AR045076A1 - Composicion de pelicula que se disuelve oralmente, pelicula multicomponente que se disuelve oralmente, uso de la composicion de pelicula y de la pelicula que se disuelve oralmente para preparar un medicamento, forma de dosificacion oral y procedimiento para preparar la composicion de pelicula que se - Google Patents

Composicion de pelicula que se disuelve oralmente, pelicula multicomponente que se disuelve oralmente, uso de la composicion de pelicula y de la pelicula que se disuelve oralmente para preparar un medicamento, forma de dosificacion oral y procedimiento para preparar la composicion de pelicula que se

Info

Publication number
AR045076A1
AR045076A1 ARP040102603A ARP040102603A AR045076A1 AR 045076 A1 AR045076 A1 AR 045076A1 AR P040102603 A ARP040102603 A AR P040102603A AR P040102603 A ARP040102603 A AR P040102603A AR 045076 A1 AR045076 A1 AR 045076A1
Authority
AR
Argentina
Prior art keywords
film
agent
composition
dissolves
orally
Prior art date
Application number
ARP040102603A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34102944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR045076(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AR045076A1 publication Critical patent/AR045076A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

Composición de película que se disuelve oralmente que comprende: a) un polímero entérico; b) al menos un agente tampón alcalino; y c) al menos un agente activo (11). Película multicomponente que se disuelve oralmente que comprende: a) un primer componente, que comprende un agente tampón alcalino y una carga soluble en agua; y b) un segundo componente, que comprende un agente activo de nicotina, un polímero entérico y un plastificante. Uso de la composición de película que se disuelve oralmente y de la película que se disuelve oralmente para preparar un medicamento de utilidad para proporcionar alivio rápido y sostenido de ansias de nicotina o para reducir o eliminar el consumo de tabaco en un individuo mediante la administración del medicamento. Forma de dosificación oral que comprende: a) al menos un agente activo de nicotina; b) al menos un material bioadhesivo capaz de formar un enlace de hidrógeno con el agente activo de nicotina; y c) al menos un agente de impacto sensorial que se libera rápidamente; en la que el agente de impacto sensorial de liberación rápida está presente en una cantidad eficaz para proporcionar alivio rápido del ansia de nicotina y en el que la forma de dosificación proporciona tanto alivio rápido como sostenido de ansia a un individuo en necesidad de la misma; y uso de al menos un agente activo de nicotina, al menos un componente bioadhesivo y al menos un agente de impacto sensorial de liberación rápida para preparar dicha forma de dosificación oral. Procedimiento para preparar una composición de película que se disuelve oralmente que comprende las etapas de: a) neutralizar un polímero entérico mezclándolo con un agente de neutralización alcalino en presencia de un disolvente para dar una mezcla polimérica; b) añadir además un agente activo a la mezcla polimérica; c) vaciar la mezcla polimérica en una superficie adecuada; y d) secar dicha mezcla polimérica para dar una película polimérica. El procedimiento puede comprender además las etapas de: e) disolver un agente tampón alcalino y una carga soluble en agua para dar una mezcla tampón; f) vaciar la mezcla tampón en la película polimérica para dar una película polimérica revestida; y g) secar dicha película polimérica revestida.
