KEGG T01001: 5925

Homo sapiens (human): 5925

Entry

5925              CDS       T01001

Symbol

RB1, OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb, pp110

Name

(RefSeq) RB transcriptional corepressor 1

K06618

retinoblastoma-associated protein

Organism

hsa Homo sapiens (human)

Pathway

hsa01522

Endocrine resistance

hsa04110

Cell cycle

hsa04218

Cellular senescence

hsa04934

Cushing syndrome

hsa05160

Hepatitis C

hsa05161

Hepatitis B

hsa05163

Human cytomegalovirus infection

hsa05165

Human papillomavirus infection

hsa05166

Human T-cell leukemia virus 1 infection

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05169

Epstein-Barr virus infection

hsa05200

Pathways in cancer

hsa05203

Viral carcinogenesis

hsa05207

Chemical carcinogenesis - receptor activation

hsa05212

Pancreatic cancer

hsa05214

Glioma

hsa05215

Prostate cancer

hsa05218

Melanoma

hsa05219

Bladder cancer

hsa05220

Chronic myeloid leukemia

hsa05222

Small cell lung cancer

hsa05223

Non-small cell lung cancer

hsa05224

Breast cancer

hsa05225

Hepatocellular carcinoma

hsa05226

Gastric cancer

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06230  Cell cycle (cancer)
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
nt06360  Cushing syndrome

Element

N00066

MDM2-p21-Cell cycle G1/S

N00067

Deleted p14(ARF) to p21-cell cycle G1/S

N00068

Amplified MDM2 to p21-cell cycle G1/S

N00069

p16-Cell cycle G1/S

N00070

Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S

N00071

Deleted p16(INK4a) to p16-cell cycle G1/S

N00072

Amplified CDK4 to cell cycle G1/S

N00073

Mutation-activated CDK4 to cell cycle G1/S

N00074

Loss of RB1 to cell cycle G1/S

N00075

Mutation-inactivated RB1 to cell cycle G1/S

N00076

Mutation-inactivated p14(ARF) to p21-cell cycle G1/S

N00088

Amplified MYC to p15-cell cycle G1/S

N00089

Amplified MYC to cell cycle G1/S

N00090

p15-Cell cycle G1/S

N00091

p27-Cell cycle G1/S

N00092

Amplified MYC to p27-cell cycle G1/S

N00093

Loss of CDKN1B to p27-cell cycle G1/S

N00168

KSHV vCyclin to cell cycle G1/S

N00170

KSHV LANA to cell cycle G1/S

N00254

CDKN1B-reduced expression to p27-cell cycle G1/S

N00255

Amplified CCNE to cell cycle G1/S

N00264

EBV EBNA3C to p27-Cell cycle G1/S

N00275

Amplified CCND1 to cell cycle G1/S

N00316

Mutation-inactivated CDKN1B to p27-cell cycle G1/S

N00347

p300-p21-Cell cycle G1/S

N00360

HPV E7 to p27-cell cycle G1/S

N00361

HPV E7 to cell cycle G1/S

N00365

HPV E7 to cell cycle G1/S

N00422

HCMV IE2-86 to cell cycle G1/S

N00423

HCMV IE1-72 to cell cycle G1/S

N00424

HCMV pp71 to cell cycle G1/S

N00482

EBV EBNA3C to p27-Cell cycle G1/S

N00483

EBV EBNA3C to cell cycle G1/S

N00484

EBV EBNA3C to cell cycle G1/S

N00497

HTLV-1 Tax to p21-cell cycle G1/S

N00498

HTLV-1 Tax to p21-cell cycle G1/S

N00536

MDM2-p21-Cell cycle G1/S

N00537

HBV HBx to cell cycle G1/S

N01336

CHRNA7-E2F signaling pathway

N01337

NNK/NNN to CHRNA7-E2F signaling pathway

Disease

H00004

Chronic myeloid leukemia

H00013

Small cell lung cancer

H00017

Esophageal cancer

H00022

Bladder cancer

H00036

Osteosarcoma

H00042

Glioma

H00048

Hepatocellular carcinoma

H01513

Retinoblastoma

Brite

KEGG Orthology (KO) [BR:hsa00001]
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5925 (RB1)
   05207 Chemical carcinogenesis - receptor activation
    5925 (RB1)
   05203 Viral carcinogenesis
    5925 (RB1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    5925 (RB1)
   05225 Hepatocellular carcinoma
    5925 (RB1)
   05226 Gastric cancer
    5925 (RB1)
   05214 Glioma
    5925 (RB1)
   05220 Chronic myeloid leukemia
    5925 (RB1)
   05218 Melanoma
    5925 (RB1)
   05219 Bladder cancer
    5925 (RB1)
   05215 Prostate cancer
    5925 (RB1)
   05224 Breast cancer
    5925 (RB1)
   05222 Small cell lung cancer
    5925 (RB1)
   05223 Non-small cell lung cancer
    5925 (RB1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5925 (RB1)
   05161 Hepatitis B
    5925 (RB1)
   05160 Hepatitis C
    5925 (RB1)
   05163 Human cytomegalovirus infection
    5925 (RB1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5925 (RB1)
   05169 Epstein-Barr virus infection
    5925 (RB1)
   05165 Human papillomavirus infection
    5925 (RB1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    5925 (RB1)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    5925 (RB1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5925 (RB1)
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    5925 (RB1)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     5925 (RB1)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Other transcription factors
   Pocket domain Rb
    5925 (RB1)

