KEGG T01001: 3123

Homo sapiens (human): 3123

Entry

3123              CDS       T01001

Symbol

HLA-DRB1, DRB1, HLA-DR1B, HLA-DRB, SS1

Name

(RefSeq) major histocompatibility complex, class II, DR beta 1

K06752

MHC class II antigen

Organism

hsa Homo sapiens (human)

Pathway

hsa04145

Phagosome

hsa04514

Cell adhesion molecules

hsa04612

Antigen processing and presentation

hsa04640

Hematopoietic cell lineage

hsa04658

Th1 and Th2 cell differentiation

hsa04659

Th17 cell differentiation

hsa04672

Intestinal immune network for IgA production

hsa04940

Type I diabetes mellitus

hsa05140

Leishmaniasis

hsa05145

Toxoplasmosis

hsa05150

Staphylococcus aureus infection

hsa05152

Tuberculosis

hsa05164

Influenza A

hsa05166

Human T-cell leukemia virus 1 infection

hsa05168

Herpes simplex virus 1 infection

hsa05169

Epstein-Barr virus infection

hsa05310

Asthma

hsa05320

Autoimmune thyroid disease

hsa05321

Inflammatory bowel disease

hsa05322

Systemic lupus erythematosus

hsa05323

Rheumatoid arthritis

hsa05330

Allograft rejection

hsa05332

Graft-versus-host disease

hsa05416

Viral myocarditis

Network

nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06168 Herpes simplex virus 1 (HSV-1)

Element

N00508

HTLV-1 Tax to NFY-mediated transcription

N00590

Antigen processing and presentation by MHC class II molecules

Disease

H00079

Asthma

H00080

Systemic lupus erythematosus

H00294

Dilated cardiomyopathy

H00342

Tuberculosis

H00408

Type 1 diabetes mellitus

H00630

Rheumatoid arthritis

H01490

Multiple sclerosis

H01504

Vogt-Koyanagi-Harada syndrome

Drug target

Apolizumab:

D02967

Glatiramer acetate:

D04318<JP/US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    3123 (HLA-DRB1)
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3123 (HLA-DRB1)
   04612 Antigen processing and presentation
    3123 (HLA-DRB1)
   04658 Th1 and Th2 cell differentiation
    3123 (HLA-DRB1)
   04659 Th17 cell differentiation
    3123 (HLA-DRB1)
09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3123 (HLA-DRB1)
   05164 Influenza A
    3123 (HLA-DRB1)
   05169 Epstein-Barr virus infection
    3123 (HLA-DRB1)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    3123 (HLA-DRB1)
   05152 Tuberculosis
    3123 (HLA-DRB1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3123 (HLA-DRB1)
   05140 Leishmaniasis
    3123 (HLA-DRB1)
  09163 Immune disease
   05310 Asthma
    3123 (HLA-DRB1)
   05322 Systemic lupus erythematosus
    3123 (HLA-DRB1)
   05323 Rheumatoid arthritis
    3123 (HLA-DRB1)
   05320 Autoimmune thyroid disease
    3123 (HLA-DRB1)
   05321 Inflammatory bowel disease
    3123 (HLA-DRB1)
   05330 Allograft rejection
    3123 (HLA-DRB1)
   05332 Graft-versus-host disease
    3123 (HLA-DRB1)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    3123 (HLA-DRB1)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3123 (HLA-DRB1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3123 (HLA-DRB1)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3123 (HLA-DRB1)
  Exosomal proteins of epithelial cells
   3123 (HLA-DRB1)
  Exosomal proteins of breast milk
   3123 (HLA-DRB1)

SSDB

Motif

Pfam:

MHC_II_beta C1-set Ig_3 ig Ig_2 C2-set_2 I-set DUF202

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

6:complement(32578775..32589848)

AA seq 266 aa
MVCLRLPGGSCMAVLTVTLMVLSSPLALAGDTRPRFLEYSTSECHFFNGTERVRYLDRYF
HNQEENVRFDSDVGEFRAVTELGRPDAEYWNSQKDLLEQKRGRVDNYCRHNYGVVESFTV
QRRVHPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKTGVVSTGLIHNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL
FLGAGLFIYFRNQKGHSGLQPRGFLS

NT seq 801 nt +upstreamnt +downstreamnt
atggtgtgtctgaggctccctggaggctcctgcatggcagttctgacagtgacactgatg
gtgctgagctccccactggctttggctggggacaccagaccacgtttcttggagtactct
acgtctgagtgtcatttcttcaatgggacggagcgggtgcggtacctggacagatacttc
cataaccaggaggagaacgtgcgcttcgacagcgacgtgggggagttccgggcggtgacg
gagctggggcggcctgatgccgagtactggaacagccagaaggacctcctggagcagaag
cggggccgggtggacaactactgcagacacaactacggggttgtggagagcttcacagtg
cagcggcgagtccatcctaaggtgactgtgtatccttcaaagacccagcccctgcagcac
cataacctcctggtctgttctgtgagtggtttctatccaggcagcattgaagtcaggtgg
ttccggaatggccaggaagagaagactggggtggtgtccacaggcctgatccacaatgga
gactggaccttccagaccctggtgatgctggaaacagttcctcggagtggagaggtttac
acctgccaagtggagcacccaagcgtgacaagccctctcacagtggaatggagagcacgg
tctgaatctgcacagagcaagatgctgagtggagtcgggggctttgtgctgggcctgctc
ttccttggggccgggctgttcatctacttcaggaatcagaaaggacactctggacttcag
ccaagaggattcctgagctga

DBGET integrated database retrieval system