Homo sapiens (human): 1499
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Entry
1499 CDS
T01001
Symbol
CTNNB1, CTNNB, EVR7, MRD19, NEDSDV, armadillo
Name
(RefSeq) catenin beta 1
KO
K02105
catenin beta 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04015
Rap1 signaling pathway
hsa04310
Wnt signaling pathway
hsa04390
Hippo signaling pathway
hsa04510
Focal adhesion
hsa04520
Adherens junction
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04670
Leukocyte transendothelial migration
hsa04916
Melanogenesis
hsa04919
Thyroid hormone signaling pathway
hsa04934
Cushing syndrome
hsa04936
Alcoholic liver disease
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05100
Bacterial invasion of epithelial cells
hsa05132
Salmonella infection
hsa05160
Hepatitis C
hsa05163
Human cytomegalovirus infection
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05210
Colorectal cancer
hsa05213
Endometrial cancer
hsa05215
Prostate cancer
hsa05216
Thyroid cancer
hsa05217
Basal cell carcinoma
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05412
Arrhythmogenic right ventricular cardiomyopathy
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181
Salmonella
nt06215
WNT signaling (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06274
Thyroid cancer
nt06505
WNT signaling
Element
N00056
Wnt signaling pathway
N00057
Mutation-inactivated APC to Wnt signaling pathway
N00058
Mutation-activated CTNNB1 to Wnt signaling pathway
N00059
FZD7-overexpression to Wnt signaling pathway
N00060
LRP6-overexpression to Wnt signaling pathway
N00061
CDH1-reduced expression to beta-catenin signaling pathway
N00175
KSHV LANA to Wnt signaling pathway
N00242
Mutation-inactivated AXIN to Wnt signaling pathway
N00257
Loss of CDH1 to beta-catenin signaling pathway
N00258
Mutation-inactivated CDH1 to beta-catenin signaling pathway
N01124
Salmonella AvrA to beta-catenin signaling pathway
Disease
H00018
Gastric cancer
H00020
Colorectal cancer
H00026
Endometrial cancer
H00027
Ovarian cancer
H00032
Thyroid cancer
H00048
Hepatocellular carcinoma
H00589
Familial exudative vitreoretinopathy
H00773
Autosomal dominant intellectual developmental disorder
H00947
Pilomatricoma
H01667
Medulloblastoma
H02301
Nephroblastoma
H02302
Hepatoblastoma
Drug target
Foscenvivint:
D12445
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
1499 (CTNNB1)
04310 Wnt signaling pathway
1499 (CTNNB1)
04390 Hippo signaling pathway
1499 (CTNNB1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
1499 (CTNNB1)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
1499 (CTNNB1)
09152 Endocrine system
04919 Thyroid hormone signaling pathway
1499 (CTNNB1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
1499 (CTNNB1)
05205 Proteoglycans in cancer
1499 (CTNNB1)
09162 Cancer: specific types
05210 Colorectal cancer
1499 (CTNNB1)
05225 Hepatocellular carcinoma
1499 (CTNNB1)
05226 Gastric cancer
1499 (CTNNB1)
05216 Thyroid cancer
1499 (CTNNB1)
05217 Basal cell carcinoma
1499 (CTNNB1)
05215 Prostate cancer
1499 (CTNNB1)
05213 Endometrial cancer
1499 (CTNNB1)
05224 Breast cancer
1499 (CTNNB1)
09172 Infectious disease: viral
05160 Hepatitis C
1499 (CTNNB1)
05163 Human cytomegalovirus infection
1499 (CTNNB1)
05167 Kaposi sarcoma-associated herpesvirus infection
1499 (CTNNB1)
05165 Human papillomavirus infection
1499 (CTNNB1)
09171 Infectious disease: bacterial