SSDB

Motif

Pfam:

Rb_C RB_A RB_B DUF3452 TFIIB

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

13:48303751..48481890

AA seq 928 aa
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTAL
CQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTEL
QKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS
ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYK
TAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFM
NSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS
NLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVK
DIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDN
IFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEG
NLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNH
TAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYL
RLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLK
FKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLS
PIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFG
TSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQK
LAEMTSTRTRMQKQKMNDSMDTSNKEEK

NT seq 2787 nt +upstreamnt +downstreamnt
atgccgcccaaaaccccccgaaaaacggccgccaccgccgccgctgccgccgcggaaccc
ccggcaccgccgccgccgccccctcctgaggaggacccagagcaggacagcggcccggag
gacctgcctctcgtcaggcttgagtttgaagaaacagaagaacctgattttactgcatta
tgtcagaaattaaagataccagatcatgtcagagagagagcttggttaacttgggagaaa
gtttcatctgtggatggagtattgggaggttatattcaaaagaaaaaggaactgtgggga
atctgtatctttattgcagcagttgacctagatgagatgtcgttcacttttactgagcta
cagaaaaacatagaaatcagtgtccataaattctttaacttactaaaagaaattgatacc
agtaccaaagttgataatgctatgtcaagactgttgaagaagtatgatgtattgtttgca
ctcttcagcaaattggaaaggacatgtgaacttatatatttgacacaacccagcagttcg
atatctactgaaataaattctgcattggtgctaaaagtttcttggatcacatttttatta
gctaaaggggaagtattacaaatggaagatgatctggtgatttcatttcagttaatgcta
tgtgtccttgactattttattaaactctcacctcccatgttgctcaaagaaccatataaa
acagctgttatacccattaatggttcacctcgaacacccaggcgaggtcagaacaggagt
gcacggatagcaaaacaactagaaaatgatacaagaattattgaagttctctgtaaagaa
catgaatgtaatatagatgaggtgaaaaatgtttatttcaaaaattttataccttttatg
aattctcttggacttgtaacatctaatggacttccagaggttgaaaatctttctaaacga
tacgaagaaatttatcttaaaaataaagatctagatgcaagattatttttggatcatgat
aaaactcttcagactgattctatagacagttttgaaacacagagaacaccacgaaaaagt
aaccttgatgaagaggtgaatgtaattcctccacacactccagttaggactgttatgaac
actatccaacaattaatgatgattttaaattcagcaagtgatcaaccttcagaaaatctg
atttcctattttaacaactgcacagtgaatccaaaagaaagtatactgaaaagagtgaag
gatataggatacatctttaaagagaaatttgctaaagctgtgggacagggttgtgtcgaa
attggatcacagcgatacaaacttggagttcgcttgtattaccgagtaatggaatccatg
cttaaatcagaagaagaacgattatccattcaaaattttagcaaacttctgaatgacaac
atttttcatatgtctttattggcgtgcgctcttgaggttgtaatggccacatatagcaga
agtacatctcagaatcttgattctggaacagatttgtctttcccatggattctgaatgtg
cttaatttaaaagcctttgatttttacaaagtgatcgaaagttttatcaaagcagaaggc
aacttgacaagagaaatgataaaacatttagaacgatgtgaacatcgaatcatggaatcc
cttgcatggctctcagattcacctttatttgatcttattaaacaatcaaaggaccgagaa
ggaccaactgatcaccttgaatctgcttgtcctcttaatcttcctctccagaataatcac
actgcagcagatatgtatctttctcctgtaagatctccaaagaaaaaaggttcaactacg
cgtgtaaattctactgcaaatgcagagacacaagcaacctcagccttccagacccagaag
ccattgaaatctacctctctttcactgttttataaaaaagtgtatcggctagcctatctc
cggctaaatacactttgtgaacgccttctgtctgagcacccagaattagaacatatcatc
tggacccttttccagcacaccctgcagaatgagtatgaactcatgagagacaggcatttg
gaccaaattatgatgtgttccatgtatggcatatgcaaagtgaagaatatagaccttaaa
ttcaaaatcattgtaacagcatacaaggatcttcctcatgctgttcaggagacattcaaa
cgtgttttgatcaaagaagaggagtatgattctattatagtattctataactcggtcttc
atgcagagactgaaaacaaatattttgcagtatgcttccaccaggccccctaccttgtca
ccaatacctcacattcctcgaagcccttacaagtttcctagttcacccttacggattcct
ggagggaacatctatatttcacccctgaagagtccatataaaatttcagaaggtctgcca
acaccaacaaaaatgactccaagatcaagaatcttagtatcaattggtgaatcattcggg
acttctgagaagttccagaaaataaatcagatggtatgtaacagcgaccgtgtgctcaaa
agaagtgctgaaggaagcaaccctcctaaaccactgaaaaaactacgctttgatattgaa
ggatcagatgaagcagatggaagtaaacatctcccaggagagtccaaatttcagcagaaa
ctggcagaaatgacttctactcgaacacgaatgcaaaagcagaaaatgaatgatagcatg
gatacctcaaacaaggaagagaaatga

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