ARP040102603A 2003-07-24 2004-07-22 Composicion de pelicula que se disuelve oralmente, pelicula multicomponente que se disuelve oralmente, uso de la composicion de pelicula y de la pelicula que se disuelve oralmente para preparar un medicamento, forma de dosificacion oral y procedimiento para preparar la composicion de pelicula que se AR045076A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48985503P 2003-07-24 2003-07-24

Publications (1)

Publication Number Publication Date
AR045076A1 true AR045076A1 (es) 2005-10-12

Family

ID=34102944

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040102603A AR045076A1 (es) 2003-07-24 2004-07-22 Composicion de pelicula que se disuelve oralmente, pelicula multicomponente que se disuelve oralmente, uso de la composicion de pelicula y de la pelicula que se disuelve oralmente para preparar un medicamento, forma de dosificacion oral y procedimiento para preparar la composicion de pelicula que se

Country Status (24)

Country Link
US (1) US9675548B2 (es)
EP (2) EP2446881B1 (es)
JP (4) JP2006528636A (es)
CN (1) CN100508976C (es)
AR (1) AR045076A1 (es)
AU (2) AU2004259006B2 (es)
BR (1) BRPI0412752B8 (es)
CA (1) CA2533577C (es)
CL (2) CL2008002406A1 (es)
DK (2) DK1648421T3 (es)
ES (2) ES2654062T3 (es)
HK (1) HK1169802A1 (es)
HR (1) HRP20171944T1 (es)
HU (1) HUE037508T2 (es)
LT (1) LT1648421T (es)
MX (1) MXPA06000852A (es)
PE (1) PE20050496A1 (es)
PL (2) PL1648421T3 (es)
PT (2) PT1648421T (es)
RU (2) RU2351315C2 (es)
SI (1) SI1648421T1 (es)
TW (1) TW200514579A (es)
UY (1) UY28431A1 (es)
WO (1) WO2005009386A2 (es)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1691631A4 (en) 2003-11-07 2012-09-05 Us Smokeless Tobacco Co TOBACCO COMPOSITIONS
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
DE102005033943A1 (de) * 2005-07-20 2007-02-22 Hexal Ag Nicht-ausspuckbarer, oraler, schnell-zerfallender Film für ein Neuroleptikum
DE102005058569B4 (de) * 2005-12-08 2010-07-15 Lts Lohmann Therapie-Systeme Ag Schaumwafer mit Polyvinylalkohol-Polyethylenglycol-Pfropfcopolymer
US7810507B2 (en) 2006-02-10 2010-10-12 R. J. Reynolds Tobacco Company Smokeless tobacco composition
CN101384249B (zh) * 2006-02-17 2011-11-30 诺瓦提斯公司 可崩解口腔膜剂
US20100015068A1 (en) * 2006-07-06 2010-01-21 Massachusetts Institute Of Technology Methods and Compositions For Altering Biological Surfaces
WO2008080773A1 (de) * 2006-12-29 2008-07-10 Basf Se Verfahren zur herstellung von festen dosierungsformen enthaltend pfropfcopolymere
FR2912915B1 (fr) * 2007-02-28 2012-11-16 Pf Medicament Film a desintegration rapide pour l'administration buccale de substances actives.
CN101621990B (zh) * 2007-03-07 2012-11-21 诺瓦提斯公司 可口服施用的膜剂
JP5167345B2 (ja) * 2007-05-07 2013-03-21 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング 薬剤を加速放出する腸溶コーティングを含む固体剤形
EP2179666B1 (en) 2007-07-23 2012-08-29 R.J.Reynolds Tobacco Company Smokeless Tobacco Compositions And Methods For Treating Tobacco For Use Therein
WO2009043588A2 (en) * 2007-10-02 2009-04-09 LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH Ph regulating antibacterial films for the oral or vaginal cavity
EP2217102B1 (en) * 2007-10-11 2023-04-05 Philip Morris Products S.A. Smokeless tobacco product
US9125434B2 (en) * 2007-10-11 2015-09-08 Philip Morris Products S.A. Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet
JP2009102287A (ja) * 2007-10-19 2009-05-14 Seiji Sakao 禁煙用の辛い唐辛子
