCR signaling
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04662  B cell receptor signaling pathway
Gene
102723407  IGH; immunoglobulin heavy variable 4-38-2-like
4067  LYN; LYN proto-oncogene, Src family tyrosine kinase
6850  SYK; spleen associated tyrosine kinase
118788  PIK3AP1; phosphoinositide-3-kinase adaptor protein 1
930  CD19; CD19 molecule
1380  CR2; complement C3d receptor 2
975  CD81; CD81 molecule
8519  IFITM1; interferon induced transmembrane protein 1
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:35402811
  Authors
Wen Y, Jing Y, Yang L, Kang D, Jiang P, Li N, Cheng J, Li J, Li X, Peng Z, Sun X, Miller H, Sui Z, Gong Q, Ren B, Yin W, Liu C
  Title
The regulators of BCR signaling during B cell activation.
  Journal
Blood Sci 1:119-129 (2019)
DOI:10.1097/BS9.0000000000000026
Reference
PMID:31443495
  Authors
Buchanan CM, Lee KL, Shepherd PR
  Title
For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors.
  Journal
Biomolecules 9:biom9090402 (2019)
DOI:10.3390/biom9090402
Reference
PMID:32348596
  Authors
Deenick EK, Lau A, Bier J, Kane A
  Title
Molecular and cellular mechanisms underlying defective antibody responses.
  Journal
Immunol Cell Biol 98:467-479 (2020)
DOI:10.1111/imcb.12345
Reference
PMID:27616589
  Authors
Lucas CL, Chandra A, Nejentsev S, Condliffe AM, Okkenhaug K
  Title
PI3Kdelta and primary immunodeficiencies.
  Journal
Nat Rev Immunol 16:702-714 (2016)
DOI:10.1038/nri.2016.93
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