REACTION: R13335
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Entry
R13335 Reaction
Name
acetyl-CoA:(19E)-17,18-epoxy-17-hydroxycur-19-ene N-acetyltransferase
Definition
Wieland-Gumlich aldehyde + Acetyl-CoA <=> Diaboline + CoA
Equation
C22925
+
C00024
<=>
C22926
+
C00010
Comment
BAHD acyltransferase
Reaction class
RC03590
C22925_C22926
Enzyme
2.3.1.326
Pathway
rn00901
Indole alkaloid biosynthesis
rn01110
Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:
br08201
]
2. Transferase reactions
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.326
R13335 Wieland-Gumlich aldehyde + Acetyl-CoA <=> Diaboline + CoA
BRITE hierarchy
Orthology
K27785
(19E)-17,18-epoxy-17-hydroxycur-19-ene N-acetyltransferase [EC:
2.3.1.326
]
Reference
1 [PMID:
35794473
]
Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
Title
Biosynthesis of strychnine.
Journal
Nature 607:617-622 (2022)
DOI:
10.1038/s41586-022-04950-4
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