US20090253754A1 (en) * 2007-12-04 2009-10-08 Francesca Selmin Fast dissolving films and coatings for controlled release of flavors, active pharmaceutical ingredients, food substances, and nicotine
AU2008334684A1 (en) * 2007-12-11 2009-06-18 Novartis Ag Multi-zone films
WO2009080022A1 (en) * 2007-12-20 2009-07-02 Fertin Pharma A/S Compressed chewing gum tablet
DK2229157T3 (en) * 2007-12-20 2016-12-05 Fertin Pharma As Compressed chewing gum tablet
BRPI0906648A2 (pt) * 2008-01-31 2019-11-19 Mcneil Ppc Inc tiras de filme comestível para liberação imediata de ingredientes ativos
CN102014883A (zh) * 2008-01-31 2011-04-13 麦克内尔-Ppc股份有限公司 具有调释型活性成分的可食用膜条片
WO2009100871A2 (en) * 2008-02-13 2009-08-20 Bayer Schering Pharma Aktiengesellschaft Drug delivery system with stabilising effect
WO2009128433A1 (ja) * 2008-04-15 2009-10-22 塩野義製薬株式会社 フィルム状組成物
WO2010054826A1 (en) * 2008-11-13 2010-05-20 Giuliani International Limited Antisense compositions and methods of making and using same
EP2210595A1 (en) * 2009-01-14 2010-07-28 LEK Pharmaceuticals d.d. Active coating of pharmaceutical dosage forms
US20100256197A1 (en) * 2009-04-02 2010-10-07 Silver Eagle Labs Nv, Llc Nicotine Dissolving Film With Or Without Menthol
US20100256215A1 (en) * 2009-04-02 2010-10-07 Silver Eagle Labs Nv, Llc Menthol-Melatonin Dissolving Film
CA2759985A1 (en) 2009-05-12 2010-11-18 Bpsi Holdings, Llc Enhanced moisture barrier immediate release film coating systems and substrates coated therewith
CN102427782A (zh) * 2009-05-21 2012-04-25 比奥内克斯制药有限公司 双层和单层剂型
US8434496B2 (en) 2009-06-02 2013-05-07 R. J. Reynolds Tobacco Company Thermal treatment process for tobacco materials
US8944072B2 (en) 2009-06-02 2015-02-03 R.J. Reynolds Tobacco Company Thermal treatment process for tobacco materials
JP5760295B2 (ja) * 2009-06-12 2015-08-05 シナプサス セラピューティクス，インコーポレーテッド 舌下用アポモルフィン
WO2010146601A1 (en) * 2009-06-15 2010-12-23 Unijules Life Sciences Ltd Rapid dissolvable oral film for delivering herbal extract/s with or without other pharmaceutically active agents
US20110139164A1 (en) * 2009-12-15 2011-06-16 R. J. Reynolds Tobacco Company Tobacco Product And Method For Manufacture
US20110220130A1 (en) * 2009-12-15 2011-09-15 John-Paul Mua Tobacco Product And Method For Manufacture
US8955523B2 (en) 2010-01-15 2015-02-17 R.J. Reynolds Tobacco Company Tobacco-derived components and materials
US20130014771A1 (en) 2011-01-13 2013-01-17 R. J. Reynolds Tobacco Company Tobacco-derived components and materials
US8397945B2 (en) 2010-02-23 2013-03-19 R.J. Reynolds Tobacco Company Dispensing container
BR112012024092A2 (pt) * 2010-03-23 2016-09-06 Bioalliance Pharma filme de rápida dissolução oral
US9039839B2 (en) 2010-04-08 2015-05-26 R.J. Reynolds Tobacco Company Smokeless tobacco composition comprising tobacco-derived material and non-tobacco plant material
EP2557947A1 (en) 2010-04-14 2013-02-20 Altria Client Services Inc. Preformed smokeless tobacco product
US9402415B2 (en) 2010-04-21 2016-08-02 R. J. Reynolds Tobacco Company Tobacco seed-derived components and materials
CN102858327A (zh) * 2010-04-27 2013-01-02 诺瓦提斯公司 口腔剂型
US20110268809A1 (en) 2010-04-28 2011-11-03 Paul Andrew Brinkley Nicotine-Containing Pharmaceutical Compositions
US20110274628A1 (en) 2010-05-07 2011-11-10 Borschke August J Nicotine-containing pharmaceutical compositions
US9675102B2 (en) 2010-09-07 2017-06-13 R. J. Reynolds Tobacco Company Smokeless tobacco product comprising effervescent composition
