KEGG   REACTION: R13334
Entry
R13334                      Reaction                               
Name
malonyl-CoA:17,18-epoxy-17-hydroxycur-19-ene N-malonyltransferase
Definition
Wieland-Gumlich aldehyde + Malonyl-CoA <=> Prestrychnine + CoA
Equation
C22925 + C00083 <=> C22927 + C00010
Comment
BAHD acyltransferase
Reaction class
RC03590  C22925_C22927
Enzyme
2.3.1.325
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00980  Strychnine biosynthesis, geissoschizine => strychnine
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.325
     R13334  Wieland-Gumlich aldehyde + Malonyl-CoA <=> Prestrychnine + CoA
Orthology
K27784  17,18-epoxy-17-hydroxycur-19-ene N-malonyltransferase [EC:2.3.1.325]
Reference
1  [PMID:35794473]
  Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
  Title
Biosynthesis of strychnine.
  Journal
Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4
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