KEGG   REACTION: R13342
Entry
R13342                      Reaction                               
Definition
(19E)-Geissoschizine + Oxygen + [Reduced NADPH---hemoprotein reductase] + H+ <=> 3,17-Didehydrostemmadenine + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C02151 + C00007 + C03024 + C00080 <=> C22936 + C03161 + 2 C00001
Comment
the first step of four-step reaction (see R13381, R13342+R13329+R13382+R13331)
Enzyme
1.14.19.80
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
M00980  Strychnine biosynthesis, geissoschizine => strychnine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.80
     R13342  (19E)-Geissoschizine + Oxygen + [Reduced NADPH---hemoprotein reductase] + H+ <=> 3,17-Didehydrostemmadenine + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Orthology
K27780  (19E)-geissoschizine oxidase [EC:1.14.19.80]
Reference
1  [PMID:29511102]
  Authors
Qu Y, Easson MEAM, Simionescu R, Hajicek J, Thamm AMK, Salim V, De Luca V
  Title
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine.
  Journal
Proc Natl Acad Sci U S A 115:3180-3185 (2018)
DOI:10.1073/pnas.1719979115
Reference
2  [PMID:37626942]
  Authors
Salim V, Jarecki SA, Vick M, Miller R.
  Title
Advances in Metabolic Engineering of Plant Monoterpene Indole Alkaloids.
  Journal
Biology (Basel) 12:biology12081056 (2023)
DOI:10.3390/biology12081056
LinkDB

DBGET integrated database retrieval system