DE102010048408A1 (de) 2010-10-15 2012-04-19 Lts Lohmann Therapie-Systeme Ag Laminat mit verbessertem Wasserretentionsverhalten
US20120125354A1 (en) 2010-11-18 2012-05-24 R.J. Reynolds Tobacco Company Fire-Cured Tobacco Extract and Tobacco Products Made Therefrom
KR102025238B1 (ko) * 2010-12-16 2019-09-25 선오비온 파마슈티컬스 인코포레이티드 설하 필름
US20120152265A1 (en) 2010-12-17 2012-06-21 R.J. Reynolds Tobacco Company Tobacco-Derived Syrup Composition
US9107453B2 (en) 2011-01-28 2015-08-18 R.J. Reynolds Tobacco Company Tobacco-derived casing composition
US8893725B2 (en) 2011-01-28 2014-11-25 R. J. Reynolds Tobacco Company Polymeric materials derived from tobacco
US9254001B2 (en) 2011-04-27 2016-02-09 R.J. Reynolds Tobacco Company Tobacco-derived components and materials
US9192193B2 (en) 2011-05-19 2015-11-24 R.J. Reynolds Tobacco Company Molecularly imprinted polymers for treating tobacco material and filtering smoke from smoking articles
US20130078307A1 (en) 2011-09-22 2013-03-28 Niconovum Usa, Inc. Nicotine-containing pharmaceutical composition
EP3108876A1 (en) * 2011-10-13 2016-12-28 Jaleva Pharmaceuticals LLC Methods and compositions for rapid transbuccal delivery of active agents
US9907748B2 (en) 2011-10-21 2018-03-06 Niconovum Usa, Inc. Excipients for nicotine-containing therapeutic compositions
US20130125907A1 (en) 2011-11-17 2013-05-23 Michael Francis Dube Method for Producing Triethyl Citrate from Tobacco
US10881132B2 (en) 2011-12-14 2021-01-05 R.J. Reynolds Tobacco Company Smokeless tobacco product comprising effervescent composition
US9763928B2 (en) 2012-02-10 2017-09-19 Niconovum Usa, Inc. Multi-layer nicotine-containing pharmaceutical composition
CN104284605B (zh) 2012-03-19 2018-02-23 R.J.雷诺兹烟草公司 用于处理提取的烟草浆的方法和由此制备的烟草产品
US10799451B2 (en) * 2012-03-27 2020-10-13 Nicoccino Ab Nicotine formulation
WO2014018075A1 (en) 2012-07-23 2014-01-30 Crayola, Llc Dissolvable films and methods of using the same
US20150250887A1 (en) * 2012-10-12 2015-09-10 Jaleva Pharmaceuticals, Llc Method of preparing resin tinctures
EP2925273A4 (en) 2012-11-28 2016-08-31 Jaleva Pharmaceuticals Llc DOPPELKAMMERAPPLIKATOR
US20140166028A1 (en) * 2012-12-14 2014-06-19 Richard C. Fuisz Enhanced Delivery of Nicotine, THC, Tobacco, Cannabidiol or Base Alkaloid from an Electronic Cigarette or Other Vapor or Smoke Producing Device Through Use of an Absorption Conditioning Unit
US20140166027A1 (en) * 2012-12-14 2014-06-19 Richard C. Fuisz Enhanced Delivery of Nicotine, THC, Tobacco, Cannabidiol or Base Alkaloid from an Electronic Cigarette or Other Vapor Producing Device Through Use of an Absorption Conditioning Unit
US9289011B2 (en) 2013-03-07 2016-03-22 R.J. Reynolds Tobacco Company Method for producing lutein from tobacco
WO2014159673A2 (en) * 2013-03-14 2014-10-02 Altria Client Services Inc. Soft oral product
US10799548B2 (en) * 2013-03-15 2020-10-13 Altria Client Services Llc Modifying taste and sensory irritation of smokeless tobacco and non-tobacco products
US20140275148A1 (en) * 2013-03-15 2014-09-18 Novus Pharma LLC Orally administrable, self-supporting dissolving film dosage forms
WO2014188079A1 (en) * 2013-05-23 2014-11-27 Åbo Akademi University Printed dosage forms
US20150034109A1 (en) 2013-08-02 2015-02-05 R.J. Reynolds Tobacco Company Process for Producing Lignin from Tobacco
US11503853B2 (en) 2013-09-09 2022-11-22 R.J. Reynolds Tobacco Company Smokeless tobacco composition incorporating a botanical material
