KEGG   REACTION: R13340
Entry
R13340                      Reaction                               
Name
beta-colubrine,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (11-hydroxylating)
Definition
beta-Colubrine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 11-Demethylbrucine + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C22930 + C03024 + C00007 <=> C22931 + C03161 + C00001
Reaction class
RC00046  C22930_C22931
Enzyme
1.14.14.190
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.190
     R13340  beta-Colubrine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 11-Demethylbrucine + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K27788  beta-colubrine 11-hydroxylase [EC:1.14.14.190]
Reference
1  [PMID:35794473]
  Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
  Title
Biosynthesis of strychnine.
  Journal
Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4
LinkDB

DBGET integrated database retrieval system