KEGG   REACTION: R13255
Entry
R13255                      Reaction                               
Name
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, NADH, very-long-chain acyl-CoA forming)
Definition
Acetyl-CoA + n Malonyl-CoA + n NADPH + n NADH + 2n H+ <=> Very-long-chain acyl-CoA + n CoA + n CO2 + n NADP+ + n NAD+ + n H2O
Equation
C00024 + n C00083 + n C00005 + n C00004 + 2n C00080 <=> C20876 + n C00010 + n C00011 + n C00006 + n C00003 + n C00001
Comment
Type I fatty acid synthase, bacteria type
multi-step reaction
Enzyme
2.3.1.-
Pathway
rn00074  Mycolic acid biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.-
     R13255  Acetyl-CoA + n Malonyl-CoA + n NADPH + n NADH + 2n H+ <=> Very-long-chain acyl-CoA + n CoA + n CO2 + n NADP+ + n NAD+ + n H2O
Orthology
K11533  fatty acid synthase, bacteria type [EC:2.3.1.-]
Reference
1  [PMID:26104214]
  Authors
PaweLczyk J, Kremer L
  Title
The Molecular Genetics of Mycolic Acid Biosynthesis.
  Journal
Microbiol Spectr 2:MGM2-0003-2013 (2014)
DOI:10.1128/microbiolspec.MGM2-0003-2013
Reference
2  [PMID:21204864]
  Authors
Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H.
  Title
Fatty acid biosynthesis in actinomycetes.
  Journal
FEMS Microbiol Rev 35:475-97 (2011)
DOI:10.1111/j.1574-6976.2010.00259.x
Reference
3  [PMID:24374164]
  Authors
Marrakchi H, Laneelle MA, Daffe M.
  Title
Mycolic acids: structures, biosynthesis, and beyond.
  Journal
Chem Biol 21:67-85 (2014)
DOI:10.1016/j.chembiol.2013.11.011
Reference
4  [PMID:27268593]
  Authors
Quemard A.
  Title
New Insights into the Mycolate-Containing Compound Biosynthesis and Transport in  Mycobacteria.
  Journal
Trends Microbiol 24:725-738 (2016)
DOI:10.1016/j.tim.2016.04.009
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