KEGG   Mus musculus (house mouse): 15496
Entry
15496             CDS       T01002                                 
Symbol
Hsd3b5
Name
(RefSeq) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00140  Steroid hormone biosynthesis
mmu01100  Metabolic pathways
mmu04913  Ovarian steroidogenesis
mmu04925  Aldosterone synthesis and secretion
mmu04927  Cortisol synthesis and secretion
mmu04934  Cushing syndrome
Module
mmu_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
mmu_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mmu_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
mmu_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    15496 (Hsd3b5)
   04925 Aldosterone synthesis and secretion
    15496 (Hsd3b5)
   04927 Cortisol synthesis and secretion
    15496 (Hsd3b5)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    15496 (Hsd3b5)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     15496 (Hsd3b5)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     15496 (Hsd3b5)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 NAD_binding_10 NmrA GDP_Man_Dehyd Polysacc_synt_2 KR RmlD_sub_bind Sacchrp_dh_NADP Semialdhyde_dh Ldh_1_N
Other DBs
NCBI-GeneID: 15496
NCBI-ProteinID: NP_032321
MGI: 104645
Ensembl: ENSMUSG00000038092
UniProt: Q61694
LinkDB
Position
3:complement(98525952..98552850)
AA seq 373 aa
MPGWSCLVTGAGGFLGQRIVRMLVQEEELQEIRALFRTFGRKHEEELSKLQTKAKVRVLK
GDILDAQCLKRACQGMSAVIHTAAAIDPLGAASRQTILDVNLKGTQLLLDACVEASVPTF
IYSSSVLVAGPNSYKEIILNAHEEEHRESTWPNPYPYSKRMAEKAVLATNGRLLKNGGTL
HTCALRLPFIYGEECQVTSTTVKTALKNNSIIKKNATFSIANPVYVGNAAWAHILAARSL
QDPKKSPSIQGQFYYISDNTPHQSYDDLNYTLSKEWGLCLDSGWSLPLSLLYWLAFLLET
VSFLLRPVYNYRPPFNRLLITVLNSVFTISYKKAQRDLGYQPLVSWEEAKQKTSEWIGTL
VKQHRETLHKKSQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgcctggatggagctgcctggtgacaggagcaggagggtttcttggccagaggattgtc
cgaatgttggtgcaggaggaagagttgcaggagatcagagccctgttcaggaccttcggt
cgaaaacatgaagaggaattgtccaagctgcagacaaaggccaaggtgagagtactgaag
ggagacattctggatgcccaatgcctgaagagagcctgccagggcatgtctgctgtcatc
cacaccgctgctgctattgacccccttggtgccgcttccagacagaccatcctagatgtc
aatctgaaaggtactcagctcctactggatgcttgtgtggaagccagtgtgccaacattc
atctacagcagctcagtgcttgtggctggaccaaattcctacaaggagatcatcctgaat
gcccatgaggaagagcatcgtgaaagcacatggcctaacccatacccatacagcaaaagg
atggctgagaaggcagtgctggcaacaaatgggagactcctgaaaaatggtggcactttg
catacttgtgccttaagactccctttcatctatggggaagaatgccaagtcacttcaacc
actgtgaaaacagcactgaagaacaacagcataattaagaaaaatgccacattctccatc
gccaacccagtgtatgtgggcaatgcagcctgggctcacattctggctgccaggagccta
caggaccccaagaagtccccaagcatccaaggacagttctattacatctctgataacacc
cctcaccaaagctatgatgatttaaattacaccctgagcaaggagtggggcctctgcctt
gattctggctggagccttcctctgtccctgctttactggcttgccttcctgctggaaact
gtgagcttcctgctacgtccagtttacaactataggccaccctttaaccgcctcttgatc
acagtgctaaatagcgtgtttaccatttcctataagaaagctcagcgcgatctaggctat
cagccacttgtcagctgggaggaagccaagcaaaaaacctcagagtggattggaacacta
gtgaagcagcacagggagacactacacaaaaagtcacagtga

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