05100 Bacterial invasion of epithelial cells
1499 (CTNNB1)
09164 Neurodegenerative disease
05010 Alzheimer disease
1499 (CTNNB1)
05022 Pathways of neurodegeneration - multiple diseases
1499 (CTNNB1)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
1499 (CTNNB1)
05412 Arrhythmogenic right ventricular cardiomyopathy
1499 (CTNNB1)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
1499 (CTNNB1)
04934 Cushing syndrome
1499 (CTNNB1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Arm
ARM_ARMC5
Cnd1
HEAT_2
HEAT_EZ
Adaptin_N
KAP
ARMC9_ARM
Atx10homo_assoc
Queuosine_synth
Motif
Other DBs
NCBI-GeneID:
1499
NCBI-ProteinID:
NP_001091679
OMIM:
116806
HGNC:
2514
Ensembl:
ENSG00000168036
UniProt:
P35222
Structure
PDB
PDBj
LinkDB
All DBs
Position
3:41199505..41240443
Genome browser
AA seq
781 aa
AA seq
DB search
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
NT seq
2346 nt
NT seq
+upstream
nt +downstream
nt
atggctactcaagctgatttgatggagttggacatggccatggaaccagacagaaaagcg
gctgttagtcactggcagcaacagtcttacctggactctggaatccattctggtgccact
accacagctccttctctgagtggtaaaggcaatcctgaggaagaggatgtggatacctcc
caagtcctgtatgagtgggaacagggattttctcagtccttcactcaagaacaagtagct
gatattgatggacagtatgcaatgactcgagctcagagggtacgagctgctatgttccct
gagacattagatgagggcatgcagatcccatctacacagtttgatgctgctcatcccact
aatgtccagcgtttggctgaaccatcacagatgctgaaacatgcagttgtaaacttgatt
aactatcaagatgatgcagaacttgccacacgtgcaatccctgaactgacaaaactgcta
aatgacgaggaccaggtggtggttaataaggctgcagttatggtccatcagctttctaaa
aaggaagcttccagacacgctatcatgcgttctcctcagatggtgtctgctattgtacgt
accatgcagaatacaaatgatgtagaaacagctcgttgtaccgctgggaccttgcataac
ctttcccatcatcgtgagggcttactggccatctttaagtctggaggcattcctgccctg
gtgaaaatgcttggttcaccagtggattctgtgttgttttatgccattacaactctccac
aaccttttattacatcaagaaggagctaaaatggcagtgcgtttagctggtgggctgcag
aaaatggttgccttgctcaacaaaacaaatgttaaattcttggctattacgacagactgc
cttcaaattttagcttatggcaaccaagaaagcaagctcatcatactggctagtggtgga
ccccaagctttagtaaatataatgaggacctatacttacgaaaaactactgtggaccaca
agcagagtgctgaaggtgctatctgtctgctctagtaataagccggctattgtagaagct
ggtggaatgcaagctttaggacttcacctgacagatccaagtcaacgtcttgttcagaac
tgtctttggactctcaggaatctttcagatgctgcaactaaacaggaagggatggaaggt
ctccttgggactcttgttcagcttctgggttcagatgatataaatgtggtcacctgtgca
gctggaattctttctaacctcacttgcaataattataagaacaagatgatggtctgccaa
gtgggtggtatagaggctcttgtgcgtactgtccttcgggctggtgacagggaagacatc
actgagcctgccatctgtgctcttcgtcatctgaccagccgacaccaagaagcagagatg
gcccagaatgcagttcgccttcactatggactaccagttgtggttaagctcttacaccca
ccatcccactggcctctgataaaggctactgttggattgattcgaaatcttgccctttgt
cccgcaaatcatgcacctttgcgtgagcagggtgccattccacgactagttcagttgctt
gttcgtgcacatcaggatacccagcgccgtacgtccatgggtgggacacagcagcaattt
gtggagggggtccgcatggaagaaatagttgaaggttgtaccggagcccttcacatccta
gctcgggatgttcacaaccgaattgttatcagaggactaaataccattccattgtttgtg
cagctgctttattctcccattgaaaacatccaaagagtagctgcaggggtcctctgtgaa
cttgctcaggacaaggaagctgcagaagctattgaagctgagggagccacagctcctctg
acagagttacttcactctaggaatgaaggtgtggcgacatatgcagctgctgttttgttc
cgaatgtctgaggacaagccacaagattacaagaaacggctttcagttgagctgaccagc
tctctcttcagaacagagccaatggcttggaatgagactgctgatcttggacttgatatt
ggtgcccagggagaaccccttggatatcgccaggatgatcctagctatcgttcttttcac
tctggtggatatggccaggatgccttgggtatggaccccatgatggaacatgagatgggt
ggccaccaccctggtgctgactatccagttgatgggctgccagatctggggcatgcccag
gacctcatggatgggctgcctccaggtgacagcaatcagctggcctggtttgatactgac
ctgtaa
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