KEGG REACTION: R13467

REACTION: R13467

Entry

R13467                      Reaction

Name

3-oxochol-4-en-24-oyl-CoA:propanoyl-CoA C-acyltransferase

Definition

3,24-Dioxocholest-4-en-26-oyl-CoA + CoA <=> 3-Oxochol-4-en-24-oyl-CoA + Propanoyl-CoA

Equation

C23013 + C00010 <=> C21906 + C00100

Enzyme

2.3.1.16

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.16
     R13467  3,24-Dioxocholest-4-en-26-oyl-CoA + CoA <=> 3-Oxochol-4-en-24-oyl-CoA + Propanoyl-CoA

Orthology

K00632

acetyl-CoA acyltransferase [EC:2.3.1.16]

Reference

1 [PMID:25482540]

Authors

Schaefer CM, Lu R, Nesbitt NM, Schiebel J, Sampson NS, Kisker C.

Title

FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis.

Journal

Structure 23:21-33 (2015)
DOI:10.1016/j.str.2014.10.010

Reference

2 [PMID:19822655]

Authors

Nesbitt NM, Yang X, Fontan P, Kolesnikova I, Smith I, Sampson NS, Dubnau E

Title

A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.

Journal

Infect Immun 78:275-82 (2010)
DOI:10.1128/IAI.00893-09

LinkDB

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