KEGG   REACTION: R02840
Entry
R02840                      Reaction                               
Name
cortisol delta5-delat4-isomerase;
11beta,17alpha,21-trihydroxypregnenolone:NAD+ 3-oxidoreductase
Definition
Cortisol + H+ + NADH <=> 11beta,17alpha,21-Trihydroxypregnenolone + NAD+
Equation
C00735 + C00080 + C00004 <=> C05489 + C00003
Comment
NADPH (see R02842)
multi-step reaction (see R03176+R02644)
Reaction class
RC00001  C00003_C00004
RC00146  C00735_C05489
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R02840  Cortisol + H+ + NADH <=> 11beta,17alpha,21-Trihydroxypregnenolone + NAD+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R02840  Cortisol + H+ + NADH <=> 11beta,17alpha,21-Trihydroxypregnenolone + NAD+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
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