Homo sapiens (human): 7468
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Entry
7468 CDS
T01001
Symbol
NSD2, KMT3F, KMT3G, MMSET, RAUST, REIIBP, TRX5, WHS, WHSC1
Name
(RefSeq) nuclear receptor binding SET domain protein 2
KO
K11424
[histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:
2.1.1.357
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00310
Lysine degradation
hsa01100
Metabolic pathways
hsa05202
Transcriptional misregulation in cancer
Network
nt06240
Transcription (cancer)
Element
N00125
IGH-MMSET fusion to transcriptional activation
Disease
H00010
Multiple myeloma
H01773
4p deletion syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
7468 (NSD2)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
7468 (NSD2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
7468 (NSD2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.357 [histone H3]-lysine36 N-dimethyltransferase
7468 (NSD2)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
7468 (NSD2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PWWP
PHD-1st_NSD
SET
PHD_NSD
AWS
C5HCH
PHD
HMG_box
PHDvar_NSD
HMG_box_2
zf-HC5HC2H
zf-HC5HC2H_2
MUM1-like_PWWP
HMG_WDHD1
Motif
Other DBs
NCBI-GeneID:
7468
NCBI-ProteinID:
NP_001035889
OMIM:
602952
HGNC:
12766
Ensembl:
ENSG00000109685
UniProt:
O96028
Structure
PDB
PDBj
LinkDB
All DBs
Position
4:1871393..1982192
Genome browser
AA seq
1365 aa
AA seq
DB search
MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEG
VMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNG
SPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLE
QGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMV
SADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQ
APTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVA
KEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGK
STPQKTAEADPRRGVGSPPGRKKTTVSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDASG
EEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAE
AEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKR
NRASTAASSALGFSKSSSPSASLTENEVSDSPGDEPSESPYESADETQTEVSVSSKKSER
GVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVC
KESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKG
KMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKG
GSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCH
PKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKN
ALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKP
TDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAK
RDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFM
NHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSG
FLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCT
KAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGR
SYCCEHDLGAASVRSTKTEKPPPEPGKPKGKRRRRRGWRRVTEGK
NT seq
4098 nt
NT seq
+upstream
nt +downstream
nt
atggaatttagcatcaagcagagtcccctttctgttcagagtgttgtaaagtgcataaag
atgaagcaggcaccagaaatcctcggcagtgccaacgggaagactccgagctgcgaggtg
aaccgcgagtgttctgtgttcctcagcaaagcccagctctccagtagcctgcaggagggg
gtcatgcagaagtttaacggccacgacgccctgccctttattccagccgacaagctgaaa
gatcttacttcccgggtgtttaatggagaacccggcgcacacgatgccaaactgcgtttt
gagtcccaggaaatgaaagggattgggacaccccctaacactacccctatcaaaaatggc
tctccagaaattaagctgaaaatcaccaaaacatacatgaatgggaagcctctctttgaa
tcttccatttgtggtgacagtgctgctgatgtgtctcagtcagaagaaaatggacaaaaa
ccagaaaacaaggcgagaaggaacaggaagaggagcataaaatatgactccttgctggag
cagggccttgtcgaagcagctcttgtgtctaagatctcaagtccttcagataaaaagatt
ccagctaagaaagagtcttgtccaaacactggaagagacaaagaccacctgttgaaatac
aacgttggtgatttggtgtggtccaaagtgtcgggttacccttggtggccttgcatggtt