US20160220472A1 (en) * 2013-09-11 2016-08-04 3M Innovative Properties Company Oral compositions
US10357054B2 (en) 2013-10-16 2019-07-23 R.J. Reynolds Tobacco Company Smokeless tobacco pastille
US20150147555A1 (en) * 2013-11-23 2015-05-28 Orahealth Corporation Multilayer mucoadhering patch with a nonadhering layer comprising casein
CA2931547A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
CN105873737A (zh) 2013-12-31 2016-08-17 强生消费者公司 形成多层成型膜产品的单程方法
US20150182992A1 (en) 2013-12-31 2015-07-02 Johnson & Johnson Consumer Companies, Inc. Process for forming a multilayered shaped film product
ES2977380T3 (es) 2013-12-31 2024-08-22 Johnson & Johnson Consumer Inc Proceso para formar un producto de película conformado
US9265284B2 (en) 2014-01-17 2016-02-23 R.J. Reynolds Tobacco Company Process for producing flavorants and related materials
AU2015360580A1 (en) * 2014-12-09 2017-06-15 Aquestive Therapeutics, Inc. Linear polysaccharide based film products
DE102015201871B4 (de) * 2015-02-03 2018-04-05 Ferton Holding S.A. Verwendung eines Pulvers als Mittel zur Pulverstrahlbearbeitung in einem Pulverstrahlgerät und Verfahren zur Reinigung von Zähnen
US10881133B2 (en) 2015-04-16 2021-01-05 R.J. Reynolds Tobacco Company Tobacco-derived cellulosic sugar
WO2016172095A1 (en) 2015-04-21 2016-10-27 Cynapsus Therapeutics, Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
US20170059554A1 (en) 2015-09-02 2017-03-02 R. J. Reynolds Tobacco Company Method for monitoring use of a tobacco product
ITUB20153446A1 (it) * 2015-09-07 2017-03-07 Pharmafilm Srl Film orodispersibili a rapida disgregazione per uso terapeutico o alimentare
US10869497B2 (en) 2015-09-08 2020-12-22 R.J. Reynolds Tobacco Company High-pressure cold pasteurization of tobacco material
US10532046B2 (en) 2015-12-03 2020-01-14 Niconovum Usa, Inc. Multi-phase delivery compositions and products incorporating such compositions
US20170165252A1 (en) 2015-12-10 2017-06-15 Niconovum Usa Inc. Protein-enriched therapeutic composition
US10499684B2 (en) 2016-01-28 2019-12-10 R.J. Reynolds Tobacco Company Tobacco-derived flavorants
US11154087B2 (en) 2016-02-02 2021-10-26 R.J. Reynolds Tobacco Company Method for preparing flavorful compounds isolated from black liquor and products incorporating the flavorful compounds
CN109475508A (zh) * 2016-06-07 2019-03-15 阿瑞迪思医药品股份有限责任公司 具有增强的热稳定性的含有生物活性材料的速溶薄膜的制备方法
IL247161A0 (en) * 2016-08-08 2016-12-29 Rubin Yoram Fast-dissolving adhesive films for the treatment of oral conditions
US11091446B2 (en) 2017-03-24 2021-08-17 R.J. Reynolds Tobacco Company Methods of selectively forming substituted pyrazines
WO2018205017A1 (en) * 2017-05-08 2018-11-15 Intelgenx Corp. Film dosage form with extended release mucoadhesive particles
CA3085065C (en) 2017-12-08 2023-12-05 Fertin Pharma A/S Formulations providing high nicotine concentrations
PL3720418T3 (pl) 2017-12-08 2021-12-20 Fertin Pharma A/S Tabletka nikotynowa
US20190307082A1 (en) 2018-04-05 2019-10-10 R.J. Reynolds Tobacco Company Oriental tobacco production methods
WO2019204708A1 (en) * 2018-04-21 2019-10-24 Quest Products, Llc Bilayer adhering lozenge effective to mask undesirable flavor
DK3807260T3 (da) 2018-06-15 2024-10-14 Reynolds Tobacco Co R Oprensning af nikotin
WO2019244176A1 (en) * 2018-06-23 2019-12-26 Strides Shasun Limited Stable nicotine lozenges
