Homo sapiens (human): 8549
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Entry
8549 CDS
T01001
Symbol
LGR5, FEX, GPR49, GPR67, GRP49, HG38
Name
(RefSeq) leucine rich repeat containing G protein-coupled receptor 5
KO
K04308
leucine-rich repeat-containing G protein-coupled receptor 5
Organism
hsa
Homo sapiens (human)
Pathway
hsa04310
Wnt signaling pathway
Network
nt06505
WNT signaling
Element
N01440
Wnt signaling modulation, LGR/RSPO
Drug target
Petosemtamab:
D12416
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
8549 (LGR5)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
8549 (LGR5)
G protein-coupled receptors [BR:
hsa04030
]
Rhodopsin family
Others
R-spondin
8549 (LGR5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
LRR_8
LRR_4
LRR_5
LRR_1
LRR_14
LRR_9
7tm_1
LRR_LRWD1
LRRNT
LRR_EndoS
LRR_R13L1-DRL21
Motif
Other DBs
NCBI-GeneID:
8549
NCBI-ProteinID:
NP_003658
OMIM:
606667
HGNC:
4504
Ensembl:
ENSG00000139292
UniProt:
O75473
A0A0A8K8C7
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:71439129..71586310
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AA seq
907 aa
AA seq
DB search
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSEL
PSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLM
LQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQ
AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLD
LNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSA
FQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLS
YNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFST
LPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCC
AFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQ
CSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIA
AVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAAL
ERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEP
STMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNC
PVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYV
WTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSS
VAFVPCL
NT seq
2724 nt
NT seq
+upstream
nt +downstream
nt
atggacacctcccggctcggtgtgctcctgtccttgcctgtgctgctgcagctggcgacc
gggggcagctctcccaggtctggtgtgttgctgaggggctgccccacacactgtcattgc
gagcccgacggcaggatgttgctcagggtggactgctccgacctggggctctcggagctg
ccttccaacctcagcgtcttcacctcctacctagacctcagtatgaacaacatcagtcag
ctgctcccgaatcccctgcccagtctccgcttcctggaggagttacgtcttgcgggaaac
gctctgacatacattcccaagggagcattcactggcctttacagtcttaaagttcttatg
ctgcagaataatcagctaagacacgtacccacagaagctctgcagaatttgcgaagcctt
caatccctgcgtctggatgctaaccacatcagctatgtgcccccaagctgtttcagtggc
ctgcattccctgaggcacctgtggctggatgacaatgcgttaacagaaatccccgtccag
gcttttagaagtttatcggcattgcaagccatgaccttggccctgaacaaaatacaccac
ataccagactatgcctttggaaacctctccagcttggtagttctacatctccataacaat
agaatccactccctgggaaagaaatgctttgatgggctccacagcctagagactttagat
ttaaattacaataaccttgatgaattccccactgcaattaggacactctccaaccttaaa
gaactaggatttcatagcaacaatatcaggtcgatacctgagaaagcatttgtaggcaac
ccttctcttattacaatacatttctatgacaatcccatccagtttgttgggagatctgct
tttcaacatttacctgaactaagaacactgactctgaatggtgcctcacaaataactgaa
tttcctgatttaactggaactgcaaacctggagagtctgactttaactggagcacagatc
tcatctcttcctcaaaccgtctgcaatcagttacctaatctccaagtgctagatctgtct
tacaacctattagaagatttacccagtttttcagtctgccaaaagcttcagaaaattgac
ctaagacataatgaaatctacgaaattaaagttgacactttccagcagttgcttagcctc
cgatcgctgaatttggcttggaacaaaattgctattattcaccccaatgcattttccact
ttgccatccctaataaagctggacctatcgtccaacctcctgtcgtcttttcctataact
gggttacatggtttaactcacttaaaattaacaggaaatcatgccttacagagcttgata
tcatctgaaaactttccagaactcaaggttatagaaatgccttatgcttaccagtgctgt
gcatttggagtgtgtgagaatgcctataagatttctaatcaatggaataaaggtgacaac
agcagtatggacgaccttcataagaaagatgctggaatgtttcaggctcaagatgaacgt
gaccttgaagatttcctgcttgactttgaggaagacctgaaagcccttcattcagtgcag
tgttcaccttccccaggccccttcaaaccctgtgaacacctgcttgatggctggctgatc
agaattggagtgtggaccatagcagttctggcacttacttgtaatgctttggtgacttca
acagttttcagatcccctctgtacatttcccccattaaactgttaattggggtcatcgca
gcagtgaacatgctcacgggagtctccagtgccgtgctggctggtgtggatgcgttcact
tttggcagctttgcacgacatggtgcctggtgggagaatggggttggttgccatgtcatt
ggttttttgtccatttttgcttcagaatcatctgttttcctgcttactctggcagccctg
gagcgtgggttctctgtgaaatattctgcaaaatttgaaacgaaagctccattttctagc
ctgaaagtaatcattttgctctgtgccctgctggccttgaccatggccgcagttcccctg
ctgggtggcagcaagtatggcgcctcccctctctgcctgcctttgccttttggggagccc
agcaccatgggctacatggtcgctctcatcttgctcaattccctttgcttcctcatgatg
accattgcctacaccaagctctactgcaatttggacaagggagacctggagaatatttgg
gactgctctatggtaaaacacattgccctgttgctcttcaccaactgcatcctaaactgc
cctgtggctttcttgtccttctcctctttaataaaccttacatttatcagtcctgaagta
attaagtttatccttctggtggtagtcccacttcctgcatgtctcaatccccttctctac
atcttgttcaatcctcactttaaggaggatctggtgagcctgagaaagcaaacctacgtc
tggacaagatcaaaacacccaagcttgatgtcaattaactctgatgatgtcgaaaaacag
tcctgtgactcaactcaagccttggtaacctttaccagctccagcatcacttatgacctg
cctcccagttccgtgccatcaccagcttatccagtgactgagagctgccatctttcctct
gtggcatttgtcccatgtctctaa
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