Homo sapiens (human): 4855
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Entry
4855 CDS
T01001
Symbol
NOTCH4, INT3
Name
(RefSeq) notch receptor 4
KO
K20996
Notch 4
Organism
hsa
Homo sapiens (human)
Pathway
hsa01522
Endocrine resistance
hsa04330
Notch signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa05165
Human papillomavirus infection
hsa05200
Pathways in cancer
hsa05206
MicroRNAs in cancer
hsa05224
Breast cancer
Network
nt06166
Human papillomavirus (HPV)
nt06216
NOTCH signaling (cancer)
nt06270
Breast cancer
nt06465
Prion disease
nt06511
NOTCH signaling
Element
N00086
Notch signaling pathway
N00087
NOTCH-overexpression to Notch signaling pathway
N00380
HPV E6 to Notch signaling pathway
N00381
HPV E6 to Notch signaling pathway
N00382
HPV E6 to Notch signaling pathway
N01478
Notch proteolytic activation
Disease
H00031
Breast cancer
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
4855 (NOTCH4)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
4855 (NOTCH4)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
4855 (NOTCH4)
05206 MicroRNAs in cancer
4855 (NOTCH4)
09162 Cancer: specific types
05224 Breast cancer
4855 (NOTCH4)
09172 Infectious disease: viral
05165 Human papillomavirus infection
4855 (NOTCH4)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
4855 (NOTCH4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
EGF
hEGF
EGF_TEN
Ank
EGF_CA
Ank_2
Notch
Ank_3
Ank_4
Ank_5
EGF_3
NODP
EGF_2
NOD
EGF_Teneurin
Motif
Other DBs
NCBI-GeneID:
4855
NCBI-ProteinID:
NP_004548
OMIM:
164951
HGNC:
7884
Ensembl:
ENSG00000204301
UniProt:
Q99466
A0A1U9X983
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:complement(32194843..32224067)
Genome browser
AA seq
2003 aa
AA seq
DB search
MQPPSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGE
TCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLED
PCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQC
HCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPP
RGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTC
LCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCI
AATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLC
QPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECL
SQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICL
PGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPV
GASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAP
PEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTG
YTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGG
TCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGS
CQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSL
CHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGY
DGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGT
AACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFE
GPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPC
LYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDG
GDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCH
DHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPSLALLVVLSPPALDQQLFALARVLS
LTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPTYQERAAPQTQPLGKETDSLSAG
FVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHAGTAP
PANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRR
RPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLWSLSGGCGA
LPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEPLL
DGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAR
EVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHW
AAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAG
LAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGALPR
CRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGM
RGPRPNPAIMRGRYGVAAGRGGRVSTDDWPCDWVALGACGSASNIPIPPPCLTPSPERGS
PQLDCGPPALQEMPINQGGEGKK
NT seq
6012 nt
NT seq
+upstream
nt +downstream
nt
atgcagcccccttcactgctgctgctgctgctgctgctgctgctgctatgtgtctcagtg
gtcagacccagagggctgctgtgtgggagtttcccagaaccctgtgccaatggaggcacc
tgcctgagcctgtctctgggacaagggacctgccagtgtgcccctggcttcctgggtgag
acgtgccagtttcctgacccctgccagaacgcccagctctgccaaaatggaggcagctgc
caagccctgcttcccgctcccctagggctccccagctctccctctccattgacacccagc
ttcttgtgcacttgcctccctggcttcactggtgagagatgccaggccaagcttgaagac
ccttgtcctccctccttctgttccaaaaggggccgctgccacatccaggcctcgggccgc
ccacagtgctcctgcatgcctggatggacaggtgagcagtgccagcttcgggacttctgt
tcagccaacccatgtgttaatggaggggtgtgtctggccacatacccccagatccagtgc
cactgcccaccgggcttcgagggccatgcctgtgaacgtgatgtcaacgagtgcttccag
gacccaggaccctgccccaaaggcacctcctgccataacaccctgggctccttccagtgc
ctctgccctgtggggcaggagggtccacgttgtgagctgcgggcaggaccctgccctcct
aggggctgttcgaatgggggcacctgccagctgatgccagagaaagactccacctttcac
ctctgcctctgtcccccaggtttcataggcccagactgtgaggtgaatccagacaactgt
gtcagccaccagtgtcagaatgggggcacttgccaggatgggctggacacctacacctgc
ctctgcccagaaacctggacaggctgggactgctccgaagatgtggatgagtgtgagacc
cagggtccccctcactgcagaaacgggggcacctgccagaactctgctggtagctttcac
tgcgtgtgtgtgagtggctggggcggcacaagctgtgaggagaacctggatgactgtatt
gctgccacctgtgccccgggatccacctgcattgaccgggtgggctctttctcctgcctc
tgcccacctggacgcacaggactcctgtgccacttggaagacatgtgtctgagccagccg
tgccatggggatgcccaatgcagcaccaaccccctcacaggctccacactctgcctgtgt
cagcctggctattcggggcccacctgccaccaggacctggacgagtgtctgatggcccag
caaggcccaagtccctgtgaacatggcggttcctgcctcaacactcctggctccttcaac
tgcctctgtccacctggctacacaggctcccgttgtgaggctgatcacaatgagtgcctc
tcccagccctgccacccaggaagcacctgtctggacctacttgccaccttccactgcctc
tgcccgccaggcttagaagggcagctctgtgaggtggagaccaacgagtgtgcctcagct
ccctgcctgaaccacgcggattgccatgacctgctcaacggcttccagtgcatctgcctg
cctggattctccggcacccgatgtgaggaggatatcgatgagtgcagaagctctccctgt
gccaatggtgggcagtgccaggaccagcctggagccttccactgcaagtgtctcccaggc
tttgaagggccacgctgtcaaacagaggtggatgagtgcctgagtgacccatgtcccgtt
ggagccagctgccttgatcttccaggagccttcttttgcctctgcccctctggtttcaca
ggccagctctgtgaggttcccctgtgtgctcccaacctgtgccagcccaagcagatatgt
aaggaccagaaagacaaggccaactgcctctgtcctgatggaagccctggctgtgcccca
cctgaggacaactgcacctgccaccacgggcactgccagagatcctcatgtgtgtgtgac
gtgggttggacggggccagagtgtgaggcagagctagggggctgcatctctgcaccctgt
gcccatggggggacctgctacccccagccctctggctacaactgcacctgccctacaggc
tacacaggacccacctgtagtgaggagatgacagcttgtcactcagggccatgtctcaat
ggcggctcctgcaaccctagccctggaggctactactgcacctgccctccaagccacaca
gggccccagtgccaaaccagcactgactactgtgtgtctgccccgtgcttcaatgggggt
acctgtgtgaacaggcctggcaccttctcctgcctctgtgccatgggcttccagggcccg
cgctgtgagggaaagctccgccccagctgtgcagacagcccctgtaggaatagggcaacc
tgccaggacagccctcagggtccccgctgcctctgccccactggctacaccggaggcagc
tgccagactctgatggacttatgtgcccagaagccctgcccacgcaattcccactgcctc
cagactgggccctccttccactgcttgtgcctccagggatggaccgggcctctctgcaac
cttccactgtcctcctgccagaaggctgcactgagccaaggcatagacgtctcttccctt
tgccacaatggaggcctctgtgtcgacagcggcccctcctatttctgccactgcccccct
ggattccaaggcagcctgtgccaggatcacgtgaacccatgtgagtccaggccttgccag