US11235013B2 (en) 2018-09-04 2022-02-01 Babak Ghalili Cannabinoid, menthol and caffeine dissolvable film compositions, devices and methods
JP7361547B2 (ja) 2019-09-10 2023-10-16 三菱電機ビルソリューションズ株式会社 ロボットシステム
WO2021177941A1 (en) * 2020-03-03 2021-09-10 Babak Ghalili Cannabinoid, menthol and caffeine dissolvable film compositions, devices and methods
WO2022224196A1 (en) * 2021-04-22 2022-10-27 Nicoventures Trading Limited Orally dissolving films
WO2024201504A1 (en) * 2023-03-25 2024-10-03 Sri Ramachandra Institute Of Higher Education & Research A process of preparation of fast dispersing film containing ascorbic acid and product thereof
WO2024037043A1 (zh) * 2023-04-28 2024-02-22 深圳华宝协同创新技术研究院有限公司 用于口腔粘膜的包含尼古丁的薄膜组合物
CN116570027A (zh) * 2023-06-15 2023-08-11 东莞市吉纯生物技术有限公司 一种含有辣椒素提取物的口含制品及其制备方法

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288498A (en) 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
JPH0729915B2 (ja) 1986-02-01 1995-04-05 帝國製薬株式会社 シ−ト状口腔内貼付剤
JPS62223112A (ja) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk 歯周病治療剤
DE3827561C1 (es) * 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE4310012A1 (de) 1993-03-27 1994-09-29 Roehm Gmbh Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung
WO1995001766A1 (en) 1993-07-09 1995-01-19 Cygnus Therapeutic Systems Method and device for providing nicotine replacement therapy transdermally/transbuccally
GB9405137D0 (en) 1994-03-16 1994-04-27 Xaar Ltd Improvements relating to pulsed droplet deposition apparatus
WO1996000072A1 (en) 1994-06-23 1996-01-04 The Procter & Gamble Company Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine
US5508276A (en) * 1994-07-18 1996-04-16 Eli Lilly And Company Duloxetine enteric pellets
AU4657896A (en) 1995-01-19 1996-08-07 Cygnus, Inc. Polyisobutylene adhesives containing high TG tackifier for transdermal devices
JPH08245423A (ja) 1995-03-06 1996-09-24 Shionogi & Co Ltd 水系腸溶性コーティング液
EP0906089B1 (en) * 1996-05-13 2003-08-27 Novartis Consumer Health S.A. Buccal delivery system
DE19626045C2 (de) * 1996-06-28 1998-12-03 Klinge Co Chem Pharm Fab Stabile Arzneiform zur oralen Verabreichung, welche Omeprazol als aktiven Wirkstoff enthält, sowie Verfahren zur Herstellung derselben
US6623759B2 (en) 1996-06-28 2003-09-23 Astrazeneca Ab Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof
GB9614902D0 (en) 1996-07-16 1996-09-04 Rhodes John Sustained release composition
DE19646392A1 (de) 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
DE19653605C2 (de) 1996-12-20 2002-11-28 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems
USRE38524E1 (en) * 1997-06-25 2004-06-01 Pfizer Inc. Dipeptide derivatives as growth hormone secretagogues
US6197331B1 (en) * 1997-07-24 2001-03-06 Perio Products Ltd. Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity
US20030176467A1 (en) 1997-09-25 2003-09-18 Sven Andersson Nicotine compositions
JP3460538B2 (ja) 1997-10-08 2003-10-27 救急薬品工業株式会社 速溶性フィルム製剤
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
EP0965592A1 (en) 1998-06-18 1999-12-22 F. Hoffmann-La Roche Ag Process for preparing 3-arylsulfur hydroxamic acids
US6358060B2 (en) 1998-09-03 2002-03-19 Jsr Llc Two-stage transmucosal medicine delivery system for symptom relief
US6596298B2 (en) 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
US20030170195A1 (en) 2000-01-10 2003-09-11 Noven Pharmaceuticals, Inc. Compositions and methods for drug delivery
PT1061900E (pt) 1999-01-14 2005-04-29 Noven Pharma Composicoes e metodos para libertacao de uma droga