tctgcagatccactccttcacagctataccaaacttaaaggtcagaaaaagagtgcacgc
cagtatcacgtacagttctttggtgacgccccagaaagagcttggatatttgagaagagc
ctcgtagcttttgaaggagaaggacagtttgaaaaattatgccaggaaagtgccaagcag
gcacccacgaaagctgagaaaattaagctattgaaaccaatttcagggaaattgagggcc
cagtgggaaatgggcattgttcaagcagaagaagctgcaagcatgtcagtggaggagcgg
aaagccaagttcacctttctctatgtgggggaccagcttcatctcaaccctcaagtagcc
aaggaggctggcattgctgcagagtctttgggagaaatggcagaatcctcaggagtcagt
gaagaagctgctgaaaaccccaagtctgtgagagaagagtgcattcccatgaagagaagg
cggagggccaaactgtgtagctctgcagagaccctggagagtcaccccgacatagggaag
agtactcctcaaaagacggcagaggctgaccccagaagaggagtagggtctcctcctggg
aggaagaagaccacagtctccatgccacgaagcaggaagggagatgcagcatcccagttt
ttggtcttctgtcaaaaacacagggatgaggtggtagctgagcacccagatgcttcaggt
gaggagattgaagagctgctcaggtcacagtggagtctgctgagtgagaagcagagagca
cgctacaacaccaagtttgccctggtggcccctgtccaggctgaagaagactctggtaat
gtaaatgggaaaaaaagaaaccacacaaagaggatacaggaccctacagaagatgctgaa
gctgaggacacacccaggaaaagactcaggacggacaagcacagtcttcggaagagagac
acaatcactgacaaaacggccagaacaagctcttacaaggccatggaggcagcctcctcg
ctcaagagccaggcagcaacgaaaaatctgtctgatgcatgtaaaccactgaagaagcga
aatcgggcttccacggcagcatcttcagctcttgggtttagcaaaagttcatctccttct
gcatccttaactgagaatgaggtctcggacagcccgggagacgagccctcggagtcccca
tacgaaagtgcagacgaaacacaaactgaagtatctgtctcatccaaaaagtctgagcga
ggagtgactgccaaaaaggagtatgtgtgccagctgtgtgagaagccgggcagcctcctg
ctctgtgaaggaccctgctgcggagctttccacctcgcctgccttgggctttcccggagg
ccagaagggaggttcacctgcagcgagtgtgcctcagggattcactcatgtttcgtgtgt
aaagagagcaagacagatgttaagcgctgtgtggtaactcagtgtggaaaattttaccat
gaggcttgtgtgaaaaaataccctctgactgtatttgagagccgaggtttccgctgcccc
ctccacagctgtgtgagctgccatgcttccaacccttcaaacccaaggccgtcaaaaggt
aaaatgatgcggtgtgtccgctgccccgttgcctatcacagcggggatgcttgtctggca
gcaggatgctcagtgatcgcctccaacagcatcatctgcactgcccacttcactgctcgg
aaggggaagcgacaccacgcccacgtcaacgtgagctggtgcttcgtgtgctccaaaggg
gggagccttctgtgctgtgagtcctgcccagcggccttccaccctgactgcctgaacatc
gagatgcctgacggcagctggttctgcaatgactgcagggctgggaagaagctgcacttc
caggatatcatttgggtgaaacttgggaactacagatggtggccggcagaagtttgccat
cccaaaaatgttcccccaaatattcagaaaatgaagcacgagattggagaattccctgtg
tttttctttgggtctaaagattattactggacgcatcaggcgcgagtgttcccgtacatg
gagggggaccggggcagccgctaccagggggtcagagggatcggaagagtcttcaaaaac
gcactgcaagaagctgaagctcgttttcgtgaaattaagcttcagagggaagcccgagaa
acacaggagagcgagcgcaagcccccaccatacaagcacatcaaggtgaataagccttac
gggaaagtccagatctacacagcggatatttcagaaatccctaagtgcaactgcaagccc
acagatgagaatccttgtggctttgattcggagtgtctgaacaggatgctgatgtttgag
tgccacccgcaggtgtgtcccgcgggcgagttctgccagaaccagtgcttcaccaagcgc
cagtacccagagaccaagatcatcaagacagatggcaaagggtggggcctggtcgccaag
agggacatcagaaagggagaatttgttaacgagtacgttggggagctgatcgacgaggag
gagtgcatggcgagaatcaagcacgcacacgagaacgacatcacccacttctacatgctc
actatagacaaggaccgtataatagacgctggccccaaaggaaactactctcgatttatg
aatcacagctgccagcccaactgtgagaccctcaagtggacagtgaatggggacactcgt
gtgggcctgtttgccgtctgtgacattcctgcagggacggagctgacttttaactacaac
ctcgattgtctgggcaatgaaaaaacggtctgccggtgtggagcctccaattgcagtgga
ttcctcggggatagaccaaagacctcgacgaccctttcatcagaggaaaagggcaaaaag
accaagaagaaaacgaggcggcgcagagcaaaaggggaagggaagaggcagtcagaggac
gagtgcttccgctgcggtgatggcgggcagctggtgctgtgtgaccgcaagttctgcacc
aaggcctaccacctgtcctgcctgggccttggcaagcggcccttcgggaagtgggaatgt
ccttggcatcattgtgacgtgtgtggcaaaccttcgacttcattttgccacctctgcccc
aattcgttctgtaaggagcaccaggacgggacagccttcagctgcaccccggacgggcgg
tcctactgctgtgagcatgacttaggggcggcatcggtcagaagcaccaagactgagaag
ccccccccagagccagggaagccgaaggggaagaggcggcggcggaggggctggcggaga
gtcacagagggcaaatag
DBGET
integrated database retrieval system