aacggggccacctgcatggcccagcccagtgggtatctctgccagtgtgccccaggctac
gatggacagaactgctcaaaggaactcgatgcttgtcagtcccaaccctgtcacaaccat
ggaacctgtactcccaaacctggaggattccactgtgcctgccctccaggctttgtgggg
ctacgctgtgagggagacgtggacgagtgtctggaccagccctgccaccccacaggcact
gcagcctgccactctctggccaatgccttctactgccagtgtctgcctggacacacaggc
cagtggtgtgaggtggagatagacccctgccacagccaaccctgctttcatggagggacc
tgtgaggccacagcaggatcacccctgggtttcatctgccactgccccaagggttttgaa
ggccccacctgcagccacagggccccttcctgcggcttccatcactgccaccacggaggc
ctgtgtctgccctcccctaagccaggcttcccaccacgctgtgcctgcctcagtggctat
gggggtcctgactgcctgaccccaccagctcctaaaggctgtggccctccctccccatgc
ctatacaatggcagctgctcagagaccacgggcttggggggcccaggctttcgatgctcc
tgccctcacagctctccagggccccggtgtcagaaacccggagccaaggggtgtgagggc
agaagtggagatggggcctgcgatgctggctgcagtggcccgggaggaaactgggatgga
ggggactgctctctgggagtcccagacccctggaagggctgcccctcccactctcggtgc
tggcttctcttccgggacgggcagtgccacccacagtgtgactctgaagagtgtctgttt
gatggctacgactgtgagacccctccagcctgcactccagcctatgaccagtactgccat
gatcacttccacaacgggcactgtgagaaaggctgcaacactgcagagtgtggctgggat
ggaggtgactgcaggcctgaagatggggacccagagtgggggccctccctggccctgctg
gtggtactgagccccccagccctagaccagcagctgtttgccctggcccgggtgctgtcc
ctgactctgagggtaggactctgggtaaggaaggatcgtgatggcagggacatggtgtac
ccctatcctggggcccgggctgaagaaaagctaggaggaactcgggaccccacctatcag
gagagagcagcccctcaaacgcagcccctgggcaaggagaccgactccctcagtgctggg
tttgtggtggtcatgggtgtggatttgtcccgctgtggccctgaccacccggcatcccgc
tgtccctgggaccctgggcttctactccgcttccttgctgcgatggctgcagtgggagcc
ctggagcccctgctgcctggaccactgctggctgtccaccctcatgcagggaccgcaccc
cctgccaaccagcttccctggcctgtgctgtgctccccagtggccggggtgattctcctg
gccctaggggctcttctcgtcctccagctcatccggcgtcgacgccgagagcatggagct
ctctggctgccccctggtttcactcgacggcctcggactcagtcagctccccaccgacgc
cggcccccactaggcgaggacagcattggtctcaaggcactgaagccaaaggcagaagtt
gatgaggatggagttgtgatgtgctcaggccctgaggagggagaggaggtgggccaggct
gaagaaacaggcccaccctccacgtgccagctctggtctctgagtggtggctgtggggcg
ctccctcaggcagccatgctaactcctccccaggaatctgagatggaagcccctgacctg
gacacccgtggacctgatggggtgacacccctgatgtcagcagtttgctgtggggaagta
cagtccgggaccttccaaggggcatggttgggatgtcctgagccctgggaacctctgctg
gatggaggggcctgtccccaggctcacaccgtgggcactggggagacccccctgcacctg
gctgcccgattctcccggccaaccgctgcccgccgcctccttgaggctggagccaacccc
aaccagccagaccgggcagggcgcacaccccttcatgctgctgtggctgctgatgctcgg
gaggtctgccagcttctgctccgtagcagacaaactgcagtggacgctcgcacagaggac
gggaccacacccttgatgctggctgccaggctggcggtggaagacctggttgaagaactg
attgcagcccaagcagacgtgggggccagagataaatgggggaaaactgcgctgcactgg
gctgctgccgtgaacaacgcccgagccgcccgctcgcttctccaggccggagccgataaa
gatgcccaggacaacagggagcagacgccgctattcctggcggcgcgggaaggagcggtg
gaagtagcccagctactgctggggctgggggcagcccgagagctgcgggaccaggctggg
ctagcgccggcggacgtcgctcaccaacgtaaccactgggatctgctgacgctgctggaa
ggggctgggccaccagaggcccgtcacaaagccacgccgggccgcgaggctgggcccttc
ccgcgcgcacggacggtgtcagtaagcgtgcccccgcatgggggcggggctctgccgcgc
tgccggacgctgtcagccggagcaggccctcgtgggggcggagcttgtctgcaggctcgg
acttggtccgtagacttggctgcgcgggggggcggggcctattctcattgccggagcctc
tcgggagtaggagcaggaggaggcccgacccctcgcggccgtaggttttctgcaggcatg
cgcgggcctcggcccaaccctgcgataatgcgaggaagatacggagtggctgccgggcgc
ggaggcagggtctcaacggatgactggccctgtgattgggtggccctgggagcttgcggt
tctgcctccaacattccgatcccgcctccttgccttactccgtccccggagcggggatca
cctcaacttgactgtggtcccccagccctccaagaaatgcccataaaccaaggaggagag
ggtaaaaaatag
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