Homo sapiens (human): 18 Help Entry 18                CDS       T01001                                  Symbol ABAT, GABA-AT, GABAT, NPD009 Name (RefSeq) 4-aminobutyrate aminotransferase   KO K13524   4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22] Organism hsa  Homo sapiens (human) Pathway hsa00250   Alanine, aspartate and glutamate metabolism hsa00280   Valine, leucine and isoleucine degradation hsa00410   beta-Alanine metabolism hsa00640   Propanoate metabolism hsa00650   Butanoate metabolism hsa01100   Metabolic pathways hsa04727   GABAergic synapse Module hsa_M00027   GABA (gamma-Aminobutyrate) shunt Network nt06544  Neuroactive ligand signaling   Element N01892   GABA metabolism and transport in glia Disease H01257   GABA-transaminase deficiency Drug target Valproic acid (DG00849):  D00304<US> D00399<US> D00710<JP/US> D08667 Vigabatrin:  D00535<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09101 Carbohydrate metabolism    00640 Propanoate metabolism     18 (ABAT)    00650 Butanoate metabolism     18 (ABAT)   09105 Amino acid metabolism    00250 Alanine, aspartate and glutamate metabolism     18 (ABAT)    00280 Valine, leucine and isoleucine degradation     18 (ABAT)   09106 Metabolism of other amino acids    00410 beta-Alanine metabolism     18 (ABAT)  09150 Organismal Systems   09156 Nervous system    04727 GABAergic synapse     18 (ABAT)  09180 Brite Hierarchies   09181 Protein families: metabolism    01007 Amino acid related enzymes [BR:hsa01007]     18 (ABAT) Enzymes [BR:hsa01000]  2. Transferases   2.6  Transferring nitrogenous groups    2.6.1  Transaminases     2.6.1.19  4-aminobutyrate---2-oxoglutarate transaminase      18 (ABAT)     2.6.1.22  (S)-3-amino-2-methylpropionate transaminase      18 (ABAT) Amino acid related enzymes [BR:hsa01007]  Aminotransferase (transaminase)   Class III    18 (ABAT) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Aminotran_3 Lenti_VIF_2 WH_RGF3 Motif Other DBs NCBI-GeneID:  18 NCBI-ProteinID:  NP_000654 OMIM:  137150 HGNC:  23 Ensembl:  ENSG00000183044 UniProt:  P80404 X5D8S1 LinkDB All DBs Position 16:8674617..8784570 Genome browser AA seq 500 aa AA seqDB search MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF RDHHAHLFLNIFSDILADFK NT seq 1503 nt NT seq  +upstreamnt  +downstreamnt atggcctccatgttgctcgcccagcgcctggcctgcagcttccagcacagctaccgcctg ctggtgcctggatccagacacattagtcaagctgcagccaaagtcgacgttgaatttgat tatgatgggcctctgatgaagacggaagtcccagggcctagatctcaggagttaatgaaa cagctgaatataattcagaatgcagaggctgtgcattttttctgcaattacgaagagagc cgaggcaattacctggttgatgtggacggcaaccgaatgctggatctttattcccagatc tcctctgtccccataggttacagccaccccgccctgctgaaactcatccaacagcctcaa aatgcgagcatgtttgtcaacagacccgccctcggaatcctgcctccggagaactttgtg gagaagctccggcagtccttgctctcggtggctcccaaagggatgtcccagctcatcacc atggcctgcggctcctgctccaatgaaaacgccttaaagaccatcttcatgtggtaccgg agcaaggaaagagggcagaggggcttctcccaggaggagctggagacgtgcatgattaac caggcccctggctgccccgactacagcatcctctccttcatgggcgcgttccatgggagg accatgggttgcttagcgaccacgcactctaaagccattcacaagatcgacatcccttcc tttgactggcccatcgcaccgttcccacggctgaaataccctctggaagagtttgtgaaa gagaaccaacaggaggaggcccgctgtctggaagaggtggaggatctgattgtgaaatat cggaaaaagaagaagacggtggccgggatcatcgtggagcccatccagtccgagggtgga gacaaccacgcatccgatgacttctttcggaagctgagagacatcgccaggaagcatggc tgcgccttcttggtggacgaggtccagaccggaggaggctgcacgggcaagttctgggcc catgagcactggggcctggatgacccagcagacgtgatgaccttcagcaagaagatgatg actgggggcttcttccacaaggaggagttcaggcctaatgctccctaccggatcttcaac acctggctgggggacccgtccaagaacctgttgctggctgaggtcatcaacatcatcaag cgggaggacctgctaaataatgcagcccatgccgggaaggccctgctcacaggactgctg gacctccaggcccggtacccccagttcatcagcagggtgagaggacgaggcaccttttgc tccttcgatactcccgatgattccatacggaataagctcattttaattgccagaaacaaa ggtgtggtgttgggtggctgtggtgacaaatccattcgtttccgtcccacgctggtcttc agggatcaccacgctcacctgttcctcaatattttcagtgacatcttagcagacttcaag taa

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