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
US6248760B1 (en) 1999-04-14 2001-06-19 Paul C Wilhelmsen Tablet giving rapid release of nicotine for transmucosal administration
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US6420473B1 (en) 2000-02-10 2002-07-16 Bpsi Holdings, Inc. Acrylic enteric coating compositions
US7067116B1 (en) 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
KR100452972B1 (ko) 2000-05-16 2004-10-14 주식회사 삼양사 경피투여용 하이드로젤 조성물
JP4555436B2 (ja) 2000-06-29 2010-09-29 富士通株式会社 薄膜樹脂基板への樹脂モールド方法及び高周波モジュール
DE10032456A1 (de) 2000-07-04 2002-01-31 Lohmann Therapie Syst Lts Schnell zerfallende Darreichungsform zur Freisetzung von Wirkstoffen im Mundraum oder in Körperhöhlen
US8566211B2 (en) 2000-11-22 2013-10-22 Efficient Auctions, Llc System and method for a dynamic auction with package bidding
US20020131990A1 (en) 2000-11-30 2002-09-19 Barkalow David G. Pullulan free edible film compositions and methods of making the same
US6479076B2 (en) 2001-01-12 2002-11-12 Izhak Blank Nicotine delivery compositions
DE10110391A1 (de) 2001-03-03 2002-09-26 Lohmann Therapie Syst Lts Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff
CN1553771A (zh) * 2001-03-26 2004-12-08 史密丝克莱恩比彻姆公司 含烟碱的口服剂量形式
CA2449415A1 (en) 2001-04-20 2002-10-31 Lavipharm Laboratories Inc. Intraoral delivery of nicotine for smoking cessation
EA200301250A1 (ru) * 2001-06-22 2004-06-24 Пфайзер Продактс Инк. Фармацевтические композиции, содержащие слаборастворимые и/или чувствительные к кислотам лекарственные средства и нейтрализованные кислотные полимеры
WO2003003957A1 (en) 2001-07-06 2003-01-16 Lavipharm Laboratories Inc. Quick dissolving oral mucosal drug delivery device with moisture barrier coating
DE10141652B4 (de) 2001-08-24 2011-04-07 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung
US20030092724A1 (en) 2001-09-18 2003-05-15 Huaihung Kao Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic
JP5089840B2 (ja) 2001-09-25 2012-12-05 救急薬品工業株式会社 ニコチン含有フィルム製剤
MXPA04002891A (es) * 2001-09-28 2005-06-20 Johnson & Johnson Composicion farmaceutica a base de pasta de azucar.
US7425292B2 (en) * 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20040037879A1 (en) * 2001-11-02 2004-02-26 Adusumilli Prasad S. Oral controlled release forms useful for reducing or preventing nicotine cravings
US20030099691A1 (en) 2001-11-16 2003-05-29 Susan Lydzinski Films containing starch
JP2003213038A (ja) 2001-11-16 2003-07-30 Natl Starch & Chem Investment Holding Corp デンプンを含有するフィルム
DE10224612A1 (de) * 2002-06-04 2003-12-24 Lohmann Therapie Syst Lts Wirkstoffhaltige filmförmige Zubereitungen mit verbesserter chemischer Stabilität, und Verfahren zu deren Herstellung
US20040013752A1 (en) 2002-07-05 2004-01-22 Wolfson Philip E. Buccal and sublingual mucosally absorbed herbal compositions for relieving nicotine withdrawal symptoms and craving for nicotine and nicotine containing substances
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
US8216609B2 (en) 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
US20030049307A1 (en) 2002-08-15 2003-03-13 Gyurik Robert J. Pharmaceutical composition
DE10256775A1 (de) 2002-12-05 2004-06-24 Lts Lohmann Therapie-Systeme Ag Filmförmige Zubereitungen zur transmucosalen Verabreichung von Nicotin, sowie Verfahren zu deren Herstellung
ES2968706T3 (es) 2002-12-20 2024-05-13 Niconovum Ab Una combinación de nicotina y celulosa
