Homo sapiens (human): 1719 Help Entry 1719              CDS       T01001                                  Symbol DHFR, DHFR1, DHFRP1, DYR Name (RefSeq) dihydrofolate reductase   KO K00287   dihydrofolate reductase [EC:1.5.1.3] Organism hsa  Homo sapiens (human) Pathway hsa00670   One carbon pool by folate hsa00790   Folate biosynthesis hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors hsa01523   Antifolate resistance hsa04981   Folate transport and metabolism Network nt06038  Folate metabolism   Element N01725   Tetrahydrofolate biosynthesis Disease H01197   Dihydrofolate reductase deficiency Drug target Edatrexate:  D03942 Methotrexate (DG00681):  D00142<JP/US> D02115<US> Pemetrexed (DG00682):  D03828<US> D06503<JP/US> D07472<US> D10596<JP/US> D11352<US> Piritrexim isethionate:  D05500 Pralatrexate:  D05589<JP/US> Talotrexin ammonium:  D05999 Trimetrexate (DG01013):  D06238 D06239 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09108 Metabolism of cofactors and vitamins    00790 Folate biosynthesis     1719 (DHFR)    00670 One carbon pool by folate     1719 (DHFR)  09150 Organismal Systems   09154 Digestive system    04981 Folate transport and metabolism     1719 (DHFR)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01523 Antifolate resistance     1719 (DHFR) Enzymes [BR:hsa01000]  1. Oxidoreductases   1.5  Acting on the CH-NH group of donors    1.5.1  With NAD+ or NADP+ as acceptor     1.5.1.3  dihydrofolate reductase      1719 (DHFR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DHFR_1 Motif Other DBs NCBI-GeneID:  1719 NCBI-ProteinID:  NP_000782 OMIM:  126060 HGNC:  2861 Ensembl:  ENSG00000228716 UniProt:  P00374 B0YJ76 Structure PDBPDBj LinkDB All DBs Position 5:complement(80626226..80654983) Genome browser AA seq 187 aa AA seqDB search MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF EVYEKND NT seq 564 nt NT seq  +upstreamnt  +downstreamnt atggttggttcgctaaactgcatcgtcgctgtgtcccagaacatgggcatcggcaagaac ggggacctgccctggccaccgctcaggaatgaattcagatatttccagagaatgaccaca acctcttcagtagaaggtaaacagaatctggtgattatgggtaagaagacctggttctcc attcctgagaagaatcgacctttaaagggtagaattaatttagttctcagcagagaactc aaggaacctccacaaggagctcattttctttccagaagtctagatgatgccttaaaactt actgaacaaccagaattagcaaataaagtagacatggtctggatagttggtggcagttct gtttataaggaagccatgaatcacccaggccatcttaaactatttgtgacaaggatcatg caagactttgaaagtgacacgttttttccagaaattgatttggagaaatataaacttctg ccagaatacccaggtgttctctctgatgtccaggaggagaaaggcattaagtacaaattt gaagtatatgagaagaatgattaa

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