KEGG   REACTION: R13343
Entry
R13343                      Reaction                               
Name
acetyl-CoA:stemmadenine O-acetyltransferase
Definition
Stemmadenine + Acetyl-CoA <=> Stemmadenine acetate + CoA
Equation
C11691 + C00024 <=> C22933 + C00010
Reaction class
RC00041  C11691_C22933
Enzyme
2.3.1.323
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.323
     R13343  Stemmadenine + Acetyl-CoA <=> Stemmadenine acetate + CoA
Orthology
K27791  stemmadenine O-acetyltransferase [EC:2.3.1.323]
Reference
1  [PMID:36045295]
  Authors
Zhang J, Hansen LG, Gudich O, Viehrig K, Lassen LMM, Schrubbers L, Adhikari KB, Rubaszka P, Carrasquer-Alvarez E, Chen L, D'Ambrosio V, Lehka B, Haidar AK, Nallapareddy S, Giannakou K, Laloux M, Arsovska D, Jorgensen MAK, Chan LJG, Kristensen M, Christensen HB, Sudarsan S, Stander EA, Baidoo E, Petzold CJ, Wulff T, O'Connor SE, Courdavault V, Jensen MK, Keasling JD.
  Title
A microbial supply chain for production of the anti-cancer drug vinblastine.
  Journal
Nature 609:341-347 (2022)
DOI:10.1038/s41586-022-05157-3
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