US20040208931A1 (en) 2002-12-30 2004-10-21 Friend David R Fast dissolving films for oral administration of drugs
EP1648362A4 (en) 2003-07-01 2012-01-11 Todd Maibach FILM CONTAINING THERAPEUTIC AGENTS
DE10338544B4 (de) 2003-08-19 2017-08-31 Janssen Pharmaceutica N.V. Buccale Formulierungen des Galanthamins und deren Anwendungen
KR20050048056A (ko) 2003-11-18 2005-05-24 (주)케이비피 경구용 소모 필름 조성물
DE10354894A1 (de) 2003-11-24 2005-07-07 Hf Arzneimittelforschung Gmbh Orale Formulierungen des Desoxypeganins und deren Anwendungen
US20050181050A1 (en) 2004-01-28 2005-08-18 Collegium Pharmaceutical, Inc. Dosage forms using drug-loaded ion exchange resins
US20050255048A1 (en) 2004-05-15 2005-11-17 Collegium Pharmaceutical, Inc. Sprayable formulations for the treatment of acute inflammatory skin conditions
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
WO2006025882A2 (en) 2004-08-25 2006-03-09 The Uab Research Foundation Absorption enhancers for drug administration
US20060046969A1 (en) 2004-08-25 2006-03-02 Aegis Therapeutics Llc Antibacterial compositions for drug administration
US20060046962A1 (en) 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
TW200628175A (en) 2004-10-08 2006-08-16 Noven Pharma Transdermal drug delivert device including an occlusive backing
MX2007004495A (es) 2004-10-15 2007-05-10 Pfizer Prod Inc Composiciones y procedimientos para la administracion intranasal, bucal, sublingual y pulmonar de vareniclina.
GB0508306D0 (en) 2005-04-25 2005-06-01 Bioprogress Technology Ltd Nicotine dosage forms
JP5000932B2 (ja) 2005-06-21 2012-08-15 日東電工株式会社 ニコチン含有経皮吸収製剤
CN101384249B (zh) 2006-02-17 2011-11-30 诺瓦提斯公司 可崩解口腔膜剂
US20070269386A1 (en) 2006-05-16 2007-11-22 Per Steen New product and use and manufacture thereof
US20100028447A1 (en) 2007-01-22 2010-02-04 Targacept, Inc. Intranasal, Buccal, And Sublingual Administration Of Metanicotine Analogs
FR2912915B1 (fr) 2007-02-28 2012-11-16 Pf Medicament Film a desintegration rapide pour l'administration buccale de substances actives.
CN101621990B (zh) 2007-03-07 2012-11-21 诺瓦提斯公司 可口服施用的膜剂
US20080286340A1 (en) 2007-05-16 2008-11-20 Sven-Borje Andersson Buffered nicotine containing products
US20080292683A1 (en) 2007-05-24 2008-11-27 Monosolrx, Llc. Film shreds and delivery system incorporating same
KR101405930B1 (ko) * 2007-07-05 2014-06-12 엘지전자 주식회사 식기 세척기의 제어방법
US20090081294A1 (en) 2007-09-26 2009-03-26 Gin Jerry B Sustained release dosage form for lubricating an oral cavity
KR100905027B1 (ko) 2007-10-03 2009-06-30 (주)씨엘팜 식용 필름
WO2009045022A2 (en) 2007-10-03 2009-04-09 C.L. Pharm Edible film
US20090253754A1 (en) 2007-12-04 2009-10-08 Francesca Selmin Fast dissolving films and coatings for controlled release of flavors, active pharmaceutical ingredients, food substances, and nicotine
AU2008334684A1 (en) 2007-12-11 2009-06-18 Novartis Ag Multi-zone films
PT2361081T (pt) 2008-10-14 2016-09-05 Mcneil Ab Forma de dosagem intra-oral multiporção e seu uso
US20100247586A1 (en) 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
KR101074271B1 (ko) 2009-06-25 2011-10-17 (주)차바이오앤디오스텍 불쾌한 맛을 효과적으로 은폐한 경구용 속용 필름
US20130011462A1 (en) 2009-12-30 2013-01-10 Novartis Ag Melt extruded nicotine thin strips
CN102858327A (zh) 2010-04-27 2013-01-02 诺瓦提斯公司 口腔剂型
CA2811962A1 (en) 2010-09-24 2012-03-29 Nexmed Holdings, Inc. Enhanced transbuccal drug delivery system and compositions

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